Ischemia-Induced Translocation of Protein Kinase C-ε Mediates Cardioprotection in the Streptozotocin-Induced Diabetic Rat
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概要
- 論文の詳細を見る
The present study investigated the role of translocation of protein kinase C (PKC) during ischemia/reperfusion in cardioprotection in the streptozotocin (STZ)-induced diabetic rat. Twelve weeks after injection of STZ or vehicle, male Wister-King rat hearts were isolated and perfused in the presence or absence of 50nmol/L staurosporine or 2μumol/L chelerythrine using a Langendorff apparatus. Thirty minutes of global ischemia was followed by the same period of reperfusion. The time to onset of contracture was determined during ischemia. The recovery of left ventricular function, incidence of ventricular tachycardia/fibrillation (VT/VF), and amount of released creatine kinase (CK) were determined during the reperfusion period. Translocation of the PKC-α, -β,-δ and -ε isoforms was determined by immunoblotting. Development of contracture was delayed, the recovery of left ventricular function was greater, and the incidence of VT/VF and amount of released CK were lower indiabetic than in control hearts. Ischemia caused an increase in the particulate/cytosolic fraction ratio of the PKC-ε isoform in the diabetic and control hearts. However, this translocation of PKC-ε during ischemia was transient in the control heart, but was persistent in the diabetic heart. The ischemia-induced translocation of PKC-ε was abolished by chelerythrine perfusion. These results suggest that persistent translocation of PKC-ε during ischemia plays a major role in cardioprotection against ischemia/reperfusion injury in STZ-induced diabetic rats.
- 社団法人日本循環器学会の論文
- 2003-10-20
著者
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Saikawa Tetsunori
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Sakata Toshiie
大分医科大学 臨床検査医
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Yoshimatsu Hironobu
Department Of Internal Medicine 1 Oita University
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Saikawa Tetsunori
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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OOIE Tatsuhiko
Department of Internal Medicine I, School of Medicine, Oita Medical University
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Ooie Tatsuhiko
Department Of Cardiology Oita Medical Center
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Hara Masahide
Internal Medicine 1, Faculty of Medicine, Oita University
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Yoshimatsu Hironobu
Internal Medicine 1, Faculty of Medicine, Oita University
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Shigematsu Sakuji
Department Of Cardiology Beppu Medical Center
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Takahashi Naohiko
Departments Of Internal Medicine I Oita University School Of Medicine
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Arikawa Masaya
Internal Medicine I School Of Medicine Oita Medical University
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Nawata Tomoko
Internal Medicine I School Of Medicine Oita Medical University
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Takahashi Naohiko
Internal Medicine, Oita Medical University
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Yamanaka Kunitoshi
Internal Medicine I, School of Medicine, Oita Medical University
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Kajimoto Munetaka
Departments of Laboratory Medicine, School of Medicine, Oita Medical University
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Shinohara Tetsuji
Internal Medicine I, School of Medicine, Oita Medical University
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Shigematsu Sakuji
Internal Medicine I, School of Medicine, Oita Medical University
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Takahashi Naohiko
Department Of Clinical Examination And Diagnosis Oita University School Of Medicine
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Kajimoto Munetaka
Departments Of Laboratory Medicine School Of Medicine Oita Medical University
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Takahashi Naohiko
Department Of Internal Medicinel Oita Medical University
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Yamanaka Kunitoshi
Department Of Internal Medicine 1 Faculty Of Medicine Oita University
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Takahashi Naohiko
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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