Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.

スポンサーリンク

概要

• 論文の詳細を見る

• STAT3 mainly acts as a signal transducer of IL-6 family cytokines and transcriptionally activates specific target genes. STAT3 has also been demonstrated to mediate cellular transformation and is found in numerous cancers. Endocrine-disrupting chemicals (EDCs) are a diverse group of chemicals that bind to estrogen receptors (ERs), mimic estrogenic actions, and may have adverse effects on human health. In our previous study, we demonstrated that estrogens suppressed the STAT3-mediated transcription activity through ERs. In this study, we examined the effects of EDCs on STAT3-mediated signaling through ERs. Surprisingly, some of EDCs enhanced STAT3-mediated transcription activity through ERs. This finding strongly suggests that EDCs may play an important role in the endocrine functions by mimicking cytokine activity by stimulating STAT3 actions through ERs.

• Elsevierの論文
• 2004-03-12

著者

• Yamamoto Yu

  北海道大学 薬学研究院衛生化学

• IMOTO Seiyu

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• Imoto Seiyu

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Imoto Seiyu

  北海道大学 大学院薬学研究科

• Matsuda Tadashi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Sugio Y

  Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn

関連論文

• BS69 cooperates with TRAF3 in the regulation of Epstein–Barr virus-derived LMP1/CTAR1-induced NF-κB activation
• Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells
• Comparative Study on the Nuclear Hormone Receptor Activity of Various Phytochemicals and Their Metabolites by Reporter Gene Assays Using Chinese Hamster Ovary Cells(Molecular and Cell Biology)
• Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura With an IgG-Type Inhibitor to von Willebrand Factor-Cleaving Protease Activity
• Physical and functional interactions between ZIP kinase and UbcH5
• An RNA biding protein, Y14 interacts with and modulates STAT3 activation
• Physical and functional interactions between STAT3 and KAP1
• BART is essential for nuclear retention of STAT3
• The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl
• STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation
• BS69 negatively regulates the canonical NF-κB activation induced by Epstein-Barr virus-derived LMP1
• The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation
• Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
• Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice
• STAP-2 Negatively Regulates both Canonical and Noncanonical NF-κB Activation Induced by Epstein-Barr Virus-Derived Latent Membrane Protein 1
• The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
• Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-β signaling
• KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
• LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation.
• DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118
• STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells.
• Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines
• HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A
• Epstein-Barr virus-derived EBNA2 regulates STAT3 activation
• The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals
• MLL Gene Rearrangement in t(9;11) Acute Myelogenous Leukemia With Minimal Myeloid Differentiation (FAB Subtype M0)
• Hapten-induced contact hypersensitivity is enhanced in Tyk2-deficient mice
• Physical and functional interactions between Daxx and TSG101.
• A Novel Mutation in the Juxtamembrane Intracellular Sequence of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Gene in a Patient with Severe Congenital Neutropenia Augments G-CSF Proliferation Activity but Not through the MAP Kinase Cascade
• Physical and functional interactions between STAP-2/BKS and STAT5.
• Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.
• Primary structure of alboaggregin-B purified from the venom of Trimeresurus albolabris.
• Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation
• Physical and functional interactions between STAT3 and ZIP kinase.
• Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4
• Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-β signaling.
• Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.
• Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor
• Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
• Regulation of transforming growth factor-β signaling by protein inhibitor of activated STAT, PIASy through Smad3.
• The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
• The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.
• Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.
• Involvement of NF-kB in TGF-β-mediated suppression of IL-4 signaling.
• Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells
• Functional involvement of Daxx in gp130-medicated cell growth and survival in BaF3 cells

もっと見る 閉じる

スポンサーリンク