Antimicrobial Activity of Fullerenes and Their Hydroxylated Derivatives

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概要

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• The antimicrobial activities of fullerene C60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. The tested samples were water-soluble fullerenes (polyvinylpyrrolidone (PVP)/C60, γ-cyclodextrin (γ-CD)/C60, and nano-C60) and 3 types of fullerenols (C60(OH)12, C60(OH)36·8H2O, and C60(OH)44·8H2O). Their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint of future application to cosmetics. Although pristine C60 demonstrated no antimicrobial activity, fullerenols exhibited good antimicrobial activity against Propionibacterium acnes, Staphylococcus epidermidis, Candida albicans, and Malassezia furfur. In particular, C60(OH)44 exhibited a strong and wide-ranging antimicrobial activity comparable to that of catechin. This compound exhibits antimicrobial activity via inhibition of microbial cell growth and not via bactericidal activity.

• 2009-06-10

著者

• AOSHIMA HISAE

  Vitamin C60 BioResearch Corporation

• KOKUBO KEN

  Division of Applied Chemistry, Graduate School of Engineering, Osaka University

• SHIRAKAWA SHOGO

  Division of Applied Chemistry, Graduate School of Engineering, Osaka University

• ITO MASAYUKI

  Vitamin C60 BioResearch Corporation

• YAMANA SHUICHI

  Vitamin C60 BioResearch Corporation

• OSHIMA TAKUMI

  Division of Applied Chemistry, Graduate School of Engineering, Osaka University

• Aoshima Hisae

  Vitamin C60 Bioresearch Corp.

• Yamana Shuichi

  Vitamin C60 Bioresearch Corp.

• Oshima Takumi

  Division Of Applied Chemistry Graduate School Of Engineering Osaka University

• Kokubo Ken

  Division Of Applied Chemistry Graduate School Of Engineering Osaka University

• Shirakawa Shogo

  Division Of Applied Chemistry Graduate School Of Engineering Osaka University

関連論文

• Antimicrobial Activity of Fullerenes and Their Hydroxylated Derivatives
• Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity
• Preparation of Hydrophilic Nanoparticles of C_ with High Resistance to Aggregation during Storage, using 2-Hydroxypropyl-β-cyclodextrin
• Safety evaluation of highly purified fullerenes (HPFs) : based on screening of eye and skin damage
• SAFETY EVALUATION OF A HEAVY OIL-DEGRADING BACTERIUM, RHODOCOCCUS ERYTHROPOLIS C2.
• Improvement of heavy oil degradation by Rhodococcus erythropolis C2
• Antioxidant Activity of Supramolecular Water-Soluble Fullerenes Evaluated by β-Carotene Bleaching Assay
• C11 Effect of Fullerene Poly-hydroxide on Cu-CMP Process(Abrasive finishing technology)

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