Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
-
Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
Takeda Yasuhiro
Department of Life and Materials Engineering, Nagoya Institute of Technology
-
SHINOMIYA Kazuaki
Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okay
-
Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
-
Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Kawahara Yuzo
Morishita Jintan Co. Ltd.
-
TOKUNAGA Shin
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
Takeda Yasuhiro
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Takeda Yasuhiro
Department Of Animal Science Utsunomiya University
-
Nishida Norihisa
Morishita Jintan Co. Ltd.
-
Shinomiya Kazuaki
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
-
Shinomiya Kazuaki
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
-
Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Kubo Toshihiro
Morishita Jintan Co. Ltd.
-
Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
-
NIIMOTO Tsuyoshi
Morishita Jintan Co., Ltd.
-
OHNO Tohru
Morishita Jintan Co., Ltd.
-
MATSUURA Youichi
Morishita Jintan Co., Ltd.
-
Ohno Tohru
Morishita Jintan Co. Ltd.
-
Niimoto Tsuyoshi
Morishita Jintan Co. Ltd.
-
Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
-
Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Matsuura Youichi
Morishita Jintan Co. Ltd.
-
Tokunaga Shin
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
関連論文
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate–Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats
- Prediction of Mixing Pattern by Using Power Number Diagram in Baffled and Unbaffled Mixing Vessels
- Participation of Prostaglandin E2 Receptor in Nasal Congestion of Brown Norway Rats
- Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task(Pharmacology)
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- Interaction between Hippocampal γ-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats
- Anticonvulsant Effect of (RS)-1-Aminoindan-1,5-dicarboxylic Acid on Pentetrazol-Induced Kindled Seizures in Mice
- Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats
- Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
- Effects of Peppermint (Mentha piperita L.) Extracts on Experimental Allergic Rhinitis in Rats
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- Participation of GABAergic and Histaminergic Systems in Inhibiting Amygdaloid Kindled Seizures
- Slow Wave Sleep-inducing Effects of First Generation H_1-Antagonists
- Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia
- Major Isoforms of Starch Branching Enzymes in Premature Seeds of Kidney Bean (Phaseolus vulgaris L.)
- Preparation and Characterization of Two Crystalline Forms of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159)
- Synthesis and Pharmacological Activity of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159) and Its Optical Isomers
- Development of Amygdaloid Kindling in Histidine Decarboxylase-deficient and Histamine H_1 Receptor-deficient Mice
- Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust(Pharmacology)
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice
- The N-terminal region of the starch-branching enzyme from Phaseolus vulgaris L. is essential for optimal catalysis and structural stability
- Isolation and Characterization of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bonito Bowels
- Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bonito Bowels Autolysate
- Effects of Calmodulin and Calmodulin Antagonists on Neutral Ca^-ATPase in the Membrane Fraction of Human Milk
- Enzymatic Properties of Two Calcium-stimulated ATPases in the Neutral and Acidic pH Regions Found in the Membrane Fraction of Human Milk
- Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
- Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate-Receptor Blockade
- Influences of Histamine H_1 Receptor Antagonists on Maximal Electroshock Seizure in Infant Rats(Pharmacology)
- Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats(Pharmacology)
- Prediction of Mixing Pattern by Using Power Number Diagram in Baffled and Unbaffled Mixing Vessels
- Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice
- Characteristic Effects of Anti-dementia Drugs on Rat Sleep Patterns
- Participation of Histamine H_3 Receptors in Experimental Allergic Rhinitis of Mice
- The Effects of Selective Serotonin-Reuptake Inhibitor on Visual Evoked Potential in Rats
- Comparative Study of Certain Antibiotics on Epileptogenic Property, Including (1Rpi, 5S, 6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a] [1,2,4] triazolium-6-yl)] thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate (LJC10627), a Carbapenem Antibiotic wit
- Mechanism of the Inhibitory Effect of Histamine on Amygdaloid-Kindled Seizures in Rats
- Endothelium-Dependent Relaxation in Pulmonary Arteries of L-NAME-Treated Wistar and Stroke-Prone Spontaneously Hypertensive Rats
