Effects of Ethanol, Acetoin and 2,3-Butanediol on EEG Power Spectra in Conscious Rats
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概要
- 論文の詳細を見る
Effects of ethanol, acetoin and 2,3-butanediol on the central nervous system (CNS) were investigated by using the analysis of EEG (electroencephalogram) spectral powers recorded at the frontal cortex in rats. High doses of ethanol were required for exhibiting an increase of EEG spectral powers in the delta (0-4Hz) and theta (4-8Hz) waves when it was given either orally or intravenously. On the other hand, when ethanol was injected intracerebroventricularly, the drug caused a potent increasing effect of EEG spectral powers. Both acetoin and 2,3-butanediol were found to increase in EEG spectral powers by oral and intravenous administrations at relatively low doses. In addition, acetoin and 2,3-butanediol were more effective than ethanol in increasing EEG spectral powers in the delta and theta bands after intracerebroventricular administration. From these findings it can be concluded that both acetoin and 2,3-butanediol have a potent CNS depressant effect.
- 公益社団法人日本薬学会の論文
- 1998-01-15
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Otsuka Masato
Department Of Pathology Osaka City University Graduate School Of Medicine
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Ohmori Shinji
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Otsuka Masato
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Izumo Takayuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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ICHIKI Chikako
Department of Pharmacology Faculty of Pharmaceutical Sciences, Okayama University
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SAITOU Kouichi
Department of Pharmacology Faculty of Pharmaceutical Sciences, Okayama University
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Saitou K
Okayama Univ. Okayama Jpn
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Ichiki Chikako
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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KAMEI Chiaki
Department of Pharmacology Faculty of Pharmaceutical Sciences, Okayama University
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