The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
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概要
- 論文の詳細を見る
Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.
- Academic Pressの論文
- 2008-07-11
著者
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Shimoda K
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Shimoda Kazuya
九州大学 医学部病態情報学
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Shimoda Kazuya
九州大学 第1内科
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Honjoh Tsutomu
北海道大学 薬学研究院衛生化学
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OHBAYASHI Norihiko
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Muromoto Ryuta
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Shimoda Kazuya
Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Sekine Yuichi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Matsuda Tadashi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Ohbayashi Norihiko
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Sugiyama Kenji
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Sugio Y
Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn
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Ikeda Osamu
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
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