Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice

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概要

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• Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7. Overexpression of STAP-2 in Raw264.7 cells markedly suppressed M-CSF-induced activation of extracellular signal regulated kinase and Akt. In addition, Raw264.7 overexpressing STAP-2 affected cell migration in wound-healing process. These results suggest that STAP-2 deficiency influences endogenous c-Fms/M-CSF receptor signaling. Here we show that loss of STAP-2 expression in knockout mouse macrophages results in marked enhancement of the c-Fms/M-CSF receptor signaling and wound-healing process. We therefore propose that STAP-2 acts as an endogenous regulator in normal macrophages functions.

• 社団法人日本薬学会の論文
• 2008-09-01

著者

• YOSHIMURA Akihiko

  Division of Molecular and Cellular Immunology and the Core Research for Evolutional Science and Tech

• Matsuda Tadashi

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Asano Y

  Department Of Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University

• Sekine Yuichi

  Department Of Nanomechanics Tohoku University

• IKEDA Osamu

  Department of Diagnostic Radiology, Graduate School of Medicine, Kumamoto University

• Muromoto Ryuta

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• OHBAYASHI Norihiko

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• Muromoto Ryuta

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Ikeda Osamu

  Department Of Diagnostic Radiology Graduate School Of Medical Sciences Kumamoto University

• Sekine Yuichi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Matsuda Tadashi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Ohbayashi Norihiko

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Sugio Y

  Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn

• Abe Yasunobu

  Department Of Microbiology And Immunology Keio University School Of Medicine

• Ikeda Osamu

  Department Of Chemistry Faculty Of Science Kanazawa University

• Ikeda Osamu

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Ikeda Osamu

  Department of Applied Chemistry, Faculty of Engineering, Osaka University

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