SOCS1/JAB Likely Mediates the Protective Effect of Cardiotrophin-1 Against Lipopolysaccharide-Induced Left Ventricular Dysfunction In Vivo
スポンサーリンク
概要
- 論文の詳細を見る
Background Suppressor of cytokine signaling 1 (SOCS1) is a negative regulator of cytokine signaling whose expression is induced in the rat heart by cardiotrophin-1 (CT-1). Sepsis-induced myocardial depression results from the expression of inducible nitric oxide synthase (iNOS) evoked by inflammatory cytokines. Methods and Results The effect of CT-1 on lipopolysaccharide (LPS)-induced cardiac dysfunction was examined in a rat model of sepsis. In the absence of CT-1, LPS (1mg/kg ip) elicited a reduction of systolic function and dilation of the ventricular cavity within 3-6h after administration. These physiological effects were accompanied by increased ventricular phosphorylation of signal transducers and activators of transcription (STAT) 1 and STAT3, activation of nuclear factor-κB and expression of iNOS mRNA. Notably, administration of CT-1 (20μg/kg iv) immediately prior to LPS significantly inhibited all of these LPS-induced changes. To determine whether SOCS1 expression in cardiomyocytes is sufficient to inhibit LPS- and cytokine-induced expression of iNOS mRNA, the effects of forced expression of SOCS1 in cultured neonatal cardiomyocytes were investigated using an adenovirus-mediated transfection system. Forced expression of SOCS1 significantly inhibited iNOS transcription induced by LPS, tumor necrosis factor-α or interferon-γ. Conclusions CT-1-mediated expression of SOCS1 in cardiomyocytes may be a useful target for preventing sepsis-induced myocardial depression.
- 社団法人日本循環器学会の論文
- 2005-10-20
著者
-
NAKAO Kazuwa
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
TANIMOTO Keiji
Department of Oral and Maxillofacial Radiology, School of Dentistry, Hiroshima University
-
Tanimoto Keiji
Departments Of Medicine And Clinical Science
-
Kuwahara Koichiro
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Nakagawa Yasuaki
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Nakanishi Michio
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Tanaka Norio
Saitama Medical University
-
Saito Yoshihiko
Department Of Clinical Cell Biology Chiba University Graduate School Of Medicine
-
YOSHIMURA Akihiko
Division of Molecular and Cellular Immunology and the Core Research for Evolutional Science and Tech
-
Takahashi Nobuki
Department Of Clinical Studies And Genetics Radiation Effects Research Foundation
-
Hamanaka Ichiro
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Takahashi Nobuki
Deparment Of Medicine Division Of Cardiovascular Medicine Kurume University School Of Medicine
-
Muratani H
Univ. Rykyus School Of Medicine Okinawa Jpn
-
Kawakami Rika
Department Of Cardiology National Cardiovascular Center
-
Kawakami Rika
Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
-
Nakao Kazuwa
奈良県立医科大学 内科学第一
-
Nakanishi Michio
Department Of Cardiology Kokura Memorial Hospital
-
Harada Masaki
Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
-
Nishitani Takahiro
The Second Department Of Internal Medicine Sapporo Medical College
-
NAKAMURA Kenjiro
Tenjin Sogo Clinic
-
Nakao Kazuwa
Department Of Endocrinology And Metabolism Kyoto University Graduate School Of Medicine
-
Adachi Yuichiro
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Tahara Nobuhiro
Department Of Internal Medicine Division Of Cardio-vascular Medicine And Cardiovascular Research Ins
-
Tahara Nobuhiro
Department Of The Third Internal Medicine Kurume University School Of Medicine
-
Nakamura Kazuyo
Department Of Preventive Medicine Faculty Of Medicine Saga University
-
Nakagawa Yasuaki
Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
-
Nakagawa Yasuaki
Department Of Electronics Tohoku Institute Of Technology
-
Nakanishi Michio
Department Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences Kyushu Universi
-
Nishimiya Takatoshi
The Second Department Of Internal Medicine Sapporo Medical College
