Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
スポンサーリンク
概要
- 論文の詳細を見る
The Epstein-Barr virus (EBV)-encoded latency protein Epstein–Barr nuclear antigen 2 (EBNA2) is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. In a previous study, we demonstrated that EBNA2 interacts with signal transducer and activator of transcription 3 (STAT3), a signal transducer for an interleukin (IL)-6 family cytokine, and enhances its transcriptional activity. Here, we show that overexpression of a corepressor, silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), decreases the EBNA2-mediated enhanced STAT3 activation. Furthermore, small-interfering RNA-mediated reduction of endogenous SMRT expression augments the EBNA2-mediated enhanced STAT3 activation. Importantly, EBNA2 reduces interactions between STAT3 and SMRT. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3 by influencing the SMRT corepressor complex.
- Pharmaceutical Society of Japanの論文
著者
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MATSUDA Tadashi
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Shimoda K
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Shimoda Kazuya
九州大学 医学部病態情報学
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Matsuda Tadashi
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Shimoda Kazuya
九州大学 第1内科
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Sekine Yuichi
Department Of Nanomechanics Tohoku University
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FUJIMURO Masahiro
Department of Biochemistry Graduate School of Pharmaceutical Sciences, Hokkaido University
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IKEDA Osamu
Department of Diagnostic Radiology, Graduate School of Medicine, Kumamoto University
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Togi Sumihito
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Kamitani Shinya
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Muromoto Ryuta
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Nanbo Asuka
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Muromoto Ryuta
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ikeda Osamu
Department Of Diagnostic Radiology Graduate School Of Medical Sciences Kumamoto University
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Fujimuro Masahiro
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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Shimoda Kazuya
Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Sekine Yuichi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Sugio Y
Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn
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Ikeda Osamu
Department Of Chemistry Faculty Of Science Kanazawa University
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Ikeda Osamu
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Nanbo Asuka
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Fujimuro Masahiro
Department of Molecular Cell Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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Sekine Yuichi
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Ikeda Osamu
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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