Physical and functional interactions between ZIP kinase and UbcH5
スポンサーリンク
概要
- 論文の詳細を見る
Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. In our previous study, we showed that leukemia inhibitory factor stimulated threonine-265 phosphorylation of ZIPK, thereby leading to phosphorylation and activation of signal transducer and activator of transcription 3. Here, we identified UbcH5c as a novel ZIPK-binding partner by yeast two-hybrid screening. Importantly, we found that UbcH5c induced ubiquitination of ZIPK. Small-interfering RNA-mediated reduction of endogenous UbcH5 expression decreased ZIPK ubiquitination. Furthermore, coexpression of UbcH5c with ZIPK influenced promyelocytic leukemia protein nuclear body (PML-NB) formation. These results suggest that UbcH5 regulates ZIPK accumulation in PML-NBs by interacting with ZIPK and stimulating its ubiquitination.
- 2008-08-08
著者
-
Shimoda K
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
-
Shimoda Kazuya
九州大学 医学部病態情報学
-
Shimoda Kazuya
九州大学 第1内科
-
Kawai Taro
Osaka Univ. Osaka Jpn
-
Kawai Taro
Department Of Host Defense Research Insutitute For Microbial Diseases Osaka University
-
Sato Noriko
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
-
OHBAYASHI Norihiko
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
Muromoto Ryuta
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
-
Shimoda Kazuya
Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
-
Kawai T
Department Of Host Defense Research Insutitute For Microbial Diseases Osaka University
-
Sekine Yuichi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
-
Matsuda Tadashi
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
-
Ohbayashi Norihiko
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
-
Sugiyama Kenji
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
-
Sugio Y
Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn
-
Ikeda Osamu
Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University
関連論文
- Rituximab in combination with CHOP chemotherapy for the treatment of diffuse large B cell lymphoma in Japan : a retrospective analysis of 1,057 cases from Kyushu Lymphoma Study Group
- 修正18ヶ月における極低出生体重児の発達の特徴-出生重による比較
- Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells
- Intensifying Daunorubicin in Induction for Patients with Core Binding Factor Leukemia
- 血漿脂質中アラキドン酸濃度の低値を示す肥満小児の特質に関する検討
- Reconstitution of HLA-A^*2402-Restricted Cytomegalovirus-Specific T-Cells following Stem Cell Transplantation
- Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients
- G-CSF does not Stimulate Leukemic Stem Cells in Vivo
- Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura With an IgG-Type Inhibitor to von Willebrand Factor-Cleaving Protease Activity
- Management of infection in patients with acute leukemia during chemotherapy in Japan : questionnaire analysis by the Japan Adult Leukemia Study Group
- Reduced-intensity unrelated donor bone marrow transplantation for hematologic malignancies
- Allogeneic Peripheral Blood Stem Cell Transplantation in 23 Adult Patients With Hematologic Malignancies: A Single-Center Experience
- Granulocyte Colony-Stimulating Factor and Lineage-Independent Modulation of VLA-4 Expression on Circulating CD34^+ Cells
- Replating potential of colony-forming units of granulocytes/macrophages (CFE-GM) expanded ex vivo by stem cell factor, interleukin (IL)-3, IL-6, granulocyte colony-stimulating factor, erythropoietin with or without thrombopoietin
- G-CSF-induced mobilization of peripheral blood stem cells for allografting: comparative study of daily single versus divided dose of G-CSF
- Predominant Infiltration of Monocytes in Chronic Graft-Versus-Host Disease
- Phase I/II study of humanized anti-CD33 antibody conjugated with calicheamicin, gemtuzumab ozogamicin, in relapsed or refractory acute myeloid leukemia : final results of Japanese multicenter cooperative study
- The effect of adding rituximab to CHOP-based therapy on clinical outcomes for Japanese patients with diffuse large B-cell lymphoma : a propensity score matching analysis
- Two Cases of Acute Promyelocytic Leukemia Complicated by Torsade de Pointes during Arsenic Trioxide Therapy
- Two Patients with All-trans Retinoic Acid-Resistant Acute Promyelocytic Leukemia Treated Successfully with Gemtuzumab Ozogamicin as a Single Agent
- Glanzmann Thrombasthenia with Acute Myeloid Leukemia Successfully Treated by Bone Marrow Transplantation
- Optimal scan time for evaluating pancreatic disease with positron emission tomography using F-18-fluorodeoxyglucose
- Avidin Chase Can Reduce Myelotoxicity Associated with Radioimmunotherapy of Experimental Liver Micrometastases in Mice
- Successful Engraftment of Allogeneic Peripheral Blood Stem Cell Transplant After Nonmyeloablative Preparative Regimen With Cytarabine and Cyclophosphamide: Report of 2 Cases