-
Shirakami Gotaro
Anesthesia, Kyoto University Graduate School of Medicine
-
Fukuda Kazuhiko
Anesthesia, Kyoto University Graduate School of Medicine
-
Shirakami Gotaro
Anesthesia Kyoto University Graduate School Of Medicine
-
Shirakami Gotaro
Day Surgery Unit Kyoto University Hospital
-
Harada Masaki
Department Of Mechanical System Engineering Hiroshima University
-
Tanimoto Keiji
Department Of Biochemistry And Biophysics Research Institute For Radiation Biology And Medicine Hiro
-
Horio Masaru
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine (a8)
-
Saito Yoshihiko
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Yoshimura Akihiko
Division Of Molecular And Cellular Immunology Medical Institute Of Bioregulation Kyushu University
-
Takahashi Nobuyuki
Radiation Effects Research Foundation Hiroshima
-
Adachi Yuichiro
Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
-
Hamanaka Ichiro
Departments Of Medicine And Clinical Science
-
Tanimoto Keiji
Department Of Anesthesia Kyoto University Hospital
-
Shirakami Gotaro
Department Of Anesthesia And Pain Medicine Kagawa University Hospital
-
Nakao Kazuwa
Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine
-
Saito Yoshihiko
Department Of Cardiology Juntendo University School Of Medicine
-
Hamanaka Ichiro
Department of Cardiology, Rakuwakai Otowa Hospital
関連論文
- Effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease : subanalysis of the CASE-J Study
- Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes
- PE-165 An Important Role of p300 on Mitochondrial Gene Expression and Function and Tolerance to Ischemia in the Heart(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-007 Functional inhibition of p300 in the post-natal heart leads to mitochondrial dysfunction and cell death in mice(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Ci
- PE-441 Essential Role of p300 in Post-natal Cardiac Mitochondrial Gene Expression and Maintenance of Normal Cardiac Function(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The Specific Mineralocorticoid Receptor Blocker Eplerenone Attenuates Left Ventricular Remodeling in Mice Lacking the Gene Encoding Guanylyl Cyclase-A
- Role of diabetes and obesity in outcomes of the candesartan antihypertensive survival evaluation in Japan (CASE-J) trial
- 1 Which Risk Factor Has an Adverse Effect on Coronary Events in Japanese High-risk Hypertensive Patients? : a Subanalysis of CASE-J(Comprehensive Risk Management for Prevention of Coronary Artery Disease,Symposium 16 (SY-16) (H),The 73rd Annual Scientific
- IS040 Positive association between essential hypertension and Glu298Asp polymorphism in the endothelial nitric oxide synthase gene
- 0909 The Effects of the Angiotensin-Converting-Enzyme(ACE)Inhibitor Imidapril on Plasma Brain Natriuretic Peptide(BNP)in Patients With Acute Myocardial Infarction(AMI)
- 1 Which Risk Factor Has an Adverse Effect on Coronary Events in Japanese High-risk Hypertensive Patients? : a Subanalysis of CASE-J(Comprehensive Risk Management for Prevention of Coronary Artery Disease,Symposium 16 (SY-16) (H),The 73rd Annual Scientific
- Synergistic Augmentation of Neovascularizaiton by Transplantation of Human ES Cells-derived Endothelial Cells and Mural Cells-Approach Towards Hybrid Stem Cell Therapy(The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese
- Variations in the FTO gene are associated with severe obesity in the Japanese
- Prognostic value of myocardial perfusion SPECT images in combination with the maximal heart rate at exercise testing in Japanese patients with suspected ischemic heart disease: A sub-analysis of J-ACCESS
- DPE-007 Protein Kinase G-mediated Inhibition of TRPC6 Channel Activity Participates in Anti-hypertrophic Effect of Cardiac Natriuretic Peptides(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japan
