Effects of Fujibitol, a Remedy for Nasal Symptoms, on Experimental Allergic Rhinitis in Rats
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概要
- 論文の詳細を見る
The effects of Fujibitol, a preparation of crude drugs in wide clinical use for treatment of chronic rhinitis and empyema, on experimental allergic rhinitis in rats were studied. Fujibitol inhibited nasal allergic symptoms, i.e. sneezing and nasal rubbing, induced by antigen in sensitized animals. An increase in dye leakage into the nasal cavity induced by antigen was also inhibited by Fujibitol. On the other hand, no inhibitory effects were observed on either the nasal allergic symptoms or increase in dye leakage into the nasal cavity induced by histamine. However, Fujibitol was effective in inhibiting histamine release from the nasal cavity induced by antigen. Oxatomide used as positive control drug showed potent inhibitory effects on nasal symptoms and dye leakage into the nasal cavity induced by histamine and antigen. These results suggested that Fujibitol showed a remarkable protective effect against experimental rhinitis induced by antigen via inhibition of histamine release from the nasal cavity.
- 公益社団法人日本薬学会の論文
- 2000-09-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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Harada Michiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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SUGIMOTO Yukio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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OKUMA Chihiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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Okuma Chihiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Sugimoto Yukio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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TAGA Chiyomi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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Taga Chiyomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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KAKIMOTO Masanori
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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KOBAYASHI Yoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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Kakimoto Masanori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Kobayashi Yoko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Kobayashi Yoko
Department Of Biological Chemical Engineering Faculty Of Engineering Gunma University
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