Novel Strategy to Prevent Atrial Fibrosis and Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
To explore a novel strategy of preventing atrial fibrosis and atrial fibrillation (AF), we have established 3 appropriate experimental models of AF. Firstly, atrial fibrosis was induced by pressure overload by abdominal aortic constriction (AAC). AAC enhanced left atrial (LA) expression of monocyte chemoattractant protein-1. Scanning electron microscopy revealed that LA endothelial cells were irregularly hypertrophied, with disarrangement of lines of cells. Possible “arrested” leukocyte-derived cells were observed on the surface of LA endothelial cells. Treatment with pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, resulted in attenuation of pressure overload-induced LA fibrosis. Secondly, LA fibrosis was induced by continuous infusion of angiotensin II (AII). Repeated whole-body hyperthermia led to the induction of heat shock protein (HSP) 72, which resulted in attenuation of AII-induced LA fibrosis. Thirdly, atrial fibrosis was induced by 5/6 nephrectomy as a model of AF associated with chronic kidney disease. Because the amount of nicotinamide adenine dinucleotide phosphate oxidase was increased and the potent antioxidant agent was effective, oxidative stress may be involved in the pathogenesis of LA fibrosis and enhanced AF vulnerability in this model. These observations suggest that inflammatory profibrotic processes are essential for the development of atrial fibrosis in these 3 models. Pioglitazone, induction of HSPs and antioxidant agent could be novel therapeutic approaches to preventing atrial fibrosis and AF. (Circ J 2012; 76: 2318–2326)
- 2012-09-25
著者
-
Saikawa Tetsunori
Department Of Cardiovascular Science Oita University
-
Sakata Toshiie
大分医科大学 臨床検査医
-
Saikawa Tetsunori
大分赤十字病院 循環器科
-
Saikawa Tetsunori
Department Of Cardiovascular Science Faculty Of Medicine Oita University
-
Teshima Yasushi
Department of Laboratory Examination and Diagnostics Faculty of Medicine Oita University
-
Fukunaga Naoya
Department Of Cardiology Oita Red Cross Hospital
-
Teshima Yasushi
Department Of Cardiovascular Science Faculty Of Medicine
-
Takahashi Naohiko
Department Of Cardiology Tenshindo-hetsugi Hospital
-
Takahashi Naohiko
Departments Of Internal Medicine I Oita University School Of Medicine
-
Saikawa Tetsunori
Department Of Clinical Examination And Diagnosis Oita University School Of Medicine
-
Sakata Toshiie
Department Of Internal Medicinel Oita Medical University
-
Wakisaka Osamu
Department Of Internal Medicine 1 Faculty Of Medicine Oita Univercity
-
Hara Masahide
Department Of Internal Medicine I Faculty Of Medicine Oita University
-
Hara Masahide
Department Of Internal Medicine I School Of Medicine Oita Medical University
-
Takahashi Naohiko
Department Of Internal Medicinel Oita Medical University
-
Takahashi Naohiko
Department Of Cardiovascular Science Faculty Of Medicine Oita University
-
Hara Masahide
Department Of Internal Medicine 1 Faculty Of Medicine Oita University
-
Kume Osamu
Department Of Internal Medicine I Faculty Of Medicine Oita University
-
Kume Osamu
Department Of Internal Medicine 1 Oita University Faculty Of Medicine
-
Takahashi Naohiko
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Teshima Yasushi
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
-
Wakisaka Osamu
Department of Cardiology, Tokyo Women's Medical University
関連論文
- Improved Hypertrophic Obstructive Cardiomyopathy by Left Ventricular Apex Epicardial Pacing
- PE-220 Visceral Fat Accumulation is a Significant Risk Factor for White Matter Lesions in Japanese Type 2 Diabetic Patients(PE037,Obesity/SAS 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-398 Association of Dyslipidemia with Depressed Baroreflex Sensitivity Leads to Higher Incident of Cardiovascular Events in Type 2 Diabetic Patients(PE067,Lipid Disorders 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese
