Involvement of Wiskott-Albrich Syndrome Protein Family Verprolin- Homologous Protein (WAVEAa9 and Rac1 in the Phagocytosis of Amyloid-β(1-42) in Rat Microglia
スポンサーリンク
概要
- 論文の詳細を見る
Alzheimer’s disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) fibrils with microglia. Recently, there has been great interest in the microglial phagocytosis of Aβ, because the microglial pathway is considered to be one of the Aβ clearance pathways in the brain parenchyma. However, the mechanism of microglial phagocytosis of Aβ is not fully understood and, thus, was investigated in this study. At one minute after exposure to Aβ(1 – 42) (Aβ42), Aβ immunoreactivity was detected at the cell surface of microglia. After 1 h, marked immunoreactivity was observed in the cytosolic vesicles. At 12 h, delayed phagocytosis of fibrillar Aβ42 was also observed with the formation of a large phagocytic cup. The microglial cell shape rapidly changed to an ameboid form during the process of phagocytosis. Although neither neural Wiskott-Aldrich syndrome protein (N-WASP) nor WASP interacting SH3 protein (WISH) immunoreactivity was co-localized with filamentous actin (F-actin) distribution, both WASP family verprolin-homologous protein (WAVE) and Rac1 immunoreactivity was co-localized with F-actin in the lamellipodia of phogocytic microglia. These results suggest that WAVE and Rac1 participate in the phagocytosis of Aβ42 by microglia.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
-
Takata Kazuyuki
Faculty Of Pharmaceutical Sciences Hoshi University
-
Taniguchi Takashi
Department of Geophysics, Faculty of Science, Hokkaido University
-
Taniguchi T
Department Of Neurobiology Kyoto Pharmaceutical University
-
Takahashi Kazunori
京都薬科大学 病態生理学
-
Taniguchi Takashi
京都薬科大学 病態生理学
-
Shimohama Shun
Department of Neurology, Sapporo Medical University School of Medicine
-
KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
-
TAKENAWA Tadaomi
Division of Biochemistry, Department of Cancer Biology, Institute of Medical Science, University of
-
Shimohama S
Kyoto Univ. Kyoto Jpn
-
Shimohama Shun
Department Of Neurology Faculty Of Medicine Kyoto University
-
TAKATA Kazuyuki
Department of Neurobiology, Kyoto Pharmaceutical University
-
TSUCHIYA Daiju
Department of Neurobiology, Kyoto Pharmaceutical University
-
GEBICKE-HAERTER Peter
Department of Psychopharmacology, Central Institute of Mental Health
-
Tsuchiya Daiju
Department Of Neurobiology 21st Century Coe Program Kyoto Pharmaceutical University
-
Takata Kazuyuki
Department Of Mechanical Engineering Aichi Institute Of Technology
-
MIKI Hiroaki
Division of Biochemistry, Institute of Medical Science, University of Tokyo
-
SHIBAGAKI Keiichi
Department of Neurobiology, Kyoto Pharmaceutical University
-
Takeuchi Kosei
Kan Research Institute Inc. Kobe Mi R&d Center
-
Takenawa Tadaomi
Division Of Biochemistry Institute Of Medical Science University Of Tokyo
-
Kanai Yoshihito
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
-
Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
-
Kitamura Yoshihisa
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive
-
Gebicke-haerter Peter
Department Of Psychopharmacology Central Institute Of Mental Health
-
Kitamura Y
Department Of Neurobiology Kyoto Pharmaceutical University
-
Kitamura Y
Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn
-
Miki Hiroaki
Division Of Biochemistry Institute Of Medical Science University Of Tokyo
-
Taira Takahiro
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
-
Takano T
Dep. Of Neurobiology Kyoto Pharmaceutical Univ.
