Interleukin-10-Induced CCR5 Expression in Macrophage Like HL-60 Cells: Involvement of Erk1/2 and STAT-3(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
As an immunosuppressive and anti-inflammatory cytokine, IL-10 was recently reported to play roles in CCR5 expression in human monocytes. CCR5 promoter regions contain Oct-2, TCF-lα, GATA, and STAT binding sites. Here, we studied the signals involved in the CCR5 expression in IL-10-stimulated cells using the HL-60 cell line. HL-60 cells were stimulated with PMA and differentiated to macrophage-like cells, then stimulated with IL-10. IL-10 induced significant expression of CCR5 protein and CCR5 mRNA in these cells. The induction of CCR5 by IL-10 was inhibited by a MEK-1 inhibitor, PD98059. In addition, IL-10 induced tyrosine (Tyr) phosphorylation of Erk, as well as serine (Ser) and Tyr phosphorylation of STAT-3. Tyr phosphorylation of Erk and Ser phosphorylation of STAT-3 were inhibited by PD98059, while Tyr phosphorylation of STAT-3 was not inhibited by PD98059. DNA binding activity of STAT-3 was observed by the stimulation with IL-10, which was inhibited by PD98059. These results first indicate that Erk1/2 and STAT-3 regulate CCR5 expression, and that Erk-mediated phosphorylation of Ser is required for full stimulation of STAT-3 in CCR5 expression.
- 公益社団法人日本薬学会の論文
- 2003-08-01
著者
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Yamamoto Daisuke
Department of Neurology, Sapporo Medical University School of Medicine
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Matsumoto-mishima Yuko
癌研究会癌化学療法センター 臨床研究部
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Kobayashi Takayuki
Cancer Inst. Hospital Tokyo Jpn
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AIZU-YOKOTA Eriko
Department of Biochemistry, Kyoritsu University of Pharmacy
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SONODA Yoshiko
Department of Biochemistry, Kyoritsu University of Pharmacy
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KASAHARA Tadashi
Department of Biochemistry, Kyoritsu University of Pharmacy
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Takebe Yutaka
National Institute Of Aids Research
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Aizu‐yokota E
Department Of Biochemistry Kyoritsu University Of Pharmacy
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Sonoda Y
Department Of Biochemistry Kyoritsu University Of Pharmacy
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Sonoda Yoshiko
Department Of Biochemistry And Immunology Kyoritsu University Of Pharmacy
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Kasahara T
Department Of Biochemistry Kyoritsu University Of Pharmacy
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Kasahara Tadashi
Department Of Biochemistry And Immunology Kyoritsu University Of Pharmacy
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MAKUTA Yoko
Department of Biochemistry, Kyoritsu College of Pharmac
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FUNAKOSHI-TAGO Megumi
Department of Biochemistry, Kyoritsu College of Pharmac
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Makuta Yoko
Department Of Biochemistry Kyoritsu College Of Pharmac
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Takahashi Kaoru
Department Of Breast Oncology Cancer Institute Hospital Of Japanese Foundation For Cancer Research
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Funakoshi-tago Megumi
Department Of Biochemistry Kyoritsu College Of Pharmac
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Yamamoto Daisuke
Department Of Mathematics And Physics Graduate School Of Natural Science And Technology Kanazawa Uni
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Yamamoto Daisuke
Department Of Biochemistry Kyoritsu College Of Pharmac
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Takagi Koichi
Department Of Medical Oncology Cancer Institute Hospital Of Japanese Foundation For Cancer Research
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Yamamoto Daisuke
Department Of Acoustic Design Kyushu Institute Of Design
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