Histamine-Induced Depolarization and the Cyclic AMP-Protein Kinase A System in Isolated Guinea Pig Adipocytes.
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概要
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The relationship between histamine (Hi)-induced depolarization and the cyclic AMP system in adipocytes was studied in guinea pigs, which seem to be more sensitive than rats to Hi. Hi caused a dose-dependent depolarization in guinea pig mesenterial and epididymal adipocytes with EC<SUB>50</SUB> values of 1.69 × 10<SUP>-7</SUP> M and 1.19 × 10<SUP>-7</SUP> M, respectively. Guinea pig adipocytes were 280-750 times more sensitive than rat adipocytes to Hi. Isoproterenol, forskolin and 3-isobutyl-1-methylxanthine (IBMX) also caused a depolarization, and the slopes of the concentration response lines for these drugs were almost the same as that for Hi. Furthermore, pretreatment with these drugs resulted in a potentiation of Hi-induced depolarization at lower concentrations which are not effective when each drug is used alone. In addition, Hi-induced depolarization was inhibited by pretreatment with prostaglandin E<SUB>1</SUB> (PGE<SUB>1</SUB>) and insulin dose-dependently. The content of cyclic AMP in adipocytes was increased by Hi (10<SUP>-7</SUP> M) in association with a decrease in membrane potential. KT5720, a protein kinase A inhibitor, which provides no significant effect even at a concentration of 10<SUP>-6</SUP> M, showed an antagonistic effect on Hi-induced depolarization.
- 公益社団法人 日本薬理学会の論文
著者
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Tasaka Kenji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Mukai Tomohito
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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