Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

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概要

• 論文の詳細を見る

• Interleukin-6 (IL-6) is a multifunctional cytokine playing roles in the immune system, hematopoiesis, and acute phase reactions. IL-6 also regulates the growth of various types of human malignant tumors. Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) inhibitor, geldanamycin (GA) in human hepatoma Hep3B cells. GA also suppressed the IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) in a human embryonic kidney carcinoma 293T cells. This inhibitory effect of GA on STAT3 activation was reversed by overexpression of Hsp90. Furthermore, Hsp90 directly bound to STAT3 via its N-terminal region, which interacted with GA. We provide evidence that the action of GA on IL-6 functions was due to the inhibition of direct physical interactions between STAT3 and Hsp90, which represents a novel role of Hsp90 in the IL-6 signaling pathways.

• Elsevierの論文
• 2003-01-24

著者

• Yamamoto Yu

  北海道大学 薬学研究院衛生化学

• Fuse Hideki

  富山医科薬科大学 放射線医学

• Fuse H

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Sato Noriko

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Matsuda Tadashi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Sugio Y

  Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn

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