- OE-222 Combined Assessment of Baroreflex Sensitivity with 123I-MIBG Scintigraphic Findings Strengthens the Power of Predictive Value for Cardiovascular Events in Type2(OE38,Nuclear Cardiology (Others) (I),Oral Presentation (English),The 73rd Annual Scient
- Influence of Systolic Blood Pressure and Cigarette Smoking on Endothelial Function in Young Healthy People(Vascular Medicine)
- PE-024 Combination of Cilostazol and Bepridil, a Potential Anti-Fibrillation Medication in Patients with Idiopathic Ventricular Fibrillation(Arrhythmia, therapy(11)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation
- OE-098 Baroreflex Sensitivity Predicts Cardio- and Cerebrovascular Events in Type 2 Diabetic Patients(Autonomic nervous system(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-177 Regulators of Non-Elderly or Non-Stenotic Type Onset in Patients with Acute Myocardial Infarction(PJ030,Metabolic Syndrome 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Manifestation of ST-Segment Elevation in Right Precordial Leads during Ischemia at a Right Ventricular Outflow Tract Area in a Patient with Brugada Syndrome
- Role of Circadian Rhythmicity in the Heart Rate Variability Preceding Non-Sustained Ventricular Tachycardia
- Angiotensin-Converting Enzyme Inhibitor Up-Regulates Cardiac β-Receptors in Cultured Neonatal Rat Myocytes
- Suppression of Ventricular Premature Contractions Possibly Related to Triggered Activity by Oral Diltiazem and Atenolol : SYMPOSIUM ON VENTRICULAR ARRHYTHMIA : BASIC AND CLINICAL STUDIES : 50th Annual Scientific Session of the Japanese Circulation Society
- Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients
- PE-434 Adrenomedullin Improves Cardiac Akt phosphorylation and Tolerance against Ischemia : Reperfusion Injury in Streptozotocin-Induced Diabetic Heart(PE073,Myocardial Ischemia-reperfusion (Basic) (IHD),Poster Session (English),The 73rd Annual Scientific
- Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72
- Predictors for Prehypertension in Patients with Impaired Glucose Tolerance
- Postchallenge Plasma Glucose and Glycemic Spikes Are Associated with Pulse Pressure in Patients with Impaired Glucose Tolerance and Essential Hypertension
- PE-223 Adrenomedullin Improves Cardiac Expression of Heat-shock Protein(HSP72) and Tolerance against Ischemia/Reperfusion Injury(Myocardial ischemia/reperfusion, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Jap
- PE-161 Smoking Disordered Tight Positive Correlation between Blood Pressure and Endothelium-Dependent Vasodilation in Young Healthy Subjects(Atherosclerosis, clinical(05)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circ
- PE-009 Redistribution of Gap Junctions in Pressure Overload-Induced Atrial Fibrillation Model Rats and Effects of Candesartan(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Increased Incidence of Coronary In-Stent Restenosis in Type 2 Diabetic Patients is Related to Elevated Serum Malondialdehyde-Modified Low-Density Lipoprotein
- Measurement of the Brachial-Ankle Pulse Wave Velocity and Flow-Mediated Dilatation in Young, Healthy Smokers
- PE-382 Candesartan Improves Cardiac Expression of HSP72 and Tolerance against Ischemia/Reperfusion Injury in Heredity Insulin-Resistance Rat(Cardiovascular pharmacology, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Soci
