Effects of Cholinergic Drugs and Cerebral Metabolic Activators on Memory Impairment in Old Rats
スポンサーリンク
概要
- 論文の詳細を見る
Age-related changes in the acquisition and retention of memory based on the step-through active avoidance response were studied in rats and the effects of cholinergic drugs and cerebral metabolic activators on memory impairment in old rats were also tested. Six-and 12-month-old rats showed lower rates of acquisition of the active avoidance response than did 2-month-old rats. In addition, the retention of the active avoidance response in 6-and 12-month-old rats diminished rather rapidly compared with that observed in 2-month-old rats. Intraventricular injection of acetylcholine at doses of 20 and 50 ng caused a significant improvement of memory impairment in old rats. Physostigmine and arecoline also caused a significant ameliorating effect at doses of 0.02 and 0.05 mg/kg i.p. and 0.2 and 0.5 mg/kg i.p., respectively. Hopantenate calcium (100 mg/kg, p.o.), idebenone (20 and 50 mg/kg, i.p.), indeloxazine (50 mg/kg, p.o.) and DM-9384 (30 mg/kg, p.o.) also proved useful to improve memory impairment in old rats.
- 公益社団法人日本薬学会の論文
著者
-
Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
Tasaka K
Okayama Univ. Okayama Jpn
-
Tasaka Kenji
Production Engineering Research Laboratory Hitachi Ltd.
-
Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
-
Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
-
Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
-
TSUJIMOTO Susumu
Department of Pharmacology, Pharmacological Research Laboratories, Fujisawa Pharmaceutical Co.,Ltd.
-
Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
-
TASAKA Kenji
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University Okayama
-
Tasaka Kenji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
-
Tsujimoto Susumu
Department Of Pharmacology Pharmacological Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Tsujimoto Susumu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
関連論文
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate–Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats
- Participation of Prostaglandin E2 Receptor in Nasal Congestion of Brown Norway Rats
- Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task(Pharmacology)
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- Interaction between Hippocampal γ-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats
- Anticonvulsant Effect of (RS)-1-Aminoindan-1,5-dicarboxylic Acid on Pentetrazol-Induced Kindled Seizures in Mice
- Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
- Effects of Peppermint (Mentha piperita L.) Extracts on Experimental Allergic Rhinitis in Rats
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- Participation of GABAergic and Histaminergic Systems in Inhibiting Amygdaloid Kindled Seizures
- Slow Wave Sleep-inducing Effects of First Generation H_1-Antagonists
- Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia
- Preparation and Characterization of Two Crystalline Forms of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159)
- Synthesis and Pharmacological Activity of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159) and Its Optical Isomers
- Development of Amygdaloid Kindling in Histidine Decarboxylase-deficient and Histamine H_1 Receptor-deficient Mice
- Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust(Pharmacology)
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice
- Anti-cachectic Effect of FK317, a Novel Anti-cancer Agent, in Colon26 and LX-1 Models in Mice
- FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice
- Different Effects of FK317 on Multidrug-resistant Tumor in vivo and in vitro
- Cytotoxic Mechanisms of FK317, a New Class of Bioreductive Agent with Potent Antitumor Activity
- A New Aromatase Inhibitor, FR901537 II.Pharmacological and Antitumor Effects
- Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
- Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate-Receptor Blockade
- Influences of Histamine H_1 Receptor Antagonists on Maximal Electroshock Seizure in Infant Rats(Pharmacology)
- Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats(Pharmacology)
- Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice
- Characteristic Effects of Anti-dementia Drugs on Rat Sleep Patterns
- Participation of Histamine H_3 Receptors in Experimental Allergic Rhinitis of Mice
- The Effects of Selective Serotonin-Reuptake Inhibitor on Visual Evoked Potential in Rats
- Comparative Study of Certain Antibiotics on Epileptogenic Property, Including (1Rpi, 5S, 6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a] [1,2,4] triazolium-6-yl)] thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate (LJC10627), a Carbapenem Antibiotic wit
- Effects of a New Non : Steroidal 5α : Reductase Inhibitor, FK143, on the Prostate Gland in Beagle Dogs
- Mechanism of the Inhibitory Effect of Histamine on Amygdaloid-Kindled Seizures in Rats
- Effects of Fujibitol, a Remedy for Nasal Symptoms, on Experimental Allergic Rhinitis in Rats
- Characterization of ASK Mice, a Strain Highly Sensitive to Anaphylactic Shock
- Role of Substance P on Histamine H_3 Antagonist-Induced Scratching Behavior in Mice
