The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl
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概要
- 論文の詳細を見る
Signal transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2 (SH2)-like domains as well as a YXXQ motif in its C-terminal region. Our previous study in T cells demonstrated that STAP-2 influences FAK protein levels through recruitment of E3 ubiquitin ligase, Cbl, to FAK. In the present study, we found that Cbl directly controls the protein levels and activity of STAP-2. STAP-2 physically interacted with Cbl through its PH and SH2-like domains. Small-interfering RNA-mediated reduction of endogenous Cbl restored STAP-2 protein levels. In contrast, over-expression of Cbl induced STAP-2 degradation. Importantly, Cbl-mediated regulation of STAP-2 protein levels affected Brk/STAP-2-induced STAT3 activation. These results indicate that Cbl regulates STAP-2 protein levels and Brk/STAP-2-mediated STAT3 activation.
- Academic Pressの論文
- 2009-06-26
著者
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Asano Y
Department Of Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Oritani K
Osaka Univ. Osaka Jpn
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Oritani Kenji
大阪大学 血液･腫瘍内科学
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Muromoto Ryuta
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Sugio Y
Kyushu Univ. Fukuoka Jpn
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Sudo Yoshikazu
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Sekine Yuichi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Matsuda Tadashi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Sugio Y
Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn
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Abe Yasunobu
Department Of Microbiology And Immunology Keio University School Of Medicine
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Ikeda Osamu
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Nanbo Asuka
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Yamamoto Chikako
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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