Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions(Pharmacology)
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概要
- 論文の詳細を見る
In the present study, we investigated the changes of sleep parameters in rats with chronic constriction injury (CCI) under aversive conditions. The electroencephalogram (EEG) in the frontal cortex of CCI rats and electromyogram (EMG) were measured over 6h by placing rats on sandpaper as an aversive condition, to compare with rats placed on sawdust. Six days after CCI surgery, the rats exhibited significant mechanical allodynia, and also had neuropathic pain. When rats were placed on sawdust, no significant difference was observed between the CCI group and sham-operated control group in sleep latency, total waking time, total non-REM sleep time and total REM sleep time. On the other hand, when CCI rats were placed on sandpaper, a significant increase was observed in sleep latency and total waking time compared with the sham group ; however, no significant difference was observed in the total non-REM sleep time and total REM sleep time between these two groups. These results indicate that an important factor of sleep disturbance in CCI rats is not only damage to the nerves but also being under aversive conditions. In addition, it was found that CCI rats placed on sandpaper as an aversive condition can serve as a new sleep disturbance model.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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TOIDE Katsuo
Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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Takeda Yasuhiro
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Takeda Yasuhiro
Department Of Animal Science Utsunomiya University
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Shinomiya Kazuaki
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
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Shinomiya Kazuaki
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
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Toide Katsuo
Pfizer Global Research And Development Nagoya Laboratories Pfizer Inc.
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Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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YAMAMOTO Wataru
Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc.
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UTSU Yoshiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Utsu Yoshiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Yamamoto Wataru
Pfizer Global Research & Development Nagoya Laboratories Pfizer Japan Inc.
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Shimomiya Kazuaki
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Okayama University
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Tokunaga Shin
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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