Physical and functional interactions between STAT3 and ZIP kinase.

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概要

• 論文の詳細を見る

• Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor that can be activated by cytokines and growth factors. It plays important roles in cell growth, apoptosis and cell transformation, and is constitutively active in a variety of tumor cells. In this study, we provide evidence that zipper-interacting protein kinase (ZIPK) interacts physically with STAT3. ZIPK specifically interacted with STAT3, and did not bind to STAT1, STAT4, STAT5a, STAT5b or STAT6. ZIPK phosphorylated STAT3 on serine 727 (Ser727) and enhanced STAT3 transcriptional activity. Small interfering RNA-mediated reduction of ZIPK expression decreased leukemia inhibitory factor (LIF)- and IL-6-induced STAT3-dependent transcription. Furthermore, LIF- and IL-6-mediated STAT3 activation stimulated ZIPK activity. Taken together, our data suggest that ZIPK interacts with STAT3 within the nucleus to regulate the transcriptional activity of STAT3 via phosphorylation of Ser727.

• Oxford University Pressの論文
• 2005-12-01

著者

• SATO NORIKO

  Department of Pediatrics, Nihon University School of Medicine

• Matsuda Tadashi

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Shimoda Kazuya

  九州大学 第1内科

• AKIRA Shizuo

  Department of Host Defense, Research Institute for Microbial Diseases, Osaka University

• Sekine Yuichi

  Department Of Nanomechanics Tohoku University

• Kawai Taro

  Osaka Univ. Osaka Jpn

• Kawai Taro

  Department Of Host Defense Research Institute For Microbial Diseases Research Institute For Microbia

• Kawai Taro

  Department Of Host Defense Research Insutitute For Microbial Diseases Osaka University

• Sato Noriko

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Muromoto Ryuta

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• IMOTO Seiyu

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• SUGIYAMA Kenji

  Nippon Boehringer Ingelheim Co., Ltd., Kawanishi Pharma Research Institute

• Muromoto Ryuta

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• ISHIDA Masato

  Nippon Boehringer Ingelheim Co., Ltd, Kawanishi Pharma Research Institute

• Kawai Taro

  Department Of Host Defense Research Institute For Microbial Diseases Osaka University

• Imoto Seiyu

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Imoto Seiyu

  北海道大学 大学院薬学研究科

• Akira Shizuo

  Department Of Biochemistry Hyogo College Of Medicine

• Shimoda Kazuya

  Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University

• Kawai T

  Department Of Host Defense Research Insutitute For Microbial Diseases Osaka University

• Sekine Yuichi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Matsuda Tadashi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Sugiyama Kenji

  Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers

• Sugio Y

  Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn

• Sato Noriko

  Department Of Forest And Forest Products Sciences Fuculty Of Agriculture Kyushu Unviversity

• Sato Noriko

  Department Of Agricultural And Biological Chemistry Nihon University

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