Gender Differences in the ST Segment : Effect of Androgen-Deprivation Therapy and Possible Role of Testosterone
スポンサーリンク
概要
- 論文の詳細を見る
Background: ST-segment elevation in a structurally normal heart is observed in Brugada- and early repolarization syndrome. The incidence of both syndromes is much higher in males than females. Clinical and basic studies suggest that testosterone plays an important role in ventricular repolarization. Methods and Results: Standard surface 12-lead electrocardiograms recorded in 640 healthy subjects were studied (310 males, 330 females ranging in age from 5 to 89 years) (Study 1). The 3 ST levels (ST-J, -M, and -E) were measured in leads V2 and V5, which are representative of the right and left ventricles, respectively. The effect of androgen-deprivation therapy on the ST segment was also evaluated in 21 prostate cancer patients (Study 2). In both leads, the 3 ST levels were significantly higher in adult males than females (P<0.0001) due to a marked increase after puberty in males. As their age increased, males manifested a gradual reduction in the ST level in both leads; in females, there was a reduction in lead V5 only. In both sexes, all 3 ST levels were significantly higher in lead V2 than V5 (P<0.0001). Androgen-deprivation therapy significantly decreased all 3 ST segments in both leads. Conclusions: Significant age- and gender differences in the ST segment in healthy adults were found, suggesting that testosterone modulates the early phase of ventricular repolarization. (Circ J 2010; 74: 2448-2454)
- 社団法人 日本循環器学会の論文
- 2010-10-25
著者
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Takahashi Naohiko
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
-
Yufu Kunio
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Nakagawa Mikiko
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Saikawa Tetsunori
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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中村 匡秀
神戸大学大学院工学研究科情報知能学専攻
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Mimata Hiromitsu
Department of Oncological Science (Urology), Oita University Faculty of Medicine
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Saikawa Tetsunori
Department Of Cardiovascular Science Oita University
-
Sakata Toshiie
大分医科大学 臨床検査医
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Namiki Mikio
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Saikawa Tetsunori
大分赤十字病院 循環器科
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Saikawa Tetsunori
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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Nakagawa Mikiko
Department Of Cardiovascular Science Oita University
-
Namiki Mikio
Department Of Integrated Cancer Therapy And Urology Kanazawa University Graduate School
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SATOH FUMINORI
Department of Urology, Oita Medical University
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Ezaki Kaori
Department of Laboratory Examination and Diagnostics Faculty of Medicine Oita University
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Teshima Yasushi
Department of Laboratory Examination and Diagnostics Faculty of Medicine Oita University
-
Taniguchi Yayoi
Department of Cardiovascular Science, Faculty of Medicine, Oita University
-
Teshima Yasushi
Department Of Cardiovascular Science Faculty Of Medicine
-
Taniguchi Yayoi
Department Of Cardiovascular Science Faculty Of Medicine Oita University
-
Takahashi Naohiko
Department Of Cardiology Tenshindo-hetsugi Hospital
-
Sakata Toshiie
Internal Medicine 1 School Of Medicine Oita University
-
Takahashi Naohiko
Departments Of Internal Medicine I Oita University School Of Medicine
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Yufu Kunio
Department Of Cardiovascular Science Faculty Of Medicine
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Saikawa Tetsunori
Department Of Clinical Examination And Diagnosis Oita University School Of Medicine
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Nomura Takeo
Department Of Urology Oita University School Of Medicine
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Sakata Toshiie
Department Of Internal Medicinel Oita Medical University
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NAGANO Yasuko
Department of Clinical Examination and Diagnosis, Oita University School of Medicine
-
Satoh Fuminori
Department Of Urology Oita Medical University
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Satoh Fuminori
Department Of Oncological Science (urology) Oita University Faculty Of Medicine
-
Tokuda Noriaki
Department Of Urology Saga Medical School
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Takahashi Naohiko
Department Of Clinical Examination And Diagnosis Oita University School Of Medicine
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Ezaki Kaori
Department Of Clinical Examination And Diagnosis Oita University School Of Medicine
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Mimata Hiromitsu
Department Of Urology Oita University School Of Medicine
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Mimata Hiromitsu
Urology Oita University Faculty Of Medicine
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Mimata Hiromitsu
Department Of Oncological Science (urology) Oita University
-
Mimata Hiromitsu
Departments Of Urology Oita Medical University
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SAKATA Toshiie
the First Department of Internal Medicine
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Nobori Takuo
Departments Of Otolaryngology Faculty Of Medicine Kagoshima University
-
Yamamoto Tokunori
Department Of Urology Nagoya University Graduate School Of Medicine
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Saikawa Tetsunori
Department Of Laboratory Medicine School Of Medicine Oita Medical University
-
Takahashi Naohiko
Department Of Internal Medicinel Oita Medical University
-
中村 匡秀
神戸大学大学院システム情報学研究科
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Nagano Yasuko
Department Of Clinical Examination And Diagnosis Oita University School Of Medicine
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Mimata Hiromitsu
Departments Of Urology Oita Medical University Oita And Kagoshima University Faculty Of Medicine
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Mimata Hiromitsu
Department Of Oncological Science Urology Faculty Of Medicine Oita University
-
Nomura Takeo
Department Of Oncological Science (urology) Oita University Faculty Of Medicine
-
Namiki Mikio
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
-
Takahashi Naohiko
Department Of Cardiovascular Science Faculty Of Medicine Oita University
-
Nomura Takeo
Department Of Internal Medicine Nippon Medical School
-
Namiki Mikio
Department Of Urology Kanazawa University Graduate School Of Medical Science
-
Sato Fuminori
Department Of Urology Oita Medical University
-
Nomura Takeo
Departments Of Urology Oita Medical University
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Morishita Hiroshi
Department Of Urology
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Naoi Makito
Department Of Urology Toho University Sakura Medical Center
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中村 匡秀
神戸大学大学院システム情報学研完科
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Taniguchi Yu
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of Medicine
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Nakamura Takashi
Institute Of Multidisciplinary Research For Advanced Materials Tohoku University
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Takahashi Naohiko
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Nakagawa Mikiko
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Teshima Yasushi
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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- PE-161 Smoking Disordered Tight Positive Correlation between Blood Pressure and Endothelium-Dependent Vasodilation in Young Healthy Subjects(Atherosclerosis, clinical(05)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circ
- PE-009 Redistribution of Gap Junctions in Pressure Overload-Induced Atrial Fibrillation Model Rats and Effects of Candesartan(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Increased Incidence of Coronary In-Stent Restenosis in Type 2 Diabetic Patients is Related to Elevated Serum Malondialdehyde-Modified Low-Density Lipoprotein
- Measurement of the Brachial-Ankle Pulse Wave Velocity and Flow-Mediated Dilatation in Young, Healthy Smokers