Chemical Constituents of Coreopsis lanceolata L. and Their Physiological Activities
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概要
- 論文の詳細を見る
Petals from Coreopsis lanceolata L. were extracted in methanol and subjected to solvent-solvent partitioning to yield four fractions: hexane, diethyl ether, ethyl acetate, and aqueous. These fractions were screened using a 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay and an active oxygen inhibition assay. The ethyl acetate extract contained the highest level of active components. Four compounds isolated from this fraction by HPLC were screened for antioxidant activity and anti-allergic activity. Anti-allergic activity was assessed by measuring release of histamine from rat peritoneal mast cells. One compound, termed laceolin, was characterized by spectroscopic analysis, including extensive NMR and mass spectra. This compound had significant radical scavenging activity, with an SC50 (scavenging concentration of 50%) value of 2.6 μg/mL and superoxide dismutase activity of 46.2%.
- 日本油化学会の論文
著者
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Nomura Masato
Graduate School of Systems Engineering, Kinki University
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INOUE Toshio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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Okada Yoshiharu
Graduate School Of System Engineering Program In Systems Engineering Kinki Univ.
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Tanimoto Shinichi
Graduate School of System Engineering, Program in Systems Engineering, Kinki University
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Miyazawa Mitsuo
Interdisciplinary Graduate School of Science and Technology, Kinki University
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Inoue Toshio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Inoue Toshio
Department Of Internal Medicine Oita Medical University
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Inoue Toshio
Department Of Cardiology Yufuin Kohseinenkin Hospital
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Inoue Toshio
Department of Pharmacology and Pharmacotherapy, Nihon Pharmaceutical University
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Nomura Masato
Graduate School of System Engineering, Program in Systems Engineering, Kinki University
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