Baroreflex Sensitivity Predicts Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Without Structural Heart Disease
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概要
- 論文の詳細を見る
Background: Cardiovascular autonomic neuropathy is a major complication in patients with diabetes mellitus (DM). However, the relationship between cardiovascular autonomic neuropathy and the incidence of cardiovascular events has been poorly investigated in type 2 DM. The present study aimed to assess the long-term cardiovascular predictive value of baroreflex sensitivity (BRS) in Japanese patients with type 2 DM without structural heart disease. Methods and Results: BRS was evaluated using the phenylephrine method in 210 patients with type 2 DM who did not have structural heart disease or other severe complications. BRS was considered depressed if <6 ms/mmHg. Accurate follow-up information for 3-10 years (mean 4.7 years) was obtained in 184 patients (90 females, 94 males; mean age 58±12 years). The initial onset of a major adverse cardiovascular event (MACE) was investigated. During follow-up, 19 patients presented with a MACE (4 cardiovascular deaths, 3 nonfatal myocardial infarctions, 4 coronary revascularizations, 5 strokes, 2 congestive heart failures). Cox proportional hazards regression analysis revealed that depressed BRS was independently associated with the incidence of MACE (hazard ratio 1.93, 95% confidence interval 1.09-3.82, P=0.0236). Conclusions: Depressed BRS at baseline has long-term cardiovascular predictive value in Japanese patients with type 2 DM without structural heart disease. (Circ J 2010; 74: 1379 - 1383)
著者
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Okada Norihiro
Department of Internal Medicine 1, Faculty of Medicine, Oita University
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Takahashi Naohiko
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Yufu Kunio
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Murozono Yukichi
Department of Internal Medicine 1, Faculty of Medicine, Oita University
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Wakisaka Osamu
Department of Internal Medicine 1, Faculty of Medicine, Oita University
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Shinohara Tetsuji
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Anan Futoshi
Department of Internal Medicine 1, Faculty of Medicine, Oita University
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Nakagawa Mikiko
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Hara Masahide
Department of Internal Medicine 1, Faculty of Medicine, Oita University
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Saikawa Tetsunori
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Yoshimatsu Hironobu
Department of Internal Medicine 1, Faculty of Medicine, Oita University
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