Response of Serum Carboxylated and Undercarboxylated Osteocalcin to Risedronate Monotherapy and Combined Therapy with Vitamin K2 in Corticosteroid-Treated Patients: A Pilot Study
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概要
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Objective The aim of this study was to investigate the responses of serum osteocalcin (OC), undercarboxylated osteocalcin (ucOC) and N-terminal telopeptide of type I collagen (NTx) to corticosteroids, and to examine the effects of risedronate therapy with or without vitamin K2 supplementation on bone metabolic markers in corticosteroid-treated patients. Methods Sixteen patients on corticosteroid therapy for neuromuscular disorders were assigned randomly to 2 groups (A: risedronate monotherapy, n=8; B: combined risedronate and vitamin K2 therapy, n=8) and treated for 1 year. Another 6 patients who received intravenous steroid pulse therapy were assigned to group C for investigation of the effects of corticosteroids on OC and ucOC 1 month after pulse therapy. Results Serial measurements revealed that significant decreases of OC, ucOC and NTx persisted with a similar time course profile during 1 year of treatment in groups A and B, and between-group analysis failed to demonstrate any additional effects of vitamin K2 on risedronate therapy. Intravenous steroid pulse therapy induced a transient depression of OC and ucOC within 1 week in group C. Conclusion These results indicate that serum concentrations of OC and ucOC become consistently low during corticosteroid administration despite risedronate therapy with or without vitamin K2 supplementation, and the serum ucOC level may not be a reliable indicator of vitamin K status under corticosteroid administration.
著者
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HAYASHI Takashi
Department of Materials Science, Shonan Institute of Technology
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Hozuki Takayoshi
Department of Neurology, Sapporo Medical University School of Medicine
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Imai Tomihiro
Department of Neurology, Sapporo Medical University School of Medicine
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Tsuda Emiko
Department of Neurology, Sapporo Medical University School of Medicine
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Matsumura Akihiro
Department of Neurology, Sapporo Medical University School of Medicine
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Yamamoto Daisuke
Department of Neurology, Sapporo Medical University School of Medicine
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Toyoshima Takanobu
Department of Neurology, Sapporo Medical University School of Medicine
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Suzuki Syuuichiro
Department of Neurology, Sapporo Medical University School of Medicine
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Yamauchi Rika
Department of Neurology, Sapporo Medical University School of Medicine
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Hisahara Shin
Department of Neurology, Sapporo Medical University School of Medicine
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Shimohama Shun
Department of Neurology, Sapporo Medical University School of Medicine
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Tsuda Emiko
Department Of Neurology Sapporo Medical University School Of Medicine
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Hisahara Shin
Department Of Neuroanatomy Biomedical Research Center Osaka University Medical School
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Imai Tomihiro
Department Of Neurology Sapporo Medical University School Of Medicine
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Shimohama Shun
Department Of Neurology Faculty Of Medicine Kyoto University
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Hozuki Takayoshi
Department Of Neurology Sapporo Medical University School Of Medicine
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Hayashi Takashi
Department Of Applied Chemistry Graduate School Of Engineering Osaka University
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Yamamoto Daisuke
Department Of Acoustic Design Kyushu Institute Of Design
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Matsumura Akihiro
Department of Frontier Materials, Nagoya Institute of Technology, Nagoya 466-8555, Japan
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