- Effects of Fujibitol, a Remedy for Nasal Symptoms, on Experimental Allergic Rhinitis in Rats
- Characterization of ASK Mice, a Strain Highly Sensitive to Anaphylactic Shock
- Role of Substance P on Histamine H_3 Antagonist-Induced Scratching Behavior in Mice
- Caffeic Acid Inhibits Compound 48/80-Induced Allergic Symptoms in Mice(Pharmacology)
- Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats(Pharmacology)
- Influences of Everninomicin, Vancomycin and Teicoplanin on Chemical Mediator Release From Rat Peritoneal Mast Cells
- Increasing Effect by Simultaneous Use of Levocabastine and Pemirolast on Experimental Allergic Conjunctivitis in Rats(Pharmacology)
- DIFFERENTIAL ANTAGONISM OF ANTIAVOIDANCE, CATALEPTIC AND PTOTIC EFFECTS OF NEUROLEPTICS BY BIPERIDEN
- EFFECT OF NEUROLEPTIC DRUGS ON THE CONDITIONED BEHAVIOR AFTER PRETREATMENT WITH α-METHYLTYROSINE OR p-CHLOROPHENYLALANINE
- Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen
- Effects of Histidine on Working Memory Deficits Induced by the 5-HT_-Receptor Agonist 8-OH-DPAT
- Effect of Propolis Extract on D-Galactosamine-Induced Hepatic Injury in Rats
- Mechanism of Bradykinin-Induced Histamine Release from Rat Peritoneal Mast Cells
- Effects of Anti-dementia Drugs on Morphine-Induced Somnolence
- Correlation of Power Consumption for Propeller and Pfaudler Type Impellers
- Effects of Hop Extracts on Nasal Rubbing and Sneezing in BALB/c Mice(Pharmacology)
- Effects of Antiepileptics on Lateral Geniculate Nucleus-Kindled Seizures in Rats
- Effects of a Dictamnus dasycarpus T. Extract on Allergic Models in Mice
- Effects of Various Antiepileptics on Behavioral and Electroencephalographic Seizures Induced by Maximal Electroshock in Mice
- Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions(Pharmacology)
- Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice(Pharmacology)
- Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in Mice
- Characteristics of Scratching Behavior Induced by Some Chemical Mediators in Hairless Mice
- Antipruritic and Antierythema Effects of Ascomycete Bulgaria inquinans Extract in ICR Mice(Pharmacology)
- Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on Nasal Rubbing and Scratching Behavior in ICR Mice(Pharmacology)
- Effects of Cholinergic Drugs and Cerebral Metabolic Activators on Memory Impairment in Old Rats
- EPILEPTOGENIC ACTIVITY INDUCED BY INTRAVENOUS INJECTION OF CERTAIN CEPHALOSPORINS IN RATS
- Effects of Ethanol, Acetoin and 2,3-Butanediol on EEG Power Spectra in Conscious Rats
- The Influence of the Protein Kinase A System in Differentiation of HL-60-Eo Cells to Eosinophils Induced by Histamine
- Effect of Methylcarbonylmethyl 2(S)-[4-(4-Guanidino-benzoyloxy)phenyl] Propionate Methanesulfonate (TT-S24) on Experimental Pancreatitis in Rats
- Inhibitory Effect of Levocabastine on Experimental Allergic Conjunctivitis in Guinea Pigs
- Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions(Pharmacology)
- Effects of Some H_1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate-Receptor Agonist on Histamine H_1 Receptor Antagonist-Induced Memory Deficit in Rats
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water
- Hypnotic Activities of Chamomile and Passiflora Extracts in Sleep-Disturbed Rats(Pharmacology)
- Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice(Biopharmacy)
- Regulatory Machanism of Eosinophil Peroxidase Release From Guinea Pig Eosinophils
- Histamine-Induced Cortisol Secretion from Bovine Adrenocortical Cells: Co-incubated with Bovine Adrenal Medullary Cells
- EFFCTS OF HISTAMINE AND ITS RELATED COMPOUNDS ON IMPAIRMENT OF PASSIVE AVOIDANCE RESPONSE FOLLOWING HIPPOCAMPAL LESIONS IN RATS
- Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance
- Effects of Antiepileptics on Lateral Geniculate Nucleus–Kindled Seizures in Rats
- INFLUENCE OF HISTAMINE AND RELATED COMPOUNDS ON THE HYPNOTIC EFFECT OF THIOPENTAL IN MICE
- CATALEPTIC EFFECT OF HISTAMINE INDUCED BY INTRAVENTRICULAR INJECTION IN MICE
- SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
- NALOXONE-INDUCED ABSTINENCE SYNDROMES IN MORPHINE-TREATED MICE
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust
- EFFECTS OF ANTIDEPRESSANT DRUGS ON AMYGDALOID AFTER-DISCHARGE IN RATS
- EFFECTS OF PSYCHOTROPIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION BEHAVIOR IN RATS
- Rescue Therapy with Tacrolimus for a Patient with Severe Ulcerative Colitis Refractory to Combination Leukocytapheresis and High-Dose Corticosteroid Therapy
- The Role of lons on Histamine-lnduced Depolarization in Isolated Guinea Pig Adipocytes.
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of intraventricular injection of histamine on the pinna reflex in mice.
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Histamine-Induced Depolarization and the Cyclic AMP-Protein Kinase A System in Isolated Guinea Pig Adipocytes.
- Changes in Self-Stimulation Response during Chronic Morphine Treatment and after Withdrawal of Morphine in Rats.