Apoptotic Cell Death in Neurons and Glial Cells : Implications for Alzheimer's Disease
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概要
- 論文の詳細を見る
It is now generally accepted that massive neuronal death due to oxidative stress is a common characteristic of brains in neurodegenerative disease. Recently, numerous apoptosis-regulating factors and multiple pathways have been identified, and apoptotic cell death has been implicated in neuronal loss in Alzheimers disease. Although glial cells are more resistant to oxidative stress than neurons, extensive oxidative stress seems to cause apoptotic cell death in glial cells. In fact, signs of apoptosis are observed in both neurons and glial cells in the brains of patients with Alzheimers disease. This review summarizes current findings regarding apoptotic processes and discusses the possible involvement of apoptosis-regulating factors in the pathology of Alzheimers disease.
- 社団法人 日本薬理学会の論文
著者
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Taniguchi Takashi
Department of Geophysics, Faculty of Science, Hokkaido University
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Taniguchi T
Department Of Neurobiology Kyoto Pharmaceutical University
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Taniguchi Takashi
京都薬科大学 病態生理学
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Shimohama Shun
Department of Neurology, Sapporo Medical University School of Medicine
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Shimohama S
Kyoto Univ. Kyoto Jpn
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Shimohama Shun
Department Of Neurology Faculty Of Medicine Kyoto University
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Takenawa Tadaomi
Division Of Biochemistry Institute Of Medical Science University Of Tokyo
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive
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Kitamura Y
Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn
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Taira Takahiro
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
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Takano T
Dep. Of Neurobiology Kyoto Pharmaceutical Univ.
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Taniguchi Takashi
Department Of Geophysics Faculty Of Science Hokkaido University
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Taniguchi Takashi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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TANIGUCHI Takashi
Department of Computational Science and Engineering, Nagoya University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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Taniguchi Takashi
Department of Biology, Kyoto Pharmaceutical University
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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