Involvement of Polyubiquitin Chains via Specific Chain Linkages in Stress Response in Mammalian Cells(Biochemistry)
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概要
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Polyubiquitination plays key roles in various proteasome-dependent and independent cellular events. To elucidate roles in stress response of polyubiquitin chains formed via specific chain linkages in mammalian cells, we established NIH3T3 stable cell lines that are capable of conditionally expressing K29R, K48R and K63R ubiquitin mutants, in which the Lys29, Lys48 and Lys63 residues of ubiquitin had been changed to Arg, and we examined the effects of various stresses on their cell viabilities. The expression of K63R ubiquitin mutant decreased viability of the cells post-exposed to ethanol, H_2O_2 and methyl methanesulfonate (MMS), while that of K48R mutant decreased viability of the cells post-exposed to heat shock as well as ethanol, H_2O_2 and MMS. Thus, these results suggest that polyubiquitin chains formed via specific chain linkages are involved in the respective stress responses in mammalian cells.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Nishiya Tadashi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Nomura Yasuyuki
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Yokosawa Hideyoshi
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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Fujimuro Masahiro
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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Yokosawa Hideyoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Nishiya Tadashi
Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine
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Nishiya Tadashi
Department Of Cellular Pharmacology Graduate School Of Medicine Hokkaido University
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Fujimuro Masahiro
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University
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