Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the safety of water-soluble polymer-enwrapped fullerenes (PVP/fullerenes) as antioxidants in cosmetic and pharmaceutical preparations by studying the genotoxicity, phototoxicity, and pro-oxidant effects of these fullerenes. These materials were not mutagenic to any of the tested bacterial strains and did not induce chromosomal aberrations in cultured mammalian cells. The PVP/fullerenes did not exhibit cytotoxicity under ultraviolet or sham irradiation in the alternative phototoxicity test. Moreover, they did not show any pro-oxidant effect in the presence of Fe2+ or Cu2+. Thus, we concluded that PVP/fullerenes are safe for use in cosmetic and pharmaceutical applications. This is the first study in which toxicity tests were performed on PVP/fullerenes.
- 2010-06-01
著者
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AOSHIMA HISAE
Vitamin C60 BioResearch Corporation
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YAMANA SHUICHI
Vitamin C60 BioResearch Corporation
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NAKAMURA Shigeo
Department of Clinical Pathology, Aichi Cancer Center Hospital
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MASHINO Tadahiko
Department of Pharmaceutical Sciences Faculty of Pharmacy, Keio University
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Nakamura Shigeo
Department Of Pathology Nagoya University School Of Medicine
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Aoshima Hisae
Vitamin C60 Bioresearch Corp.
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Yamana Shuichi
Vitamin C60 Bioresearch Corp.
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Mashino Tadahiko
Department Of Pharmaceutical Sciences Faculty Of Pharmacy Keio University
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Nakamura Shigeo
Department Of Pharmaceutical Sciences Faculty Of Pharmacy Keio University
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Nakamura Shigeo
Department Of Cardiovascular Diseases. Kokura National Hospital
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NAKAMURA Shigeo
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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