- OE-172 A Novel NRSF-binding Partner Zfp90 Negatively Regulates the Repression Activity of NRSF, a Critical Regulator of Cardiac Fetal Gene Program(OE29,Molecular Biology Myocardium (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The
- Alteration of the p14^ gene and p53 status in human hepatocellular carcinomas
- OJ-253 Prognostic Value of the Double Product of Exercise Testing in Combination with Myocardial Perfusion Images : A Sub-Analysis of J-ACCESS(OJ43,Nuclear Cardiology (Coronary, Myocardium) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeti
- OJ-172 Prognostic Value of the Heart Rate of Exercise Testing in Combination with Myocardial Perfusion SPECT Images : A Sub-Analysis of J-ACCESS(Nuclear cardiology(02)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- 1 Leptin and Metabolic Syndrome(The metabolic syndrome and adipocytokines, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- A Case of Secretin-responsive Insulinoma with Low Serum C-peptide Levels
- Insulin-induced Lipohypertrophy : Report of a Case with Histopathology
- Clinical Manifestations due to a Point Mutation of the Mitochondrial tRNA^ Gene in Five Families with Diabetes Mellitus
- Lack of Mutations of Preproparathyroid Hormone Gene in Three Kindreds with Familial Isolated Hypoparathyroidism
- Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy
- OE-047 Regulator of G-Protein Signaling-4 Mediates Antihypertrophic Effect of Atrial Natriuretic Peptide in Cardiac Myocytes(Cardiac hypertrophy, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-177 Antihypertrophic Effect of Atrial Natriuretic Peptide is Mediated by Activation of Regulator of G-protein Signaling-4 in Cardiac Myocytes(Cardiac hypertrophy, basic/clinical-3 (M) PE30,Poster Session (English),The 70th Anniversary Annual Scientific
- OE-336 TAZ Functions as a Coactivator of GATA Family Proteins, and Notch Signaling Represses GATA Activity through TAZ(Development and differentiation(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- PJ-338 Identification and Characterization of New TBX5 Mutations from Holt-Oram Syndrome Patients in Japan(Congenital heart disease/Kawasaki's disease-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-440 TAZ and YAP Function as Critical Co-activators for TBX5 and Notch Signaling Represses TBX5 Activity(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Possible involvement of Atypical Protein Kinase C in Aldosterone-induced-Angiotensin-Converting-Enzyme Gene Expression in Cultured Neonatal Rat Cardiocytes
- Possible Involvement of Endothelin-1 in Cardioprotective Effects of Benidipine
- IS007 Interleukin-1b Induces Myocyte Hypertrophy and Production of B-type Natriuretic Peptide
- PJ-368 The Characteristic and Potential of Human ES and iPS-derived Vascular Cells(PJ062,Regeneration (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 4 Application of Natriuretic Peptides to Peripheral Artery Occlusive Diseases (PAOD)(New Progress in Clinical Application of Natriuretic Peptide Family,Roundtable Discussion 1 (RT1) (H),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
- Identification of Vascular Progenitor Cells from Human Embryonic Stem Cells and their Application to Vascular Regeneration Therapy(The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- cGMP-Dependent Protein Kinase Prevents Blood Pressure Elevation via Direct Phosphorylation and Inactivation of Small GTPase RhoA
- Identification of 'Vascular Progenitor Cells' from Primate Embryonic Stem Cells
- Contribution of Embryonic Stem (ES) Cell-Derived Vascular Progenitor Cells (VPC) to Neovascularization in Murine Hindlimb Ischemia Model
- Adrenomedullin Promotes Proliferation and Migration of Cultured Endothelial Cells
- Direct phosphorylation and inactivation of small GTPase RhoA by cGMP-dependent protein kinase and its implication in vascular remodeling
- Contribution of embryonic stem (ES) cell-derived vascular progenitor cells (VPC) to blood vessel formation during adult neoangiogenesis
