HEMODYNAMIC EFFECTS OF MILRINONE IN PATIENTS WITH CONGESTIVE HEART FAILURE : Short-and Long-term Follow Up Studies
スポンサーリンク
概要
- 論文の詳細を見る
The hemodynamic effects of milrinone (Mil) were studied in 11 patients with congestive heart failure (CHF) and New York Heart Association (NYHA) functional class II-IV before and after a 2-week treatment. The plasma concentration of Mil was also determined and its pharmacokinetics analyzed. The effect of a placebo was examined before the initiation of the treatment. At the onset, the hemodynamic effects of a single oral dose of Mil (7.5 mg) were evaluated. Mil increased the cardiac index significantly (p<0.05) 4 h after administrations from 2.3±0.4 to 2.9±0.6 L/min/m^2. The pulmonary capillary wedge pressure (PCW) was lowered significantly by Mil (p<0.05) between 0.5 and 4 h after administration. After a 2-week treatment, the baseline PCW dropped (p<0.05) and the NYHA functional class improved in 10 patients. One patient remained in the same class (II). The improved NYHA class was maintained in 6 patients tested after a mean interval of 16~3 months. Single oral administration of Mil (7.5 mg) induced hemodynamic improvements after 2-week treatment and the drug also induced similar improvements even after the chronic oral therapy with Mil for 16±3 months. Pharmacokinetic analysis showed a significant increase in the area under the curve after 2 weeks of treatment. We conclude that Mil decreases the PCW and probably increases the cardiac index and thus improves the symptoms and NYHA functional class in patients with CHF.
- 社団法人日本循環器学会の論文
- 1993-05-20
著者
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Saikawa Tetsunori
Department Of Cardiovascular Science Oita University
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Saikawa Tetsunori
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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Saikawa Tetsunori
First Department Of Internal Medicine Medical College Of Oita
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Maeda Toshihiro
Department Of Internal Medicine Oita Medical University
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Maeda Toshihiro
Department Of Anatomy Of Shiga University Of Medical Science
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Takaki Ryosaburo
Department Of Internal Medicine Oita Medical University
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Fukuoka Yoshisuke
Department Of Medicine Oita Prefectural Hospital
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Nanimatsu Hiroshi
Department of Internal Medicine, Medical College of Oita
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Nanimatsu Hiroshi
Department Of Medicine Oita Prefectural Hospital
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Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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