Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines
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概要
- 論文の詳細を見る
Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site. Mutational analyses revealed that autophosphorylation of Thr265 was essential for its full catalytic activity toward an exogenous substrate as well as for cell death induction. Furthermore, leukemia inhibitory factor (LIF) stimulated Thr265 phosphorylation of ZIPK, thereby leading to phosphorylation and activation of signal transducer and activator of transcription (STAT3). Taken together, our findings demonstrate that ZIPK is positively regulated through Thr265 phosphorylation and that this phosphorylation is essential for its function.
- 2006-03-15
著者
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Shimoda Kazuya
九州大学 第1内科
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Kawai Taro
Osaka Univ. Osaka Jpn
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Kawai Taro
Department Of Host Defense Research Insutitute For Microbial Diseases Osaka University
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Sato Noriko
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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OHBAYASHI Norihiko
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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IMOTO Seiyu
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Muromoto Ryuta
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Imoto Seiyu
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Imoto Seiyu
北海道大学 大学院薬学研究科
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Shimoda Kazuya
Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Kawai T
Department Of Host Defense Research Insutitute For Microbial Diseases Osaka University
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Matsuda Tadashi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ohbayashi Norihiko
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Sugiyama Kenji
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Sugio Y
Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn
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