Noradrenaline Release Enhanced by Cholera Toxin and Pertussis Toxin in Rat Cerebral Cortical Slices
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概要
- 論文の詳細を見る
The effects of cholera and pertussis toxin on the release of noradrenaline (NA) were studied in the rat cerebral cortex. The cerebral cortical slices were incubated with cholera or pertussis toxin for 2 h, subsequently loaded with 1-[^3H] NA and superfused continuously. The pretreatment with cholera toxin significantly (p<0.05) enhanced the 20mM KCl-evoked [^3H] NA release. In contrast to a significant (p<0.05) increase in [^3H] NA release by pertussis toxin, neither A-protomer nor B-oligomer of the toxin could affect the release. These results suggest that cholera and pertussis toxin-substrates, probably guanosine triphosphate-binding proteins, could be involved in the NA release in the central nervous system.
- 公益社団法人日本薬学会の論文
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive
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QI Shangbin
Department of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical Uni
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Qi Shangbin
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive
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Nomura Yasuyuki
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University:department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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