Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients
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概要
- 論文の詳細を見る
Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe. As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring the levels of PFMs compared with the standard measurement of the urinary excretion of metanephrines (uMNs) whose reliability is well established to detect of pheochromocytoma. A total of 101 Japanese subjects clinically suspected of having pheochromocytoma in were included in this study. Subsequently, we prospectively measured the PFMs levels in all patients, compared with those of biochemical markers of the catecholamine secretion and metabolisms in the plasma and urine. All subjects with adrenal tumors underwent tumor excision. Data were available for 84 of the 101 patients, 47 of whom had histopathologically proven pheochromocytoma and 37 were finally diagnosed with non-pheochromocytoma. The results of comparisons in the accuracy of measurement for diagnosis of pheochromocytoma between PFMs and the urinary excretion of metanephrines (uMNs) were 0.980 VS 0.951 for AUC of receiver operatorating characteristic (ROC) curve, 0.957 VS 0.894 for sensitivity, and 0.973 VS 0.946 for specificity, respectively. Although the differences were small, the results of our study definitely demonstrated that measurement of PFMs was not inferior to standard urinary metanephrines (uMNs) measurement, which is established to be the most reliable biochemical method to detect pheochromocytoma. This study clearly shows measuring the PFMs levels to be a reliable and efficient method for diagnosing pheochromocytoma in Japanese patients, as demonstrated in previous reports.
- 一般社団法人 日本内分泌学会の論文
著者
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Shimano Hitoshi
Department Of Internal Medicine (endocrinology And Metabolism) Graduate School Of Comprehensive Huma
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Matsuda Tadashi
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Ikeda Yukihiro
Division Of Nephrology And Endocrinology Department Of Medicine Nihon University School Of Medicine
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Sakurai Akihiro
Department Of Aging Medicine And Geriatrics Shinshu University Graduate School Of Medicine
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KATO TAIYA
Department of Internal Medicine, Fujita Health University
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ISOBE KAZUMASA
Department of Clinical Pathology, University of Tsukuba
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Kikumori Toyone
Department Of Breast And Endocrine Surgery Nagoya University Hospital
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Okada Yosuke
The First Department Of Internal Medicine School Of Medicine University Of Occupational And Environm
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Maeda Yuji
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Midorikawa Sanae
Department Of Internal Medicine Iii Fukushima Medical University School Of Medicine
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Kawakami Yasushi
Department Of Biology Faculty Of Education Tottori University:(present Address)tottori West Technica
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Hataya Yuji
Department Of Endocrinology And Metabolism Shizuoka Hospital
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Tanaka Yuko
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Kamide Kei
Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical University School Of Medicine
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Yanase Toshihiko
Department of Endocrinology and Diabetes Medicine, Fukuoka University Hospital, Japan
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Adachi Masahiro
Department of Applied Chemistry, Faculty of Engineering, Tohoku University
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HARA Hisato
Department of Breast Thyroid Endocrine Surgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, Tsukuba University
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Yanase Toshihiko
Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan
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Ma Enbo
Biostatistics Office, Tsukuba Critical Path Research and Education Integrated Leading (CREIL) Center, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
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Imai Tsuneo
Division of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, Nagakute, Aichi 480-1195, Japan
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Takahashi Hideto
Biostatistics Office, Tsukuba Critical Path Research and Education Integrated Leading (CREIL) Center, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
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Yokoyama Chie
Division of Laboratory, University of Tsukuba Hospital, Tsukuba 305-8575, Japan
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Arai Yusuke
Division of Laboratory, University of Tsukuba Hospital, Tsukuba 305-8575, Japan
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Hashimoto Koichi
Tsukuba Critical Path Research and Education Integrated Leading Center (CREIL), Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
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Takekoshi Kazuhiro
Faculty of Medicine, Division of Sports Science, University of Tsukuba, Tsukuba 305-8575, Japan
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Maeda Yuji
Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan
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