Caffeine induces Ventricular Tachyarrhythmias Possible Due to Triggered Activity in Rabbits in Vivo
スポンサーリンク
概要
- 論文の詳細を見る
Caffeine induces delayed afterdepolarizations(DADs)and triggered activity in isolated cardiac tissue. We investigated the ability of caffeine to induce triggered ventricular arrhythmias in rabbits in vivo. During continuous infusion of caffeine at doses of 0.3 or 1.0 mg/kg per min, ventricular pacing was performed with 50 stimuli with a cycle length of 220 nsec(basic pacing train)every 5 min until ventricular tachycardia(VT)was induced. The effects of programmed stimulation and pharmacologic agents on the induction of ventricular ectopic beats(VEBs)were examined. Pacing protocols were carried out in the presence of vagal-induced slowing of sinus thythm. VT was induced by a basic pacing train during the infusion of caffeine at 1.0 mg/kg per min, but not at 0.3 mg/kg per min. An increase in the pacing tate or the number of stimuli resulted in 1)a decrease in the first postpacing interval, and 2)an increase in the number of postpacing VEBs, In duction of VT was suppressed by intravenous bolus injections of verapamil, propranolol and adenosine. At the time of the initial induction of VT, the plasma concentration of caffeine was 87±2 μg/ml and the plasma level of norepinephrine increased from 666±166 pg/ml at baseline to 1121±245 pg/ml. These results suggest that catecholamine-associated triggered activity may be responsible for caffeine-induced VT.
- 社団法人日本循環器学会の論文
- 1996-02-20
著者
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Takahashi Naohiko
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Saikawa Tetsunori
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University
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Sakata Toshiie
大分医科大学 臨床検査医
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Saikawa Tetsunori
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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FUJINO Takehiko
Institute of Health Science, Kyushu University
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ITO MORIO
Department of Laboratory Medicine, Oita Medical University
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Fujino Takao
Laboratory Medicine School Of Medicine Oita Medical University
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Fujino Takehiko
The First Department Of Internal Medicine School Of Medicine Kyushu University
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Fujino Takehiko
1st Dept. Of Intern. Med. Facult. Of Med. Kyushu Univ.
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Takahashi Naohiko
Department Of Cardiology Tenshindo-hetsugi Hospital
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Ito Morio
Department Of Laboratory Medicine School Of Medicine Oita Medical University
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Takahashi Naohiko
Departments Of Internal Medicine I Oita University School Of Medicine
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Ishida Shuji
Department of Botany, Faculty of Science, Kyoto University
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Ishida Shuji
Department Of Laboratory Medicine
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Ishida Shuji
Department Of Botany Faculty Of Science Kyoto University
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Ito Morio
Department Of Laboratory Medicine Oita Medical University
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FUJINO Takao
Department of Laboratory Medicine
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Akimitsu Tadafumi
Department of Internal Medicine, School of Medicine, Oita Medical University
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ITO MORIO
Kyushu Univ.
-
Ito Morio
Tottori Univ.
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Fujino Takehiko
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Itoh Morio
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
-
Takahashi Naohiko
Department Of Internal Medicinel Oita Medical University
-
Ito Morio
Oita Medical Univ. Oita
-
Takahashi Naohiko
Department Of Cardiovascular Science Faculty Of Medicine Oita University
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Akimitsu Tadafumi
Department Of Internal Medicine I School Of Medicine Oita University
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Akimitsu Tadafumi
Department Of Internal Medicine School Of Medicine Oita Medical University
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Ito Morio
Department Of Laboratory Medicine Medical Callege Of Oita
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Takahashi Naohiko
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Ito Morio
Department of Health Care Center, Munakata Ishikai-Hospital
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