Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The anti-allergic effect of an ethanol extract from Moutan Cortex was evaluated in some animal models. The Moutan Cortex extract (30, 100mg/kg, i.p.) dose-dependently inhibited systemic anaphylactic shock induced by compound 48/80 in mice. It also inhibited dose-dependently the scratching behavior induced by compound 48/80 or histamine at a dose of 100 mg/kg. An increase in the vascular permeability induced by compound 48/80 or histamine was also inhibited by the Moutan Cortex. In addition, in vitro studies, the Moutan Cortex inhibited histamine release from rat peritoneal mast cells induced by compound 48/80. To investigate the active component of Moutan Cortex extract, it was suspended in water and extracted with EtOAc to yield EtOAc insoluble (A) and soluble (B) fractions. The effect of extract (B) was more potent than that of extract (A) in inhibiting histamine release. From these findings, it seems likely that the Moutan Cortex extract is effective in antagonizing certain pharmacological effects induced by compound 48/80, which is probably mediated by inhibiting the release of histamine from mast cells and antagonizing the effect on histamine. The main active component of Moutan Cortex is considered to be contained in extract (B). In conclusion, Moutan Cortex may be useful for the relief of symptoms of atopic dermatitis and other allergy-related diseases.
- 公益社団法人日本薬学会の論文
- 2007-09-01
著者
-
Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
NAKANO Yoshiyuki
Department of Applied Materials Science, Graduate School of Engineering, Osaka Prefecture University
-
Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
-
Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
-
Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
-
Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
-
Nakano Yoshiyuki
Department Of Applied Materials Science Graduate School Of Engineering Osaka Prefecture University
-
Ono Rie
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
-
JIANG Shuishi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
YATSUZUKA Rie
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
Nakano Yoshiyuki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Jiang Shuishi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Yatsuzuka Rie
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
関連論文
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate–Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats
- Participation of Prostaglandin E2 Receptor in Nasal Congestion of Brown Norway Rats
- Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task(Pharmacology)
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- Interaction between Hippocampal γ-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats
- Anticonvulsant Effect of (RS)-1-Aminoindan-1,5-dicarboxylic Acid on Pentetrazol-Induced Kindled Seizures in Mice
- Ferroelectricity in Li-Doped ZnO:X Thin Films and their Application in Optical Switching Devices
- Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
- Effects of Peppermint (Mentha piperita L.) Extracts on Experimental Allergic Rhinitis in Rats
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- Participation of GABAergic and Histaminergic Systems in Inhibiting Amygdaloid Kindled Seizures
- Slow Wave Sleep-inducing Effects of First Generation H_1-Antagonists
- Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia
- Preparation and Characterization of Two Crystalline Forms of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159)
- Synthesis and Pharmacological Activity of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159) and Its Optical Isomers
- Development of Amygdaloid Kindling in Histidine Decarboxylase-deficient and Histamine H_1 Receptor-deficient Mice
- Add-on polytherapy with antidepressants and its significance in inpatients with major depression
- Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust(Pharmacology)
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice
- Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
- Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate-Receptor Blockade
- Influences of Histamine H_1 Receptor Antagonists on Maximal Electroshock Seizure in Infant Rats(Pharmacology)
- Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats(Pharmacology)
- Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice
- Characteristic Effects of Anti-dementia Drugs on Rat Sleep Patterns
- Participation of Histamine H_3 Receptors in Experimental Allergic Rhinitis of Mice
- The Effects of Selective Serotonin-Reuptake Inhibitor on Visual Evoked Potential in Rats
- Comparative Study of Certain Antibiotics on Epileptogenic Property, Including (1Rpi, 5S, 6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a] [1,2,4] triazolium-6-yl)] thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate (LJC10627), a Carbapenem Antibiotic wit
