CUMULATIVE EFFECTS OF HEART BEAT ON VENTRICULAR PREMATURE CONTRACTIONS SUGGESTING POSSIBLE INVOLVEMENT OF TRIGGERED ACTIVITY

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概要

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• We analyzed 24 h ECG recordings of 29 patients with frequent (>2000/day) ventricular premature contractions (VPCs) to evaluate: 1) the relationship between VPC frequency and heart rate (HR); 2) the relationship between the coupling interval (CI) of VPCs and HR; 3) the time course of changes in VPC frequency following an abrupt and sustained increase in HR; and 4) the effect of oral diltiazem (90 or 180 mg/day for 4 weeks) on VPCs. Based on the patterns of relationship between VPC frequency and HR, patients were divided into 2 groups: 1) 17 patients with a positive correlation, the P group (a linear increase in VPCs with increasing HRs); and 2) 12 patients with a non-positive correlation, the NP group. The NP group showed either a linear decrease in VPCs with increased HRS (4 patients) or an increase in VPCs at low HRS and a decrease at high HRS (8 patients). In all cases, an increased HR was associated with a shortening of CI. In the P group, changes in VPCs after an abrupt in-crease in HR showed 2 types: 1) delayed-ascent type, in which VPCs increased as the duration of HR increase was prolonged (cumulative effects of heart beat) (7 patients); and non-delayed-ascent type (10 patients). Diltiazem reduced VPCs≧75% in all of the 7 delayed-ascent-type patients, compared with 3 of the 10 non-delayed-ascent-type patients (p<0.05) and none of the 12 patients in the NP group (p<0.001). The VPCs of delayed-ascent type had several important features characteristic of delayed afterdepolarizations induced in animal experiments, suggesting that these VPCs may be due to delayed afterdepolarizations.

• 社団法人日本循環器学会の論文
• 1993-06-20

著者

• Saikawa Tetsunori

  Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University

• Saikawa Tetsunori

  Department Of Cardiovascular Science Faculty Of Medicine Oita University

• FUJINO Takehiko

  Institute of Health Science, Kyushu University

• ITO MORIO

  Department of Laboratory Medicine, Oita Medical University

• ARITA MAKOTO

  Department of Physiology, Oita Medical University

• Fujino Takao

  Laboratory Medicine School Of Medicine Oita Medical University

• Arita M

  Department Of Cardiovascular Science Oita Medical University

• Arita M

  The Department Of Physiology Medical College Of Oita

• Fujino Takehiko

  The First Department Of Internal Medicine School Of Medicine Kyushu University

• Fujino Takehiko

  1st Dept. Of Intern. Med. Facult. Of Med. Kyushu Univ.

• Ito Morio

  Department Of Laboratory Medicine School Of Medicine Oita Medical University

• Ito Morio

  Department Of Laboratory Medicine Oita Medical University

• Arita M

  Department Of Physiology Oita Medical University

• Arita Makoto

  Department Of Cardiovascular Science Oita Medical University

• FUJINO Takao

  Department of Laboratory Medicine

• KOUMATSU KOUSEI

  Department of Laboratory Medicine, Oita Medical University

• ITO MORIO

  Kyushu Univ.

• Ito Morio

  Tottori Univ.

• Fujino Takehiko

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Itoh Morio

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Koumatsu Kousei

  Department Of Laboratory Medicine Oita Medical University

• Koumatsu Kousei

  Department Of Internal Medicine Medical College Of Oita

• Ito Morio

  Oita Medical Univ. Oita

• Arita Makoto

  Department Of Cardiology Yufuin Kohseinenkin Hospital

• Ito Morio

  Department Of Laboratory Medicine Medical Callege Of Oita

• Saikawa Tetsunori

  Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University

• Ito Morio

  Department of Health Care Center, Munakata Ishikai-Hospital

• KOUMATSU Kousei

  Department of Cardiology, Oita National Hospital

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