- PE-069 Ischemic Postconditioning Potentiates Hyperthermia-Induced Cardioprotection against Ischemia/Reperfusion Injury in Rats(Myocardial ischemia/reperfusion, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-270 Low Dose of Candesartan Suppresses Atrial Fibrosis and Fibrillation Induced by Pressure Overload in Rat Heart(Arrhythmia, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-674 Visceral Fat Area are Associated with the Results of 123I-metaiodobenzylguanidine Myocardial Scintigraphy in Type 2 Diabetic Patients(Nuclear cardiology-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-644 Postchallenge Plasma Glucose and Glycemic Spikes are more Strongly Associated with Pulse Pressure than Insulin Resistance Level(Hypertension, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- High-Density Lipoprotein Cholesterol and Insulin Resistance Are Independent and Additive Markers of Left Ventricular Hypertrophy in Essential Hypertension
- Cardioprotection by streptozotocin-induced diabetes and insulin against ischemia/reperfusion injury in rats
- Predicting No-reflow Based on Angiographic Features of Lesions in Patients with Acute Myocardial Infarction
- Less ventricular arrhythmias and improved hemodynamic recovery in streptozotocin-induced diabetic rat heart following ischemia-reperfusion injury
- Gender Differences in the ST Segment : Effect of Androgen-Deprivation Therapy and Possible Role of Testosterone
- PJ-629 White Matter Lesions is Associated with the Results of 123I-metaiodobenzylguanidine Myocardial Scintigraphy in Type 2 Diabetic Patients(PJ106,Nuclear Cardiology (Others) (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japane
- PJ-561 Sex Hormone and Autonomic Function Modulate of ST Segment in the Early Repolarization Syndrome(PJ094,ECG/Body Surface Potential Mapping/Holter 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-032 Reactive Oxygen Species-mediated Pro-survival Pathway as a Mechanism of Cardioprotective Effects by Pravastatin(OE06,Myocardial Ischemia-reperfusion (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circul
- Early atorvastatin therapy improves cardiac function in patients with acute myocardial infarction
- PJ-483 Gender and Age Differences in ST-segment : Possible Role of Testosterone(ECG/Body surface potential mapping/Holter(06)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-430 Hyperhomocysteinemia is a significant risk factor for white matter lesions in Japanese Type 2 diabetic patients(Cerebrovascular circulation/Stroke(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
- Baroreflex Sensitivity Predicts the Induction of Ventricular Arrhythmias by Cesium Chloride in Rabbits
- Postrest Shortening of the Action Potential Duration in Rabbits : In Vitro and In Vivo Correlation
- Dynamics of QT Interval in a Patient With Long QT Syndrome and a Normal QT Interval
- Relationship between QT and RR intervals in patients with bradyarrhythmias
- Caffeine induces Ventricular Tachyarrhythmias Possible Due to Triggered Activity in Rabbits in Vivo
- Ischemia-Induced Translocation of Protein Kinase C-ε Mediates Cardioprotection in the Streptozotocin-Induced Diabetic Rat
- Effect of Constant and Intermittent Vagal Stimulation on the Heart Rate and Heart Rate Variability in Rabbits
- P399 LONG-TERM ELECTRICAL STIMULATION OF CARDIAC SYMPATHEIC NERVE SUPPRESSED CESIUM-INDUCED EARLY AFTERDEPOLARIZATIONS AND VENTRICULAR ARRHYTHMIAS IN RABBITS
- P289 HEART RATE DEPENDENCY OF VENTRICULAR PREMATURE CONTRACTIONS AND VENTRICULAR TACHYCARDIAS IN THE PATIENTS WITH IDIOPATHIC VENTRICULAR TACHYCARDIA
- 1075 ANGIOTENSIN-CONVERTING ENZYMES IMPROVE CARDIAC FUNCTION VIA BRADYKININ POTENTIATION
- 0652 EFFECTS OF CONTINUOUS AND INTERMITTENT VAGAL STIMULATION ON HEART RATE VARIABILITY IN RABBITS
- QT Interval Revisited : Not Just the Matter of "Interval," but "Dynamics, Variability and Morphology" Matter!
