Effect of Autologous Bone-Marrow Cell Transplantation on Ischemic Ulcer in Patients With Buerger's Disease
スポンサーリンク
概要
- 論文の詳細を見る
Background Thromboangiitis obliterans, also known as Buerger's disease, is characterized by peripheral occlusive changes in the arteries of the upper and lower limbs and treatment is often ineffective. Intramuscular transplantation of autologous bone marrow-mononuclear cells (BM-MNC) has been recently reported as improving the symptoms and clinical manifestations in patients with severely ischemic limbs, mostly caused by arteriosclerosis obliterans. The present study focused on the patients with Buerger's disease presenting with rest pain and/or skin ulcer uncontrolled by conventional treatments. Methods and Results Fourteen patients with Buerger's disease (Fontaine III: n=2, Fontaine IV: n=12) underwent transplantation of autologous BM-MNC into ischemic skeletal muscles of either the upper or lower limb. After 4 weeks, rest pain was significantly reduced. In 19 skin ulcers of 9 patients, 8 ulcers were healed and 8 were diminished in the size. These improvements were maintained for 24 weeks without complications. Conclusions In patients with Buerger's disease, intramuscular transplantation of autologous BM-MNC improved symptoms and clinical manifestations, especially skin ulcer.
- 社団法人日本循環器学会の論文
- 2007-07-20
著者
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AKASHI Hidetoshi
Department of Cardiovascular Surgery, Kurume University School of Medicine
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MUROHARA Toyoaki
Department of Cardiology, Nagoya University Graduate School of Medicine
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IMAIZUMI Tsutomu
Kurume University
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MUROHARA Toyoaki
Nagoya University
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Ikeda Hisao
Department of Cardiology, Kurume University Medical Center
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Ikeda Hisao
Division Of Cardiology Kurume University Medical Center
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Imaizumi Tsutomu
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
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SHINTANI Satoshi
Department of Cardiology, Nagoya University Graduate School of Medicine
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Imaizumi Tsutomu
Department Of Internal Medicine Division Of Cardiovascular Medicine And The Cardiovascular Research
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Matsuda Tadashi
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Katsuda Yousuke
Department of Cardiology, Nagoya University Graduate School of Medicine
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Arima Ken
Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University
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Ikeda Hisao
Kurume University Medical Center
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Imaizumi Tsutomu
Division Of Cardio-vascular Medicine Department Of Internal Medicine Kurume University School Of Med
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Arima Ken
Division Of Cardiovascular Medicine Department Of Medicine Kurume University School Of Medicine
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Arima Ken
Department Of Cardiology Surugadai Nihon University Hospital
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Ikeda Hisao
The Cardiovascular Research Institute And Department Of Internal Medicine Iii Kurume University Scho
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Saito Yutaka
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Murohara Toyoaki
Department Of Cardiology Nagoya University Graduate School Of Medicaine
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Sasaki Ken-ichiro
Division Of Cardio-vascular Medicine Department Of Internal Medicine Kurume University School Of Med
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Katsuda Yousuke
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Saitoh Yutaka
Division Of Cardiovascular Medicine Department Of Medicine Kurume University School Of Medicine
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SHIMADA Toshifumi
Department of Cerebrovascular Disease and Clinical Research Institute, National Kyushu Medical Cente
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IMAIZUMI Tutomu
VALISH Study Group
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Sasaki Ken-ichiro
Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of M
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Takeshita Yoshiaki
Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of M
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Okazaki Teiji
Department of Surgery, Kurume University School of Medicine
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Katsuki Yoshio
Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of M
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Shintani Satoshi
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Katuki Yoshio
Kurume University Of Medicine Internal Medicine Iii
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Akashi Hidetoshi
Department Of Cardiovascular Surgery Kurume University School Of Medicine
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Imaizumi Tsutomu
Deparment Of Medicine Division Of Cardiovascular Medicine Kurume University School Of Medicine
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Sasaki Ken-ichiro
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
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Takajyo Yoshinori
Division Of Cardiovascular Medicine Department Of Medicine Kurume University School Of Medicine
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Ikeda Hideo
Division Of Cardiology Kurume University Medical Center
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Ikeda Hisao
Department Of Internal Medicine Iii Kurume University School Of Medicine
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Ikeda Hisao
Department Of Cardiology Kurume University Medical Center
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Togawa Masaki
The Third Department Of Medicine Shiga University Of Medical Science
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Okazaki Teiji
Department Of Surgery Kurume University School Of Medicine
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Ikeda Hideo
Cardiovascular Research Institute Kurume Univ. School Of Med.
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Ikeda Hisao
The 3rd Dept. Of Int. Med. Kurume Univ.
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Moriyama Toshiki
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Shintani Satoshi
Departmdepartment Of Cardiology Nagoya University Graduate School Of Medicine
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Imaizumi Tsutomu
The Third Department Of Medicine Kurume University
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Terada Masahiko
Third Department Of Medicine Shiga University Of Medical Science
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Shimada Toshifumi
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
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Shimada Toshifumi
Department Of Cerebrovascular Disease And Clinical Research Institute National Kyushu Medical Center
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Ikeda Hisao
Dis. Kurume Univ. School Of Med. Kurume
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Imaizumi Tsutomu
Department Of Internal Medicine Division Of Cardiovascular Medicine And The Cardiovascular Research
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Imaizumi Tsutomu
Department Of Internal Medicine Division Of Cardiovascular Medicine And The Cardiovascular Research
-
Murohara Toyoaki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Imaizumi Tsutomu
Department Of Internal Medicine Division Of Cardiovascular Medicine And The Cardiovascular Research
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Matsuda Tadashi
The Department Of Urology Kansai Medical University
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Sasaki Kenichiro
Division Of Cardiovascular Medicine Department Of Internal Medicine Kurume University School Of Medi
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Saito Yutaka
Department Of Endoscopy National Cancer Center Hospital
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Sasaki Kenichiro
Division Of Cardio-vascular Medicine Department Of Internal Medicine Kurume University School Of Med
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Sasaki Kenichiro
Division Of Cardiovascular Medicine Department Of Internal Medicine Kurume University School Of Medi
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Izumi Toru
Department Of Cardiovascular Medicine Kitasato University School Of Medicine
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Akashi Hidetoshi
Department of Surgery, Kurume University School of Medicine
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Saito Yutaka
Department of Chemistry, Nagaoka University of Technology
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