- New Diagnostic Procedure for Primary Aldosteronism: Adrenal Venous Sampling under Adrenocorticotropic Hormone and Angiotensin II Receptor Blocker-Application to a Case of Bilateral Multiple Adrenal Microadenomas
- Effects of risedronate or alfacalcidol on bone mineral density, bone turnover, back pain, and fractures in Japanese men with primary osteoporosis : results of a two-year strict observational study
- A Case of Cortisol Producing Adrenal Adenoma without Phenotype of Cushing's Syndrome due to Impaired 11β-Hydroxysteroid Dehydrogenase 1 Activity
- Three-month changes in bone turnover markers and bone mineral density response to raloxifene in Japanese postmenopausal women with osteoporosis
- IS161 Rho-associated Kinase as a Critical Regulator of Proliferation and Migration of Vascular Smooth Muscle Cells Both in vitro and in vivo
- Lack of Association between T^→C Mutation in the 5'-Flanking Region of the Endothelial Nitric Oxide Synthase Gene and Essential Hypertension
- Pathogenesis of Graves' Disease : Molecular Analysis of Anti-Thyrotropin Receptor Antibodies
- ANALYSIS OF ANTI-TSH RECEPTOR ANTIBODY (TSHRAB) GENES AND PREPARATION OF RECOMBINANT ANTI-TSHRABS
- Predominant Effect of A-Type Natriuretic Peptide on Reduction of Oxidative Stress During the Treatment of Patients With Heart Failure
- PJ-220 Direct Effects of Aldosterone on Cardiomyocytes in the Presence of Normal and Elevated Extracellular Sodium(Hypertension, basic-3 (H) PJ37,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Difference between Fluvastatin and Simvastatin on the eNOS Gene Expression (Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Association of the Endothelial Nitric Oxide Synthase Gene Polymorphisms and Myocardial Contractility (Genetics/Genetically Engineered Models (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Expression and Role of Angiotensin II Type 2 Recepteor in the Kidney and Mesangial Cells of Spontaneously Hypertensive Rats
- ATRIAL NATRIURETIC POLYPEPTIDE INCREASES DURING ATRIAL PACING : Atrial Natriuretic Polypeptide (I) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 3 Efficient and Specific Expansion of Highly Cardiogenic Progenitors from Embryonic Stem Cells by Cyclosporin-A Treatment(Young Investigator's Award for International Students Finalists Lecture (YIA International),Special Program,The 72nd Annual Scientifi
- Association of CT Dinucleotide Repeat Polymorphism in the 5'-Flanking Region of the Guanylyl Cyclase (GC)-A Gene with Essential Hypertension in the Japanese
- Genetic Disruption of Angiotensin II Type 1a Receptor Improves Long-Term Survival of Mice With Chronic Severe Aortic Regurgitation
- Potential preventive effects of follistatin-related protein/TSC-36 on joint destruction and antagonistic modulation of its autoantibodies in rheumatoid arthritis
- Clinical Significance of 1-year Treatment with Raloxifene on Bone and Lipid Metabolism in Japanese Postmenopausal Women with Osteoporosis
- Activation of Proopiomelanocortin Gene Expression in Failing Human Heart
- Possible Cardioprotective Effect of Dehydroepiandrosterone Produced in the Human Heart
- Aldosterone Induces Angiotensin-Converting-Enzyme Gene Expression through Both Mineralcorticoid -and Glucocorticoid- Receptors in Cultured Neonatal Rat Cardiocytes
- Inhibitory Effect of Natriuretic Peptides on Aldosterone Synthase Gene Expression in Cultured Neonatal Rat Cardiocytes
- Plasma B-Type Natriuretic Peptide as a Prognostic Marker of Myocardial Infarction : Ten Years Follow-Up Study
- Increased risk of coronary spasm due to the combination of-786T to C mutation in eNOS gene and smoking
- Detection of CYP17 gene expression and the regulatory mechanisms in human vascular smooth muscle cells
- Proopiomelanocortin (POMC) gene expression in the human autopsy heart
- Significant Increase in Maternal Plasma Leptin Concentration in Induced Delivery : A Possible Contribution of Pro-inflammatory Cytokines to Placental Leptin Secretion
- Free-to-Total Leptin Ratio in Maternal Plasma is Constant Throughout Human Pregnancy