- Morphological varieties of the Purkinje fiber network in mammalian hearts, as revealed by light and electron microscopy
- PE-204 Measurement of Brachial-Ankle Pulse Wave Velocity and Flow-Mediated Dilatation in Young Healthy Smokers(Atherosclerosis, clinical-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-057 Gender Difference of Dynamics in Ventricular Repolarization Induced by Exercise in Healthy Subjects(ECG/Body surface potential mapping/Holter-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-491 Squatting Test is a Simple Tool to Assess Baroreflex Sensitivity in Diabetes Mellitus(Autonomic nervous system-5 (H) PJ83,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-604 Regulation of Cardiac Heat-shock Protein 72 (HSP72) Expression by Testosterone(Molecular biology, myocardium-2 (M) PE106,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-325 Heat-shock Protein 72 (HSP72) Prevents Angiotensin II-induced Atrial Fibrosis and Fibrillation in Rat Heart(Arrhythmia, basic-4 (A) PE55,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-076 Pioglitazone But Not Glibenclamide Improves Cardiac Expression of HSP72 and Tolerance against Ischemia/Reperfusion Injury in Hereditary Insulin Resistance Rat(Cardiovascular pharmacology, basic/clinical-3 (H) PE13,Poster Session (English),The 70th
- OE-029 Insulin Deficiency Potentiates Geranylgeranylacetone-Induced Heat Shock Protein 72 in Association with Protection against Ischemia/Reperfusion in Rat Heart(Myocardial ischemia-reperfusion, basic/clinical-1 (IHD) OE5,Oral Presentation (English),The
- Effects of Menstrual Cycle on QT Interval Dynamics and Autonomic Tone (ECG/Body Surface Potential Mapping/Holter 7 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Insulin Resistance on Qeranylgeranylacetone-Induced Expression of Heat Shock Protein 72 and Cardioprotection in High-Fat Diet Rats(Myocardial Ischemia-reperfusion, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
- Oral Administration of Geranylgeranylacetone Attenuates Endothelial Damage Induced by Ischemia/Reperfusion Injury in Rats
- Role of Mitochondrial K_ Channels in Geranylgeranylacetone-Induced Cardioprotection in Rat Hear
- Role of insulin resistance in nondipper essential hypertensive patients
- PJ-771 Role of Insulin Resistance and High Density Lipoprotein Cholesterol on Left Ventricular Hypertrophy in Essential Hypertension(Hypertension, clinical-12 (H) PJ134,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- Pravastatin attenuates leukocyte adhesion and inhibits proinflammatory cytokine production after ischemia/reperfusion by regulationg angiotensin II
- Spironolactone prevents leukocyte-endothelium interaction induced by schemia-reperfusion and regulates plasma angiotensin II
- Gender Difference in Baroreflex Sensitivity to Predict Cardiac and Cerebrovascular Events in Type 2 Diabetic Patients
- OJ-210 Pioglitazone shift circadian rhythm of blood pressure from nondipper to dipper type in type 2 diabetes mellitus(Hypertension, clinical(03)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- HEMODYNAMIC EFFECTS OF MILRINONE IN PATIENTS WITH CONGESTIVE HEART FAILURE : Short-and Long-term Follow Up Studies
- Progressive Facilitation of Antegrade Conduction via an Accessory Pathway in a Patient with Wolff-Parkinson-White Syndrome and Permanent Atrial Fibrillation
- Diazoxide-mediated Cardioprotection Depends on Phenotypic Consequence and Stage of H2O2-induced Response (Cardiovascular Pharmacology, Basic/Clinical 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Oral Geranylgeranylacetone Preserved Endothelial Dysfunction by Ischemia/Reperfusion in the Rat Heart : Role of PI3 Kinase and Rho Kinase (Endothelium/NO 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Impact of Low Plasma Adiponectin Level on Cardiovascular Autonomic Function in Type 2 Diabetes Mellitus in Men(Autonomic Nervous System 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Mitochondria Is a Target for Geranylgeranylacetone-Induced Cardioprotection Against Ischemia/Reperfusion in Rat Heart(Myocardial Ischemia-reperfusion, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Increased Pulse Pressure Is Associated with Postprandial Plasma Glucose Levels and Left Ventricular Hypertrophy in Never-Treated Essential Hypertensive Patients(Hypertension, Clinical 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation S
