Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice
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概要
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The prophylactic use of anti-allergic drugs has been proposed to be effective in the treatment of seasonal allergic rhinitis in humans. However, there is little information regarding the prophylactic effect of thromboxane A2 (TXA2) receptor antagonist on allergic rhinitis. Recent studies revealed that a TXA2 receptor antagonist ramatroban could block the prostaglandin D2 (PGD2) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). In the present study, we investigated the prophylactic effects of the histamine H1 receptor antagonist epinastine and the TXA2 receptor antagonist ramatroban and seratrodast on mouse models of allergic rhinitis. Female BALB/c mice were sensitized by an intraperitoneal injection of ovalbumin and alum on days 0, 5, 14 and 21. Seven days later, mice were sensitized by intranasal application of ovalbumin thrice a week. Drugs were administered once a day from day 22. The severity of allergic rhinitis was assessed by determining the extent of 2 nasal allergic symptoms (sneezing and nasal rubbing). Histamine sensitivity and eosinophil infiltration into the nasal mucosa were also determined. Epinastine and ramatroban significantly reduced nasal symptoms and the number of eosinophils in the nasal mucosa. Seratrodast showed no effect on nasal symptoms and eosinophil infiltration into the nasal mucosa. In addition, histamine sensitivity was reduced by epinastine and ramatroban. These results indicate that epinastine and ramatroban induce the prophylactic effect on allergic rhinitis.
- 公益社団法人 日本薬学会の論文
著者
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INOUE Toshio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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SUGIMOTO Yukio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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Inoue T
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University:ogawa & Co. Ltd
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Inoue Toshio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Sugimoto Yukio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Suzuki Yuh
Department of Medicinal Pharmacology, Division of Pharmaceutical Sciences, Okayama University Gradua
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Yamamoto Atsuki
Department of Medicinal Pharmacology, Division of Pharmaceutical Sciences, Okayama University Gradua
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Suzuki Yuh
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Inoue Toshio
Department Of Internal Medicine Oita Medical University
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Inoue Toshio
Department Of Cardiology Yufuin Kohseinenkin Hospital
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Sugimoto Yukio
Department of Medicinal Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Inoue Toshio
Department of Pharmacotherapy, Nihon Pharmaceutical University
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Yamamoto Atsuki
Department of Medicinal Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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