- Significant increase in maternal plasma leptin concentration during induced labor : A possible contribution of pro-inflammatory cytokines to placental leptin secretion(Session20 Peninatology5)
- Transgenic Approach toward Leptin Biology : The Clinical Implications of Leptin for the Treatment of Obesity-Associated Diabetes and Obesity-Related Hypertension
- Targered re-differentiation of proliferating vascular smooth muscle cells through cGMPcascade activation using adenoviral vector for C-type natriuretic peptide
- Incidence and Characteristics of Thyroid Dysfunction Following Interferon Therapy in Patients with Chronic Hepatitis C
- High-Dose Intravenous Steroid Pulse Therapy in Thyroid-Associated Ophthalmopathy
- Antigen-specific T_h1 cells as direct effectors of Propionibacterium acnes-primed lipopolysaccharide-induced hepatic injury
- Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases
- FRS-094 MRTF-A, a Rho-dependent Co-activaotr of SRF, Mediates Mechanical Stress-induced Hypertrophic Gene Reprogramming(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Session (English),The 73rd Annual Scientifi
- PE-305 The actin-binding Protein STARS is a Cytoskeletal Intermediary between MEF2 and SRF during Cardiac Remodeling(Cardiomyopathy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-210 TRPC6 Fulfills a Calcineurin Signaling Circuit During Pathological Cardiac Remodeling(Cardiac hypertrophy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Cellular Physiology of Rat Cardiac Myocytes in Cardiac Fibrosis : In Vitro Simulation Using the Cardiac Myocyte/Cardiac Non-Myocyte Co-Culture System
- Increased Bone Turnover in Patients with Hypercholesterolemia
- Efficacy of Combined Treatment with Raloxifene and Alfacalcidol on Bone Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis
- Association between Baseline Values of Bone Turnover Markers and Bone Mineral Density and Their Response to Raloxifene Treatment in Japanese Postmenopausal Women with Osteoporosis
- Mutation Analysis of Gsα, Adrenocorticotropin Receptor and p53 Genes in Japanese Patients with Adrenocortical Neoplasms: Including a Case of Gsα Mutation
- Expression of Prostaglandin E Receptor EP_4 Subtype in Rat Adrenal Zona Glomerulosa: Involvement in Aldosterone Release
- In-Vivo Electrophysiological Study in Dominant-Negative NRSF Transgenic Mice : Ventricular Arrhythmia Vulnerability and Sudden Cardiac Death
- High-fat diet reduces the stimulatory effects of a single bout of exercise on glucose transport and insulin sensitivity in rat skeletal muscle
- Aldosterone is Produced From the Ventricles in Patients With Essential Hypertension
- Adrenocorticotropin (ACTH) Production in the Hypertensive Human Heart
- Angiotensin II-Induced Ventricular Hypertrophy and Extracellular Signal-Regulated Kinase Activation Are Suppressed in Mice Overexpressing Brain Natriuretic Peptide in Circulation
- OJ-021 Blockade of T-type Calcium Channel Reduced the Arrythmogenicity in the Dominant Negative NRSF Transgenic Mice(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
- SOCS1/JAB Likely Mediates the Protective Effect of Cardiotrophin-1 Against Lipopolysaccharide-Induced Left Ventricular Dysfunction In Vivo
- PJ-622 Significance of a novel interaction between NRSF and classII HDAC involved in the induction of ANP gene expression by Endothelin-1(Cardiac Hypertrophy, Basic and Clinical 2 (M) : PJ104)(Poster Session (Japanese))
- OJ-481 Beneficial Effects of Brain Natriuretic Peptide Overexpression in Cardiac Remodeling after Myocardial Infarction in Mice(Old Myocardial Infarction/Remodeling 1 (IHD) : OJ59)(Oral Presentation (Japanese))
- Role of Renin-Anglotensin System in Cardiac Remodeling after Aortic Regurgitation in Mice
- ERK5 Plays a Critical Role in Cardiotrophin-1-Induced Hypertrophy of Neonatal Rat Ventricular Myocytes
- Evidence for Cardiac Myocyte Regeneration in Injured Myocardium by Bone Marrow Derived Cells