Senile Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders : a Mini Review
スポンサーリンク
概要
- 論文の詳細を見る
Epstein-Barr virus (EBV) is associated with a number of malignant lymphomas, including Burkitt lymphomas, Hodgkin lymphomas (HLS), immunodeficiency-associated lymphoproliferative disorders (LPDs), and subset of diffuse large B-cell lymphomas. We have recently identified a series of elderly patients afflicted with EBV-associated (EBV-positive) B-cell LPDs in the absence of predisposing immunodeficiencies ; we have named these neoplasms “senile” EBV+ B-cell LPDs. The large series of patients with this disease (n=76) provided additional evidence that this neoplasia, with a median age of onset of 71 years, has the highest incidence in elderly patients aged > 50 years, suggesting that this disease may be related to the immunological deterioration that occurs during the aging process. These lesions were pathologically characterized by varying numbers of Hodgkin and Reed-Sternberg (HRS)-like giant cells, often posing a diagnostic problem differentiating this condition from HL. Recent studies, however, have indicated that HL and non-Hodgkin lymphoma (NHL) may be more closely related than previously implied, promoting the general consensus that HRS cells are derived from B cells in most HL cases. The relationship between EBV+ HL and EBV+ B-cell LPDs remains to be clarified. This review provides a unique opportunity to highlight the gray areas between EBV+ HL and EBV+ B-cell LPDs. Further investigations are necessary to clarify the interrelationship, including their overlapping morphological and biological features.
- 日本リンパ網内系学会の論文
- 2006-03-01
著者
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ASOU Norio
Department of Hematology, Kumamoto University School of Medicine
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MORISHIMA Yasuo
Department of Hematology and Cell Therapy, Aichi Cancer Center
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KAGAMI Yoshitoyo
Department of Hematology and Cell Therapy, Aichi Cancer Center
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NAKAMURA Shigeo
Department of Clinical Pathology, Aichi Cancer Center Hospital
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ASANO Naoko
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center
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Nakamura Shigeo
群馬県立がんセンター 病理検査
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Kishimoto Yuji
The First Department Of Internal Medicine Kansai Medical University
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Kagami Y
Department Of Hematology Japanese Red Cross Nagoya First Hospital
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Kagami Yoshitoyo
名古屋大学医学部附属病院 病理部
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Yamamoto Kazuhito
Department Of Hematology And Cell Therapy Aichi Cancer Center Hospital
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Kanakura Yuzuru
大阪大学 医学系研究科心臓血管外科
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Asou Norio
愛知県がんセンター
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Asou N
Department Of Hematology Kumamoto University School Of Medicine
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Asou Norio
Department Of Pathology And Molecular Diagnostics Aichi Cancer Center
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Asou Norio
Department Of Hematology And Infectious Diseases Kumamoto University Graduate School Of Medical Scie
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Suzuki R
Department Of Hsct Data Management Nagoya University Hospital
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Suzuki Ritsurou
東京大学医学部附属病院 無菌治療部
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Suzuki Ritsuro
豊橋市民病院 血液･腫瘍内科
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Suzuki Ritsuro
Division Of Molecular Medicine Aichi Cancer Center
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Matsumoto-mishima Yuko
癌研究会癌化学療法センター 臨床研究部
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Kawase Yoshiaki
Department Of Internal Medicine Japanese Red Cross Nagoya First Hospital
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OSHIRO Aya
Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital
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OYAMA Takashi
Department of Medical Oncology, Aichi Cancer Center
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SHIMOYAMA Yoshie
Department of Pathology and Clinical Laboratories, Nagoya University Hospital
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Nakamura S
Department Of Pathology And Clinical Laboratories Nagoya University Hospital
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Nakamura Shigeo
Department Of Pathology Nagoya University School Of Medicine
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Asou Norio
Department Of Hematology Kumamoto University School Of Medicine
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Nakamura Shigeo
Department Of Pathology Nagoya University Graduate School Of Medicine
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Suzuki Ritsurou
Department Of Hematology And Chemotherapy Aichi Cancer Center
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Morishima Yasuo
Department Of Hematology And Chemotherapy
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Oyama Takashi
Department Of Hematology Nagoya Daini Red Cross Hospital
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Kagami Yoshitoyo
Department Of Pathology School Of Medicine Kurume University
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Asano Naoko
Department Of Anesthesiology Iwate Medical University School Of Medicine
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Oshiro Aya
Department Of Hematology And Cell Therapy Aichi Cancer Center Hospital
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Morishima Yasuo
Department Of Hematology And Cell Therapy Aichi Cancer Center
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Kagami Yoshitoyo
Department Of Hematology And Cell Therapy Aichi Cancer Center
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Oyama Takashi
Department Of Medical Oncology Aichi Cancer Center
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Suzuki Ritsuro
Department Of Hsct Data Management And Biostatistics Nagoya University School Of Medicine
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Yano Kunio
県西部浜松医療センター
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Shimoyama Yoshie
Department Of Pathology And Clinical Laboratories Nagoya University Graduate School Of Medicine
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Oyama Takashi
Department Of Hematology And Oncology Nagoya Daini Red Cross Hospital
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Morishima Yasuo
Department Of Pathology And Oncology Institute Of Medical Science University Of Tokyo
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Asano Naoko
Department Of Laboratory Medicine Shinshu University Hospital
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Asano Naoko
Department Of Pathology And Molecular Diagnostics Aichi Cancer Center
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Nakamura Shigeo
Department Of Cardiovascular Diseases. Kokura National Hospital
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Suzuki Risturo
Division Of Molecular Medicine Aichi Cancer Center Research Institute
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NAKAMURA Shigeo
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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