Baroreflex Sensitivity Predicts Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Without Structural Heart Disease

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概要

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• biBackground:/i/b Cardiovascular autonomic neuropathy is a major complication in patients with diabetes mellitus (DM). However, the relationship between cardiovascular autonomic neuropathy and the incidence of cardiovascular events has been poorly investigated in type 2 DM. The present study aimed to assess the long-term cardiovascular predictive value of baroreflex sensitivity (BRS) in Japanese patients with type 2 DM without structural heart disease. biMethods and Results:/i/b BRS was evaluated using the phenylephrine method in 210 patients with type 2 DM who did not have structural heart disease or other severe complications. BRS was considered depressed if 6 ms/mmHg. Accurate follow-up information for 3-10 years (mean 4.7 years) was obtained in 184 patients (90 females, 94 males; mean age 58±12 years). The initial onset of a major adverse cardiovascular event (MACE) was investigated. During follow-up, 19 patients presented with a MACE (4 cardiovascular deaths, 3 nonfatal myocardial infarctions, 4 coronary revascularizations, 5 strokes, 2 congestive heart failures). Cox proportional hazards regression analysis revealed that depressed BRS was independently associated with the incidence of MACE (hazard ratio 1.93, 95% confidence interval 1.09-3.82, P=0.0236). biConclusions:/i/b Depressed BRS at baseline has long-term cardiovascular predictive value in Japanese patients with type 2 DM without structural heart disease.  (iCirc J/i 2010; b74:/b 1379 - 1383)br

• 社団法人　日本循環器学会の論文
• 2010-06-25

著者

• Okada Norihiro

  Department of Internal Medicine 1, Faculty of Medicine, Oita University

• Murozono Yukichi

  Department of Internal Medicine 1, Faculty of Medicine, Oita University

• Shinohara Tetsuji

  Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University

• Anan Futoshi

  Department of Internal Medicine 1, Faculty of Medicine, Oita University

• Okada Norihiro

  Department Of Internal Medicine 1 Faculty Of Medicine Oita Univercity

• 中村 匡秀

  神戸大学大学院工学研究科情報知能学専攻

• Saikawa Tetsunori

  Department Of Cardiovascular Science Oita University

• Sakata Toshiie

  大分医科大学 臨床検査医

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Saikawa Tetsunori

  大分赤十字病院 循環器科

• Saikawa Tetsunori

  Department Of Cardiovascular Science Faculty Of Medicine Oita University

• Anan Futoshi

  Department Of Cardiology Oita Red Cross Hospital

• Nakagawa Mikiko

  Department Of Cardiovascular Science Oita University

• Yoshimatsu Hironobu

  Department Of Anatomy Biology And Medicine (internal Medicine (i)) Faculty Of Medicine Oita Universi

• Namiki Mikio

  Department Of Integrated Cancer Therapy And Urology Kanazawa University Graduate School

• Murozono Yukichi

  Department Of Internal Medicine 1 Faculty Of Medicine Oita Univercity

• Takahashi Naohiko

  Department Of Cardiology Tenshindo-hetsugi Hospital

• Takahashi Naohiko

  Departments Of Internal Medicine I Oita University School Of Medicine

• Yufu Kunio

  Department Of Cardiovascular Science Faculty Of Medicine

• Saikawa Tetsunori

  Department Of Clinical Examination And Diagnosis Oita University School Of Medicine

• Sakata Toshiie

  Department Of Internal Medicinel Oita Medical University

• Wakisaka Osamu

  Department Of Internal Medicine 1 Faculty Of Medicine Oita Univercity

• Hara Masahide

  Department Of Internal Medicine I Faculty Of Medicine Oita University

• Hara Masahide

  Department Of Internal Medicine I School Of Medicine Oita Medical University

• Takahashi Naohiko

  Department Of Internal Medicinel Oita Medical University

• 中村 匡秀

  神戸大学大学院システム情報学研究科

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Takahashi Naohiko

  Department Of Cardiovascular Science Faculty Of Medicine Oita University

• Hara Masahide

  Department Of Internal Medicine 1 Faculty Of Medicine Oita University

• Namiki Mikio

  Department Of Urology Kanazawa University Graduate School Of Medical Science

• Naoi Makito

  Department Of Urology Toho University Sakura Medical Center

• 中村 匡秀

  神戸大学大学院システム情報学研完科

• Shinohara Tetsuji

  Department of Internal Medicine 1, Faculty of Medicine, Oita University

• Takahashi Naohiko

  Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University

• Shinohara Tetsuji

  Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University

• Saikawa Tetsunori

  Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University

• Nakagawa Mikiko

  Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University

• Wakisaka Osamu

  Department of Cardiology, Tokyo Women's Medical University

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