INFLUENCE OF HISTAMINE AND RELATED COMPOUNDS ON THE HYPNOTIC EFFECT OF THIOPENTAL IN MICE
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概要
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Intraventricular injection of histamine (Hi) significantly prolonged thiopental sleeping time at doses of 0.5μg or larger. Both 1-methylHi and imidazole-4-acetic acid, howere, did not affect thiopental narcosis. Pretreatment with α-fluoromethylhistidine diminished the effect of Hi, while histidine, metoprine and quinacrine prolonged thiopental narcosis. Injection with 2-methylHi did not affect thiopental sleeping time, while as in the case of Hi, 4-methylHi augmented the thiopental effect. In addition, H_2-receptor blocking agents such as cimetidine, ranitidine and famotidine clearly antagonized Hi-induced prolongation of thiopental narcosis, while pyrilamine and chlorpheniramine had no effect. These results indicate that Hi-induced prolongation of thiopental narcosis appears to be exerted via H_2 receptors and is, in some way, related to the Hi content in the brain.
- 公益社団法人日本薬学会の論文
著者
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Akahori Hiromichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Tasaka Kenji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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