-
Taniguchi Takashi
Department Of Geophysics Faculty Of Science Hokkaido University
-
Takenawa Tadaomi
Division Of Biochemistry Department Of Cancer Biology Institute Of Medical Science University Of Tok
-
Shibagaki Keiichi
Department Of Neurobiology Kyoto Pharmaceutical University
-
Taniguchi Takashi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
-
Takata Kazuyuki
Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University
-
TANIGUCHI Takashi
Department of Computational Science and Engineering, Nagoya University
-
Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
-
Taniguchi Takashi
Department of Biology, Kyoto Pharmaceutical University
-
KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
関連論文
- Response of Serum Carboxylated and Undercarboxylated Osteocalcin to Risedronate Monotherapy and Combined Therapy with Vitamin K2 in Corticosteroid-Treated Patients: A Pilot Study
- Identification of a Novel Planarian G-Protein-Coupled Receptor That Responds to Serotonin in Xenopus laevis Oocytes
- Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson's Disease-Linked PARK7
- DJ-1 binds to mitochondrial complex I and maintains its activity
- Chemical Compositions of Aerosol Particles and Snowfalls at Alta, Northern Norway
- Chemical Characteristics of Atmospheric Aerosol Particles on a High Mountain and an Urban Area in Sapporo, Japan
- Chemical Compositions of Atmospheric Aerosol Particles in Relation to the Wind Direction in Winter Season, Sapporo, Japan
- Chemical Compositions of Atmospheric Aerosol Particles in Relation to the Wind Direction at a High Mountain and Urban Area in Sapporo, Japan
- Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN
- Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
- Disruption of Phospholipase Cδ4 Gene Modulates the Liver Regeneration in Cooperation with Nuclear Protein Kinase C
- Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method
- Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice
- Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats
- Anisotropy in Storage Modulus of Magnetic Gels Induced by Magnetization
- New design of N-isopropyl-p-[^I]iodoamphetamine (^I-IMP) lung imaging in the patient with lung cancer
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7
- Uniaxial Elongational Viscosity of PC/ A Small Amount of PTFE Blend
- Massive Epistaxis From a Thrombosed Intracavernous Internal Carotid Artery Aneurysm 2 Years After the Initial Diagnosis : Case Report
- Proteasome Inhibitors Protect Against Degeneration of Nigral Dopaminergic Neurons in Hemiparkinsonian Rats
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-△^ Prostaglandin J_2-Sensitive Microglial Activation
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- The Parkinsonian Models : Invertebrates to Mammals
- Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation
- Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model
- Neurotrophic Effect of Hepatic Growth Factor (HGF) on Reinnervation of Perivascular Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves Following Phenol-Induced Nerve Injury in the Rat Mesenteric Artery
- Effect of Diazepam on the Runway Method Using Priming Stimulation of Intracranial Self Stimulation Behavior
- The 5-HT_ Receptor Full Agonist, 8-OH-DPAT Inhibits ACTH-Induced 5-HT_ Receptor Hyperfunction in Rats : Involvement of 5-HT_ Receptors in the DOI-Induced Wet-Dog Shakes in ACTH-Treated Rats(Pharmacology)
- Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone-Treated Rats Are Not Affected by Chronic Imipramine Treatment : Possible Involvement of Enhanced 5-HT_-Receptor Expression in the Frontal Cortex
- Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus
- Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells
- DJ-1, a Target Protein for an Endocrine Disrupter, Participates in the Fertilization in Mice
- Possible Involvement of P2X_7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats(Pharmacology)
- Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica
- Distribution of DJ-1, Parkinson's Disease-Related Protein PARK7, and Its Alteration in 6-Hydroxydopamine-Treated Hemiparkinsonian Rat Brain
- Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia
- FUNCTIONAL ASSAY OF DOPAMINERGIC AND SEROTONINERGIC NEURONS IN PLANARIAN(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Intracerebroventricular Injection of Microglia Protects Against Focal Brain Ischemia
- Possible Involvement of Both Endoplasmic Reticulum -and Mitochondria-Dependent Pathways in Thapsigargin-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
- Involvement of Wiskott-Albrich Syndrome Protein Family Verprolin- Homologous Protein (WAVEAa9 and Rac1 in the Phagocytosis of Amyloid-β(1-42) in Rat Microglia
- Apoptotic Cell Death in Neurons and Glial Cells : Implications for Alzheimer's Disease
- Possible Involvement of Rapamycin-Sensitive Pathway in Bcl-2 Expression in Human Neuroblastoma SH-SY5Y Cells
- Motivational Effect of Nomifensine in the Intracranial Self-Stimulation Behavior Using a Runway Method(Pharmacology)
- Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone-Treated Rats