- Mechanism of the Inhibitory Effect of Histamine on Amygdaloid-Kindled Seizures in Rats
- Effects of Fujibitol, a Remedy for Nasal Symptoms, on Experimental Allergic Rhinitis in Rats
- Characterization of ASK Mice, a Strain Highly Sensitive to Anaphylactic Shock
- Role of Substance P on Histamine H_3 Antagonist-Induced Scratching Behavior in Mice
- Caffeic Acid Inhibits Compound 48/80-Induced Allergic Symptoms in Mice(Pharmacology)
- Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats(Pharmacology)
- Influences of Everninomicin, Vancomycin and Teicoplanin on Chemical Mediator Release From Rat Peritoneal Mast Cells
- Increasing Effect by Simultaneous Use of Levocabastine and Pemirolast on Experimental Allergic Conjunctivitis in Rats(Pharmacology)
- DIFFERENTIAL ANTAGONISM OF ANTIAVOIDANCE, CATALEPTIC AND PTOTIC EFFECTS OF NEUROLEPTICS BY BIPERIDEN
- EFFECT OF NEUROLEPTIC DRUGS ON THE CONDITIONED BEHAVIOR AFTER PRETREATMENT WITH α-METHYLTYROSINE OR p-CHLOROPHENYLALANINE
- Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen
- Effects of Histidine on Working Memory Deficits Induced by the 5-HT_-Receptor Agonist 8-OH-DPAT
- Effect of Propolis Extract on D-Galactosamine-Induced Hepatic Injury in Rats
- Mechanism of Bradykinin-Induced Histamine Release from Rat Peritoneal Mast Cells
- Effects of Anti-dementia Drugs on Morphine-Induced Somnolence
- Effects of Hop Extracts on Nasal Rubbing and Sneezing in BALB/c Mice(Pharmacology)
- Effects of Antiepileptics on Lateral Geniculate Nucleus-Kindled Seizures in Rats
- Effects of a Dictamnus dasycarpus T. Extract on Allergic Models in Mice
- Effects of Various Antiepileptics on Behavioral and Electroencephalographic Seizures Induced by Maximal Electroshock in Mice
- Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions(Pharmacology)
- Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice(Pharmacology)
- Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in Mice
- Characteristics of Scratching Behavior Induced by Some Chemical Mediators in Hairless Mice
- Antipruritic and Antierythema Effects of Ascomycete Bulgaria inquinans Extract in ICR Mice(Pharmacology)
- Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on Nasal Rubbing and Scratching Behavior in ICR Mice(Pharmacology)
- Effects of Cholinergic Drugs and Cerebral Metabolic Activators on Memory Impairment in Old Rats
- EPILEPTOGENIC ACTIVITY INDUCED BY INTRAVENOUS INJECTION OF CERTAIN CEPHALOSPORINS IN RATS
- Delusions and hallucinations in patients with borderline personality disorder
- Effects of Ethanol, Acetoin and 2,3-Butanediol on EEG Power Spectra in Conscious Rats
- The Influence of the Protein Kinase A System in Differentiation of HL-60-Eo Cells to Eosinophils Induced by Histamine
- Effect of Methylcarbonylmethyl 2(S)-[4-(4-Guanidino-benzoyloxy)phenyl] Propionate Methanesulfonate (TT-S24) on Experimental Pancreatitis in Rats
- Inhibitory Effect of Levocabastine on Experimental Allergic Conjunctivitis in Guinea Pigs
- Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions(Pharmacology)
- Effects of Some H_1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate-Receptor Agonist on Histamine H_1 Receptor Antagonist-Induced Memory Deficit in Rats
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water
- Hypnotic Activities of Chamomile and Passiflora Extracts in Sleep-Disturbed Rats(Pharmacology)
- Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice(Biopharmacy)
- Regulatory Machanism of Eosinophil Peroxidase Release From Guinea Pig Eosinophils
- Histamine-Induced Cortisol Secretion from Bovine Adrenocortical Cells: Co-incubated with Bovine Adrenal Medullary Cells
- EFFCTS OF HISTAMINE AND ITS RELATED COMPOUNDS ON IMPAIRMENT OF PASSIVE AVOIDANCE RESPONSE FOLLOWING HIPPOCAMPAL LESIONS IN RATS
- Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance
- Effects of Antiepileptics on Lateral Geniculate Nucleus–Kindled Seizures in Rats
- INFLUENCE OF HISTAMINE AND RELATED COMPOUNDS ON THE HYPNOTIC EFFECT OF THIOPENTAL IN MICE
- CATALEPTIC EFFECT OF HISTAMINE INDUCED BY INTRAVENTRICULAR INJECTION IN MICE
- SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
- NALOXONE-INDUCED ABSTINENCE SYNDROMES IN MORPHINE-TREATED MICE
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust
- EFFECTS OF ANTIDEPRESSANT DRUGS ON AMYGDALOID AFTER-DISCHARGE IN RATS
- EFFECTS OF PSYCHOTROPIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION BEHAVIOR IN RATS
- The Role of lons on Histamine-lnduced Depolarization in Isolated Guinea Pig Adipocytes.
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of intraventricular injection of histamine on the pinna reflex in mice.
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Histamine-Induced Depolarization and the Cyclic AMP-Protein Kinase A System in Isolated Guinea Pig Adipocytes.
- Changes in Self-Stimulation Response during Chronic Morphine Treatment and after Withdrawal of Morphine in Rats.