Electrophysiologic Effects of Diltiazem, a New Slow Channel Inhibitor, on Canine Cardiac Fibers
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概要
- 論文の詳細を見る
The effect of diltiazem hydrochloride (CRD-401), a coronary vasodilator, was investigated in isolated perfused canine ventricular muscles and Purkinje fibers using microelectrodes. The drug at a concentration of 1μg/ml lowered the level of action potential plateau and shortened the duration in both ventricular and Purkinje fibers without change in maximum rate of rise (Vmax) or resting potential. Contractile tension of ventricular muscle was markedly decreased with shortening of plateau. With higher drug concentration (5μg/ml), Vmax in both ventricular muscle and Purkinje fiber decreased about 20% without change in resting potential, and the effect on repolarization became more marked. The drug blocked spontaneous firing which appeared in depolarized Purkinje fibers and abolished the automaticity elicited in electrically depolarized ventricular muscles. Input resistance of ventricular muscle, measured by small, hyperpolarizing short pulses, was not changed appreciably by the drug; suggesting no change in potassium conductance. These results suggest that the drug is a slow channel inhibitor, and its clinical implication is discussed in terms of antiarrhythmic acitivty.
- International Heart Journal刊行会の論文
著者
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Saikawa Tetsunori
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Saikawa Tetsunori
Department Of Physiology Faculty Of Medicine Kyushu University
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Saikawa Tetsunori
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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ARITA MAKOTO
Department of Physiology, Oita Medical University
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Arita Makoto
Department Of Physiology Faculty Of Medicine Kyushu University
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NAGAMOTO YASUO
Department of Physiology Faculty of Medicine, Kyushu University
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Arita Makoto
Department Of Cardiovascular Science Oita Medical University
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Nagamoto Yasuo
Department Of Physiology Faculty Of Medicine Kyushu University
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Arita Makoto
Department Of Cardiology Yufuin Kohseinenkin Hospital
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Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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