- Motivational Effects of Methamphetamine as Measured by the Runway Method Using Priming Stimulation of Intracranial Self-stimulation Behavior(Analytical Biochemistry)
- Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test : Involvement of the Expression of 5-HT_ Receptor mRNA(Pharmacology)
- Nuclear reorganization during dedifferentiation of differentiated cells(Joint Symposium of the Society of Chromosome Research and the Chromosome Colloquium : "Dynamics of genome and chromosomes-aspects from gene expression to evolution-",Abstracts of the
- Structural Analysis of Nuclear Reprogramming during Newt Dedifferentiation Process(From Model Laboratory Species to Model Wild Species; the Next Generation of Model Animals Derived from Japan, but Applicable Worldwide: Japanese Wood Mouse, Japanese Medaka
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- CLATHRIN-DEPENDENT ENDOCYTOSIS REQUIRED FOR NEURONAL CELL SURVIVAL IN PLANARIAN(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- STUDY OF GENES REQUIRED FOR BRAIN REGENERATION AND NEURONAL MAINTENANCE IN PLANARIAN(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Antiparkinsonian Drugs and Their Neuroprotective Effects
- Protective Effect of Talipexole on MPTP-Treated Planarian, a Unique Parkinsonian Worm Model
- Hypersomnia Caused by Isolated Angiitis of the CNS
- Structure and Characterization of AAT-1 Isoforms(Biochemistry/Molecular Biology)
- Demonstration of Acidic Fibroblast Growth Factor (FGF-1) in Rat Adrenal Gland
- 5-Hydroxytryptamine-induced Ca^-independent cGMP formation is mediated by nitric oxide in a nitric oxide synthase-independent manner in NG108-15 cells
- Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Regulation of Actin Dynamics by WASP Family Proteins
- Transient Oculomotor Palsy Correlated with Nerve Enhancement on MRI in Chronic Inflammatory Demyelinating Polyneuropathy
- Photoproduction of η Mesons from Protons at Incident Energies below 1 GeV
- Assessment of Protein Kinase C mRNA Levels in Alzheimer's Disease Brains
- Improvement of Mechanical Properties for Poly (L-lactic acid) Film through Drawing Process Optimization
- Fatigue Properties of TiNi Shape Memory Alloy
- Abundance of Low Molecular Weight Phosphotyrosine Protein Phosphatase in the Nerve-Ending Fraction in the Brain
- Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
- Inhibitory Effects of Talipexole and Pramipexole on MPTP-InducedDopamine Reduction in the Striatum of C57BL/6N Mice
- EFFECTS OF CDP-CHOLINE ON STRIATAL DOPAMINE LEVEL AND BEHAVIOR IN RATS
- ON THE SNOW CRYSTALS OF LOW TEMPERATURE TYPES
- Alterations of Phospholipase C Isozymes in Rat Cerebral Cortex through Hyperoxia
- Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
- Characterization of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Resistance Arteries
- Nerve Growth Factor Suppresses Prostate Tumor Growth
- Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
- WASP and WAVE family proteins : Friends or foes in cancer invasion?
- The Hydroxyl Radical Formation System in Polymorphonuclear Leukocytes
- Participation of Cytosolic Protein Phosphatase in Regulation of NADPH Oxidase in Polymorphonuclear Leukocytes
- Zinc-Ion-Dependent Acid Phosphatase Exhibits Magnesium-Ion-Dependent myo-Inositol-1-phosphatase Activity
- Characterization of High- and Low-Molecular Weight Zinc-Dependent Acid Phosphatases in Bovine Liver
- Effect of Pharmacist Management on Serum Hemoglobin Levels with Renal Anemia in Hemodialysis Outpatients
- Maps of Lakes' Thermal Regimes in Japan
- New Molecular Mechanisms for Cardiovascular Disease:Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- Clinical Outcome of Patients with SREDA (Subclinical Rhythmic EEG Discharge of Adults)
- Noradrenaline Release Enhanced by Cholera Toxin and Pertussis Toxin in Rat Cerebral Cortical Slices
- Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7
- Nicotinic Receptor-Mediated Neuroprotection in Neurodegenerative Disease Models(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- New Molecular Mechanisms for Cardiovascular Disease : Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- Measurements of the number concentration of aerosol particles in northern Norway (abstract)
- Detoxification of 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration by 5,5-Dimethyl-1-pyrroline N-Oxide, a Radical Trapper, in Hemiparkinsonian Rats
- Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Tangle Formation, Amyloid-β, and Microglia in Alzheimer's Disease
- Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK7
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Effect of Selective Serotonin Reuptake Inhibitors via 5-HT_ Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model
- Detoxification of 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration by 5,5-Dimethyl-1-pyrroline N-Oxide, a Radical Trapper, in Hemiparkinsonian Rats
- Effect of Selective Serotonin Reuptake Inhibitors via 5-HT1A Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model
- Thyrotoxic Myopathy Mimicking Myasthenic Syndrome Associated with Thymic Hyperplasia
- Gluten Sensitivity in Japanese Patients with Adultonset Cerebellar Ataxia
- Reassessment of (3H)glutamate binding to human brain membrane preparations.