KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
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概要
- 論文の詳細を見る
Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. Recently, we showed that KAP1 is a novel STAT-binding partner that regulates STAT3-mediated transactivation. KAP1 is a universal corepressor protein for the KRAB zinc finger protein superfamily of transcriptional repressors. In this study, we found KAP1-dependent repression of interferon (IFN) /STAT1-mediated signaling. We also demonstrated that endogenous KAP1 associates with endogenous STAT1 in vivo. Importantly, a small-interfering RNA-mediated reduction in KAP1 expression enhanced IFN-induced STAT1-dependent IRF-1 gene expression. These results indicate that KAP1 may act as an endogenous regulator of the IFN/STAT1 signaling pathway.
- Academic Pressの論文
- 2008-05-30
著者
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Shimoda K
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Shimoda Kazuya
九州大学 医学部病態情報学
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Shimoda Kazuya
九州大学 第1内科
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OHBAYASHI Norihiko
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Muromoto Ryuta
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Shimoda Kazuya
Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Sekine Yuichi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Matsuda Tadashi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ohbayashi Norihiko
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Sugiyama Kenji
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Sugio Y
Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn
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Ikeda Osamu
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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