An Unusual Case of Chronic Relapsing Tetanus Associated with Mandibular Osteomyelitis
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概要
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A 55-year-old man underwent radiation therapy due to malignant lymphoma of the neck. Eight years after the therapy he developed tetanus. It appears that the radiation therapy resulted in mandibular necrosis, and that this lesion may have been the infectious focus of tetanus. Treatment with penicillin G was very effective in the acute stage, and chronic administration of metronidazole prevented relapse of the disease. However in spite of injections of tetanus toxoid, symptoms of tetanus returned when the administration of metronidazole was discontinued because the infectious focus could not be completely removed. This is the first report of chronic relapsing tetanus associated with radiation-induced mandibular osteomyelitis, and demonstrates that tetanus can occur due to mandibular focus but the chronic administration of metronidazole can prevent relapse.
著者
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Suzuki Chieko
Department Of Gastroenterology And Hepatology Yamaguchi University School Of Medicine
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Shoji Mikio
Department Of Neurology Graduate School Of Medicine And Dentistry Okayama Univeristy
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Fujimuro Masahiro
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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TOMIYAMA Masahiko
Department of Neurological Science, Institute of Brain Science, Hirosaki University School of Medici
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KIMURA Tamaki
Department of Neurological Science, Institute of Brain Science, Hirosaki University School of Medici
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Matsubara Etsuro
Department Of Neurology Division Of Neuroscience Biophysical Science Okayama University Graduate Sch
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Watanabe Mitsunori
Department Of Neurology Gunma University School Of Medicine
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Kawarabayashi Takeshi
Department Of Neurology Division Of Neuroscience Biophysical Science Okayama University Graduate Sch
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Seino Yusuke
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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Jackson Mandy
Centre for Integrative Physiology, University of Edinburgh
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Wakasaya Yasuhito
Department of Neurology, Hirosaki University Graduate School of Medicine
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Yamamoto-Watanabe Yukiko
Department of Neurology, Hirosaki University Graduate School of Medicine
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Nakahata Naoko
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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Shirahama Ikumi
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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Takamura Ayumi
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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Shoji Mikio
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
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