Hypnotic Activities of Chamomile and Passiflora Extracts in Sleep-Disturbed Rats(Pharmacology)
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概要
- 論文の詳細を見る
In the present study, we investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats. A significant decrease in sleep latency was observed with chamomile extract at a dose of 300mg/kg, while passiflora extract showed no effects on sleep latency even at a dose of 3000mg/kg. No significant effects were observed with both herbal extracts on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Flumazenil, a benzodiazepine receptor antagonist, at a dose of 3mg/kg showed a significant antagonistic effect on the shortening in sleep latency induced by chamomile extract. No significant effects were observed with chamomile and passiflora extracts on delta activity during non-REM sleep. In conclusion, chamomile extract is a herb having benzodiazepine-like hypnotic activity.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Masuoka Takayoshi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Masuoka Takayoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Inoue T
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University:ogawa & Co. Ltd
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Shinomiya Kazuaki
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
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Shinomiya Kazuaki
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
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Inoue Toshio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Masuoka Takayoshi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Inoue Toshio
Dep. Of Pharmacotherapy Nihon Pharmaceutical Univ.
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Utsu Yoshiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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OHMORI Asae
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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INOUE Toshio
Material R&D Laboratory, Ogawa & Co., Ltd.
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Ohmori Asae
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Inoue Toshio
Material R&d Laboratory Ogawa & Co. Ltd.
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Tokunaga Shin
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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