Rapid Coronary Vasodilation by Nitroglycerin Tapes
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概要
- 論文の詳細を見る
We analyzed the acute, direct effects of nitroglycerin (NTG) tape on the coronary arteries and hemodynamics in 38 patients who underwent coronary angiography. The diameters of the 3 main coronary arteries were compared among the angiograms obtained at baseline, 15 minutes following transdermal administration of 10mg (8 patients) or 25mg (30 patients) of NTG (Millisrol tape®), and after intracoronary injection of 2.5mg isosorbide dinitrate (ISDN). Only the left main trunk and proximal portion of the left anterior descending artery dilated after 10mg of transdermal NTG administration (p<0.05). However, every measured coronary segment (segments 1-8, 11, and 13) dilated (p<0.05) after 25mg of NTG. Systemic blood pressure decreased slightly but significantly from 150±22 to 147±21mmHg during the study, with no change in heart rate. Left ventricular end-diastolic pressure decreased significantly from 16±7 to 14±5mmHg. We conclude that 25mg of transdermal NTG tape dilates coronary arteries and is applicable for acute coronary syndrome, with few complications.
- International Heart Journal刊行会の論文
著者
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Hara Masahide
Department of Internal Medicine 1, Faculty of Medicine, Oita University
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INOUE Takeshi
Departments of Pathology, Osaka City General Hospital
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Sakata Toshiie
First Department Of Internal Medicine School Of Medicine Oita Medical University
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Saikawa Tetsunori
First department of Internal Medicine, Oita Medical University
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Saikawa Tetsunori
First Department Of Internal Medicine Medical College Of Oita
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TSUNEMATSU Yoshihiro
Health Insurance Nankai Hospital
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Koumatsu Kousei
Department Of Internal Medicine Medical College Of Oita
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TSUNEMATSU Yoshihiro
Department of Internal Medicine, Health Insurance Nankai Hospital
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MAEDA Toshihiro
First Department of Internal Medicine, Oita Medical University
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ITO Kenichiro
First Department of Internal Medicine, Oita Medical University
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NAWATA Tomoko
First Department of Internal Medicine, Oita Medical University
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Hara Masahide
Department Of Internal Medicine 1 Faculty Of Medicine Oita University
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Inoue Takeshi
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Inoue Takeshi
Department Of Animal Husbandry Faculty Of Agriculture Tohoku University
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SAKATA Toshiie
First Department of Internal Medicine, Oita Medical University
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HARA Masahide
Department of Internal Medicine, Health Insurance Nankai Hospital
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KOUMATSU Kousei
Department of Cardiology, Oita National Hospital
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