HEART RATE-DEPENDENT ALTERATION OF THE FREQUENCY AND COUPLING INTERVAL OF VENTRICULAR ARRHYTHMIAS AS MEASURED BY 24-HOUR ECG MONITORING

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• Twenty-four hour ECG recordings of 132 patients with frequent (>1000/day) ventricular premature contractions (VPCs) were analyzed using a computerized system, designed to evaluate the relationships between 1) the VPC frequency and heart rate (HR) (VPC-HR relation), 2) the coupling interval (CI) of VPCs and HR (CI-HR relation), and 3) the incidence of ventricular tachycardia (VT) and HR (VT-HR relation). The patterns of the VPC-HR relation included: 1) an increase in VPCs with increasing HR (positive correlation, 43 patients), 2) an increase in VPCs at low HR range and a decrease at high HR range, with increasing HR (bidirectional correlation. 74 patients), 3) a decrease in VPCs with increasing HR (nagative correlation, 7 patients) and 4) constant VPCs over all HRs (flat correlation. 8 patients). Patients were divided into 2 broad categories according to whether they had a positive correlation (P group, 43 patients) or the other correlations (non-positive or NP group, 89 patients). Of 132 patients, the CI-HR relation was negative in 129 (98%) and positive in only 3 (2%). Patients with frequent VTs (10 or more events over 24h) were significantly more frequent in the P (9 patients. 21%) than in the NP group (7 patients, 8%, p<0.05). However, mean HR, mean CI, total VPC counts and the slope of CI-HR relation were not significantly different between the groups. The VT-HR relation observed in 16 patients with frequent VTs were positive in 9 of the P group and In 2 of the NP group and non-positive in 5 of the NP group. We conclude that: 1) the incidence of VTs depends on underlying HR, as was the case for VPCs, 2) in most (88%) patients, the occurrence of VPC and VT reveals similar dependence on the underlying HR, and 3) the CI of VPCs shortens as HR increases in most (98%) patients.

• 社団法人日本循環器学会の論文
• 1991-10-20

著者

• INOUE Toshio

  Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University

• ITO MORIO

  Department of Laboratory Medicine, Oita Medical University

• ARITA MAKOTO

  Department of Physiology, Oita Medical University

• Saikawa Tetsunori

  First department of Internal Medicine, Oita Medical University

• Arita M

  Department Of Cardiovascular Science Oita Medical University

• Arita M

  The Department Of Physiology Medical College Of Oita

• Saikawa Tetsunori

  First Department Of Internal Medicine Medical College Of Oita

• Ito Morio

  Department Of Laboratory Medicine School Of Medicine Oita Medical University

• Ito Morio

  Department Of Laboratory Medicine Oita Medical University

• Arita M

  Department Of Physiology Oita Medical University

• Arita Makoto

  Department Of Cardiovascular Science Oita Medical University

• Inoue Toshio

  Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph

• KOUMATSU KOUSEI

  Department of Laboratory Medicine, Oita Medical University

• ITO MORIO

  Kyushu Univ.

• Ito Morio

  Tottori Univ.

• Itoh Morio

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Koumatsu Kousei

  Department Of Laboratory Medicine Oita Medical University

• Koumatsu Kousei

  Department Of Internal Medicine Medical College Of Oita

• Ito Morio

  Oita Medical Univ. Oita

• Inoue Toshio

  Department Of Internal Medicine Oita Medical University

• Inoue Toshio

  Department Of Cardiology Yufuin Kohseinenkin Hospital

• Arita Makoto

  Department Of Cardiology Yufuin Kohseinenkin Hospital

• Inoue Takeshi

  Department Of Medicine Oita National Hospital

• Ito Morio

  Department Of Laboratory Medicine Medical Callege Of Oita

• Ito Morio

  Department of Health Care Center, Munakata Ishikai-Hospital

• KOUMATSU Kousei

  Department of Cardiology, Oita National Hospital

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