EFFECTS OF ANTIDEPRESSANT DRUGS ON AMYGDALOID AFTER-DISCHARGE IN RATS
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概要
- 論文の詳細を見る
Effects of antidepressant drugs on the amygdaloid after-discharge induced by stimulating the amygdala in rats implanted with chronic electrodes, were investigated in correlation with anti-muricidal effects as well as neurotoxicity. Tricyclic antidepressants such as amitriptyline, imipramine and nortriptyline markedly depressed both after-discharge and muricide at doses smaller than neurotoxic doses. The effect of PF-257 was also the same as tricyclic antidepressants. On the other hand, methamphetamine and pipradrol blocked the muricide at doses smaller than neurotoxic doses without depressing the amygdaloid after-discharge. Major tranquilizers, chlorpromazine and clozapine depressed both after-discharge and muricide only at doses larger than those which impaired rotarod performance. Haloperidol, on the contrary, depressed the after-discharge without selectively blocking the muricide. Minor tranquilizers, diazepam and chlordiazepoxide did not block the muricide at doses smaller than neurotoxic doses, although they showed a marked depression of the after-discharge.
- 公益社団法人 日本薬理学会の論文
著者
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Oka Makoto
Department Of Physics H-27 Tokyo Institute Of Technology
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Shimizu Masanao
Department Of Pharmacology Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Masuda Yoshinobu
Department Of Pharmacology Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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KAMEI Chiaki
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical, Co., Ltd.
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OKA Makoto
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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OKA Makoto
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical, Co., Ltd.
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