BS69 negatively regulates the canonical NF-κB activation induced by Epstein-Barr virus-derived LMP1

スポンサーリンク

概要

• 論文の詳細を見る

• Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-κB signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor-associated factor 6. In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1-mediated NF-κB activation and up-regulates IL-6 mRNA expression and IκB degradation. Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD).

• Elsevierの論文
• 2009-05-19

著者

• Oritani K

  Osaka Univ. Osaka Jpn

• Oritani Kenji

  大阪大学 血液･腫瘍内科学

• Muromoto Ryuta

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Sekine Yuichi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Matsuda Tadashi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Sugio Y

  Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn

• Ikeda Osamu

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Mizushima Akihiro

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Nanbo Asuka

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

関連論文

• BS69 cooperates with TRAF3 in the regulation of Epstein–Barr virus-derived LMP1/CTAR1-induced NF-κB activation
• Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
• Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells
• Comparative Study on the Nuclear Hormone Receptor Activity of Various Phytochemicals and Their Metabolites by Reporter Gene Assays Using Chinese Hamster Ovary Cells(Molecular and Cell Biology)
• Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura With an IgG-Type Inhibitor to von Willebrand Factor-Cleaving Protease Activity
• Surface Modification of Alloy Tool Steel for Forging Dies by Cavitation Peening
• Physical and functional interactions between ZIP kinase and UbcH5
• An RNA biding protein, Y14 interacts with and modulates STAT3 activation
• Physical and functional interactions between STAT3 and KAP1
• BART is essential for nuclear retention of STAT3
• The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl
• STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation
• BS69 negatively regulates the canonical NF-κB activation induced by Epstein-Barr virus-derived LMP1
• The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation
• Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
• Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice
• STAP-2 Negatively Regulates both Canonical and Noncanonical NF-κB Activation Induced by Epstein-Barr Virus-Derived Latent Membrane Protein 1
• The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
• Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-β signaling
• KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
• LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation.
• DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118
• STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells.
• Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines
• HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A
• Epstein-Barr virus-derived EBNA2 regulates STAT3 activation
• The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals
• MLL Gene Rearrangement in t(9;11) Acute Myelogenous Leukemia With Minimal Myeloid Differentiation (FAB Subtype M0)
• Hapten-induced contact hypersensitivity is enhanced in Tyk2-deficient mice
• Physical and functional interactions between Daxx and TSG101.
• A Novel Mutation in the Juxtamembrane Intracellular Sequence of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Gene in a Patient with Severe Congenital Neutropenia Augments G-CSF Proliferation Activity but Not through the MAP Kinase Cascade
• Physical and functional interactions between STAP-2/BKS and STAT5.
• Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.
• Primary structure of alboaggregin-B purified from the venom of Trimeresurus albolabris.
• Interferon-ζ/Limitin : Novel Type I Interferon That Displays a Narrow Range of Biological Activity
• Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation
• Physical and functional interactions between STAT3 and ZIP kinase.
• Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4
• Improvement of the Fatigue Strength of Stainless Steel SUS316L by a Cavitating Jet with an Associated Water Jet in Water
• Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-β signaling.
• Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.
• Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor
• Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
• Regulation of transforming growth factor-β signaling by protein inhibitor of activated STAT, PIASy through Smad3.
• The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
• Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.
• Involvement of NF-kB in TGF-β-mediated suppression of IL-4 signaling.
• Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells
• Functional involvement of Daxx in gp130-medicated cell growth and survival in BaF3 cells
• Evaluation of Stress Anisotropy and Shearing Stress Using an Eddy Current Method with a Tangential-Rectangular Coil

もっと見る 閉じる

スポンサーリンク