- Hyperglycemia Regulates Myocardiocyte Survival and Susceptibility to Oxidative Stress through Production of Reactive Oxygen Species in Mitochondria(Diabetes/Obesity 8 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Low Plasma HDL-Cholesterol Levels are Associated with Abnormal Cardiac I-Metaiodobenzylguanidine Scintigraphic Findings in Type 2 Diabetic Patients(Nuclear Cardiology 10 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Attenuated Heat-Shock Protein 72 Expression in Streptozotocin-Induced Diabetic Heart is Due to Inhibition of Pl3 Kinase/Akt/GSK3β Cascade Activation(Molecular Biology, Myocardium 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Cardiovascular Autonomic Dysfunction as a Risk for Cardiovascular Disease in Type 2 Diabetic Patients(Cardiovascular Disease Risk in Diabetes and Glucose Intolerance, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- In Vivo experiment, suppressing the alternans of action potential duration increases the threshold of ventricular fibrillation induced by burst stimuli
- PJ-254 Body Mass Index is Associated with Insulin Resistance and Cardiovascular Autonomic Function in Type 2 Diabetic Patients(Nuclear cardiology-4 (I) PJ43,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- PE-305 Elevated Serum Malondialdehyde-modified Low-density Lipoprotein Predicts the Increased Incidence of Coronary In-stent Restenosis in Type 2 Diabetic Patients(Restenosis, basic/clinical-3 (IHD) PE51,Poster Session (English),The 70th Anniversary Annua
- Cardioprotective Effects of Pravastatin Against Lethal Ventricular Arrhythmias Induced by Reperfusion in the Rat Heart
- 5 Role of Mitochondrial ROS Production Associated with Glucose Metabolism in Development of Diabetic Cardiomyopathy(Diabetic Cardiovascular Complications and Therapeutic Strategy, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- AT_1 Receptor Blockade Prevents Microvascular Dysfunction Induced by Ischemia/Reperfusion Injury
- Increase of Post-stenting Coronary Restenosis in Patients with Diabetes Mellitus Relates to an Elevated Serum Malondialdehydemodified Low Density Lipoprotein(Restenosis after Angioplasty, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the J
- PJ-591 Cardiovascular Autonomic Function in Type 2 Diabetic Patients with Microalbuminuria : Role of Insulin Resistance(Autonomic Nervous System 4 (H) : PJ99)(Poster Session (Japanese))
- PJ-441 Relationship between high-sensitivity C-reactive protein and cardiovascular autonomic function in type 2 diabetic patients(Diabetes/Obesity 3 (H) : PJ74)(Poster Session (Japanese))
- Role of Silent Cerebral White Matter Lesions in Pathogenesis of Essential Hypertensive Patients
- Candesartan, an Angiotensin Receptor Antagonist, Regressed Left Ventricular Hypertrophy in Association with an Improvement of Insulin Resistance
- Elevated Serum Malondialdehyde-Modified LDL Promotes Post-Stenting Restenosis in Moderate to Large Size Stent
- Dynamic U wave perturbation in patients with idiopathic ventricular tachycardia originating from right ventricular outflow tract
- Brain natriuretic peptide as a marker of autonomic dysfunction in type 2 diabetic patients
- Coronary plaque is a main source of elevated oxidized (malondialdehyde-modified) LDL in venous and coronary sinus blood
- -P494- THE RELATIONSHIP BETWEEN CORONARY ARTERY DISEASE AND SILENT CEREBRAL INFARCTION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- 0621 Angiographical Determination of the Strategy of Reperfusion Therapy : Intracoronary Thrombolysis of Direct PTCA?
- Leg Fat Percentage Correlates Negatively With Coronary Atherosclerosis
- Cardiac Iodine-123 Metaiodobenzylguanidine (^I-MIBG) Scintigraphy Parameter Predicts Cardiac and Cerebrovascular Events in Type 2 Diabetic Patients Without Structural Heart Disease
- Baroreflex Sensitivity Predicts Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Without Structural Heart Disease
- Novel Strategy to Prevent Atrial Fibrosis and Fibrillation