- Caffeic Acid Inhibits Compound 48/80-Induced Allergic Symptoms in Mice(Pharmacology)
- Structural Study of Ultrathin Hydrogenated Amorphous Carbon Films Using Spectroscopic Ellipsometry and Ultraviolet Raman Spectroscopy
- Control of Plasma Parameters for High-Quality Hydrogenated Amorphous Carbon Growth
- Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats(Pharmacology)
- Influences of Everninomicin, Vancomycin and Teicoplanin on Chemical Mediator Release From Rat Peritoneal Mast Cells
- Increasing Effect by Simultaneous Use of Levocabastine and Pemirolast on Experimental Allergic Conjunctivitis in Rats(Pharmacology)
- DIFFERENTIAL ANTAGONISM OF ANTIAVOIDANCE, CATALEPTIC AND PTOTIC EFFECTS OF NEUROLEPTICS BY BIPERIDEN
- EFFECT OF NEUROLEPTIC DRUGS ON THE CONDITIONED BEHAVIOR AFTER PRETREATMENT WITH α-METHYLTYROSINE OR p-CHLOROPHENYLALANINE
- Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen
- Effects of Histidine on Working Memory Deficits Induced by the 5-HT_-Receptor Agonist 8-OH-DPAT
- Effect of Propolis Extract on D-Galactosamine-Induced Hepatic Injury in Rats
- Mechanism of Bradykinin-Induced Histamine Release from Rat Peritoneal Mast Cells
- Effects of Anti-dementia Drugs on Morphine-Induced Somnolence
- ANTI-INFLAMMATORY POLYSACCHARIDE PRODUCED BY SERRATIA PISCATORUM
- Effects of Hop Extracts on Nasal Rubbing and Sneezing in BALB/c Mice(Pharmacology)
- Effects of Antiepileptics on Lateral Geniculate Nucleus-Kindled Seizures in Rats
- Effects of a Dictamnus dasycarpus T. Extract on Allergic Models in Mice
- Effects of Various Antiepileptics on Behavioral and Electroencephalographic Seizures Induced by Maximal Electroshock in Mice
- Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions(Pharmacology)
- Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice(Pharmacology)
- Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in Mice
- Characteristics of Scratching Behavior Induced by Some Chemical Mediators in Hairless Mice
- Antipruritic and Antierythema Effects of Ascomycete Bulgaria inquinans Extract in ICR Mice(Pharmacology)
- Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on Nasal Rubbing and Scratching Behavior in ICR Mice(Pharmacology)
- Effects of Cholinergic Drugs and Cerebral Metabolic Activators on Memory Impairment in Old Rats
- EPILEPTOGENIC ACTIVITY INDUCED BY INTRAVENOUS INJECTION OF CERTAIN CEPHALOSPORINS IN RATS
- Effects of Ethanol, Acetoin and 2,3-Butanediol on EEG Power Spectra in Conscious Rats
- The Influence of the Protein Kinase A System in Differentiation of HL-60-Eo Cells to Eosinophils Induced by Histamine
- Effect of Methylcarbonylmethyl 2(S)-[4-(4-Guanidino-benzoyloxy)phenyl] Propionate Methanesulfonate (TT-S24) on Experimental Pancreatitis in Rats
- Inhibitory Effect of Levocabastine on Experimental Allergic Conjunctivitis in Guinea Pigs
- Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions(Pharmacology)
- Effects of Some H_1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate-Receptor Agonist on Histamine H_1 Receptor Antagonist-Induced Memory Deficit in Rats
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water
- Hypnotic Activities of Chamomile and Passiflora Extracts in Sleep-Disturbed Rats(Pharmacology)
- Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice(Biopharmacy)
- Regulatory Machanism of Eosinophil Peroxidase Release From Guinea Pig Eosinophils
- Histamine-Induced Cortisol Secretion from Bovine Adrenocortical Cells: Co-incubated with Bovine Adrenal Medullary Cells
- EFFCTS OF HISTAMINE AND ITS RELATED COMPOUNDS ON IMPAIRMENT OF PASSIVE AVOIDANCE RESPONSE FOLLOWING HIPPOCAMPAL LESIONS IN RATS
- Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance
- Effects of Antiepileptics on Lateral Geniculate Nucleus–Kindled Seizures in Rats
- EFFECTS OF n-DECYLAMINE AND TOLUIDINE BLUE ON THE ELECTRIC CAPACITANCE OF ISOLATED RAT MAST CELLS
- INFLUENCE OF HISTAMINE AND RELATED COMPOUNDS ON THE HYPNOTIC EFFECT OF THIOPENTAL IN MICE
- CATALEPTIC EFFECT OF HISTAMINE INDUCED BY INTRAVENTRICULAR INJECTION IN MICE
- SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
- NALOXONE-INDUCED ABSTINENCE SYNDROMES IN MORPHINE-TREATED MICE
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust
- EFFECTS OF ANTIDEPRESSANT DRUGS ON AMYGDALOID AFTER-DISCHARGE IN RATS
- DEGRANULATION AND HISTAMINE RELEASE IN FOCAL ANTIGEN-ANTI BODY REACTION BY MEANS OF MICROELECTROPHORESIS IN A SINGLE RAT MESENTERY MAST CELL
- EFFECTS OF PSYCHOTROPIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION BEHAVIOR IN RATS
- The Role of lons on Histamine-lnduced Depolarization in Isolated Guinea Pig Adipocytes.
- Structural Study of Ultrathin Hydrogenated Amorphous Carbon Films Using Spectroscopic Ellipsometry and Ultraviolet Raman Spectroscopy
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of intraventricular injection of histamine on the pinna reflex in mice.
- Inhibitory Effects of Emedastine Difumarate on Histamine Release.
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Histamine-Induced Depolarization and the Cyclic AMP-Protein Kinase A System in Isolated Guinea Pig Adipocytes.
- Changes in Self-Stimulation Response during Chronic Morphine Treatment and after Withdrawal of Morphine in Rats.