Predominant Effect of A-Type Natriuretic Peptide on Reduction of Oxidative Stress During the Treatment of Patients With Heart Failure
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概要
- 論文の詳細を見る
Background Oxidative stress plays an important role in the pathogenesis of heart failure and was investigated in the present study of the role of exogenous A-type natriuretic peptide (ANP) in the patients with heart failure and in cultured neonatal rat cardiomyocytes. Methods and Results The first protocol was to examine if an infusion of human ANP (carperitide) changed serum levels of TRX (thioredoxin) during the treatment of patients with heart failure compared with conventional therapy using furosemide. Protocol 2 investigated whether ANP had a direct antioxidant action on the failing heart by measuring TRX gene expression and reactive oxygen species (ROS) production in cultured neonatal rat cardiomyocytes. In Protocol 1, 8 patients were treated with only an intravenous bolus of furosemide and 11 patients with only an intravenous infusion of carperitide for 24 h. Serum TRX levels significantly de-creased at 4h (p<0.03) and at 24 h (p<0.05) in the carperitide group, whereas they decreased slightly but were not significantly different in the furosemide group. In Protocol 2, it was found that a low dose of exogenous ANP of 10^<-9>mol/L significantly suppressed TRX expression and ROS production in cardiomyocytes. Conclusion Carperitide infusion has a predominantly antioxidant action, in addition to improving the hemo-dynamics of patients with acute heart failure. Furthermore, carperitide infusion should have a direct antioxidant effect on the failing heart.
- 社団法人日本循環器学会の論文
- 2007-06-20
著者
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Suzuki Satoru
Department of Aging Medicine and Geriatrics, Shinshu University, Graduate School of Medicine
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Ogawa Hisao
Department of Cardiology, Kumamoto University
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Yoshimura Michihiro
Department of Caldiology Jikei University School of Medisine
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Yasujima Minoru
Kobe University
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Saito Yoshihiko
First Department of Medicine, Nara Medixal University
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ABE Keishi
Tohoku University
-
Yoshimura Michihiro
Division Of Cardiology Kumamoto University School Of Medicine
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NAKAO Kazuwa
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
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Nakayama Masafumi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Sugiyama Seigo
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Yamamuro Megumi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Abe Koji
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
-
Sugiyama Seigo
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Yasue Hirofumi
Division Of Cardiology Kumamoto University School Of Medicine
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Mizuno Yuji
Division Of Cardiology Kumamoto Aging Research Institute
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Yasujima Minoru
東北大学 医系研究内部障害学分野
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Yasujima M
Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine
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Abe Keishi
The Second Department Of Internal Medicine Tohoku University School Of Medicine And Henry Ford Hospi
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Nakao K
Kyoto University
-
Nakao Kazuwa
慶応義塾大学 内科学
-
Nakayama Masahumi
Department Of Cardiovasuclar Medicine Graduate School Of Medical Sciences Kumamoto University
-
Nakayama Masafumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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MIYAMOTO Shinzo
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Yokoi Hirokazu
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Abe Keishi
Division Of Hypertension And Diabetes Mellitus Sendai Social Insurance Hospital
-
Moriyama Yasushi
Kumamoto Central Hospital
-
Nakayama Masahumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
-
Sudo Y
Suzuki Clinic
-
Saito Yoshihiko
First Department Of Internal Medicine Nara Medical University
-
Nakao Kazuwa
奈良県立医科大学 内科学第一
-
Yasujima M
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Kato Norihiro
Department Of Gene Diagnostics And Therapeutics Research Institute International Medical Center Of J
-
Abe Keishi
Research Group On Evaluation Of The Effects Of Drug Treatment On Hypertension And Other Disease Cond
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Yasue Hirofumi
Division Of Cardilogy Kumamoto University School Of Medicine
-
Abe Koji
The Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Abe Keishi
Second Department Of Internal Medicine Tohoku University
-
Abe Keishi
Dept. Of Intern. Med. Tohoku Univ. Shool Of Medicine
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Miyamoto Shinzo
Division Of Cardiology Kumamoto Central Hospital
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Suzuki Satoru
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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NAKAMURA Kenjiro
Tenjin Sogo Clinic
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Nakao Kazuwa
Department Of Endocrinology And Metabolism Kyoto University Graduate School Of Medicine
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Yoshimura Michihiro
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Shono Makoto
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Morigami Yasuhiro
Department Of Atherosclerosis And Diabetes National Cardiovascular Center
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Nakamura Kazuyo
Department Of Preventive Medicine Faculty Of Medicine Saga University
-
Abe K
Tohoku University
-
Abe Keishi
The Second Department Of Internal Medicine
-
Sakamoto Makoto
Niigata Technical Junior College
-
Yamamuro Megumi
Graduate Sch Of Medical Sciences Kumamoto University
-
Yasujima Minoru
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Moriyama Yasushi
Division Of Cardiology Kumamoto Central Hospital
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Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
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Nakayama Masafumi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Abe Keishi
Department Of Medicine Tohoku University School Of Medicine
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Saitoh Yoshihiko
The Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
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Morikami Yasuhiro
Department Of Cardiology Japanese Red Cross Kumamoto Hospital
-
Sakamoto Mieko
Division Of Cardiology Kumamoto Central Hospital
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Abe Katsutoshi
Division Of Hypertension And Diabetes Mellitus Sendai Social Insurance Hospital
-
Yamamuro Megumi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Morikami Yasuhiro
Division Of Cardiology Kumamoto University
-
Yokoyama Hitoshi
Division Of Nephrology Kanazwa Medical University
-
Matsuzawa Yuji
Departments Of Internal Medicine And Molecular Science Osaka University Medical School
-
Nagatsuka Kazuyuki
Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
-
Mizuno Yuji
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Nakao Kazuwa
Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine
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Miyamoto Yoshihiro
Department Of Internal Medicine National Cardiovascular Center
-
Yoshida Masahiro
The Department Of Atherosclerosis And Diabetes National Cardiovascular Center
-
Abe Koji
Department Of Cardiovascular Medicine Kumamoto University
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Abe Koji
Department Of Applied Chemistry Graduate School Of Engineering Tohoku University
-
Nagatsuka Kazuyuki
Department Of Medicine And Clinical Sciences Graduate School Of Medicine Kyoto University
-
Nakayama Masafumi
Department of Cardiology, Tachikawa General Hospital, Japan
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Suzuki Satoru
Department of Aging and Geriatrics, Shinshu University, Graduate School of Medicine
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