- Molecular characterization of total kininogen deficiency in Japanese patients
- Analysis of circulating hematopoietic progenitor cells after peripheral blood stem cell transplantation
- Risk of Neutropenic Fever and Early Infectious Complications after Autologous Peripheral Blood Stem Cell Transplantation for Malignant Diseases
- Successful Treatment of Progressive NK Cell Lymphoma with Allogeneic Peripheral Stem Cell Transplantation Followed by Early Cyclosporine Tapering and Donor Leukocyte Infusions
- Ocular Manifestation of Acute Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation
- Severe Bleeding Tendency Caused by Leukemic Infiltration and Destruction of Vascular Walls in Chronic Neutrophilic Leukemia
- Transient Factor VIII Inhibitor in a Hemophilia Patient After Staphylococcal Septic Shock Syndrome
- State Policy and Use of Forest Resources in Vietnam : An Explanation by Habermas's Theory of Communicative Action
- Successful treatment of cryoglobulinemic glomerulonephritis derived from Waldenstrom's macroglobulinemia by rituximab-CHOP and tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation
- Enhanced Calcium Absorption in the Small Intestine by a Phytate-removed Deamidated Soybean Globulin Preparation
- Phase I/II study of tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation for advanced multiple myeloma
- Use of micafungin versus fluconazole for antifungal prophylaxis in neutropenic patients receiving hematopoietic stem cell transplantation
- Calcineurin Inhibitor-Induced Irreversible Neuropathic Pain after Allogeneic Hematopoietic Stem Cell Transplantation
- Myositis as a Manifestation of Chronic Graft-Versus-Host Disease
- Allogeneic Peripheral Blood Stem Cell Transplantation for the Treatment of Refractory Follicular Lymphoma
- Treatment of Refractory Metastatic Choriocarcinoma with Tandem High-Dose Chemotherapy Supported by Peripheral Blood Stem Cell Transplantation : A Case Report
- Graft rejection and recovery of host-derived hematopoiesis after allogeneic bone marrow transplantation : relation to conditioning with high does etoposide and total body irradiation
- Physical and functional interactions between ZIP kinase and UbcH5
- Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage
- TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
- Metastasis to the Iris in Squamous Cell Lung Cancer
- High-Dose Etoposide Treatment for CNS Involvement in a Patient with Primary Non-Hodgkin's Lymphoma of the Breast
- Forest Shink Plan Using a Carbon Offset System
- Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease : tract-specific analysis
- An RNA biding protein, Y14 interacts with and modulates STAT3 activation
- Physical and functional interactions between STAT3 and KAP1
- BART is essential for nuclear retention of STAT3
- The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation
- Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
- STAP-2 Negatively Regulates both Canonical and Noncanonical NF-κB Activation Induced by Epstein-Barr Virus-Derived Latent Membrane Protein 1
- The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
- Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-β signaling
- KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
- LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation.
- DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118
- Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines
- HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A
- Epstein-Barr virus-derived EBNA2 regulates STAT3 activation
- The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals
- MLL Gene Rearrangement in t(9;11) Acute Myelogenous Leukemia With Minimal Myeloid Differentiation (FAB Subtype M0)
- Diffusion Tensor Imaging in Familial Spastic Paraplegia with Mental Impairment and Thin Corpus Callosum
- Pulmonary Thromboembolism : Evaluating the Indication and Effect of a Vena Caval Filter With Indium-111-Platelet Scintigraphy
- Usefulness of dual-head coincidence gamma camera with thick NaI crystals for nuclear oncology : Comparison with dedicated PET camera and conventional gamma camera with thin NaI crystals
- Radioimmunotherapy for Liver Micrometastases in Mice: Pharmacokinetics, Dose Estimation, and Long-term Effect
- Detection of Altered Adhesion Molecule Expression in Experimental Tumors by a Radiolabeled Monoclonal Antibody
- Anti-murine Antibody Response to Mouse Monoclonal Antibodies in Cancer Patients
- Vitamin D3 Treatment for Locally Advanced Thyroid Cancer : A Case Report
- Hapten-induced contact hypersensitivity is enhanced in Tyk2-deficient mice
- Physical and functional interactions between Daxx and TSG101.
- A Novel Mutation in the Juxtamembrane Intracellular Sequence of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Gene in a Patient with Severe Congenital Neutropenia Augments G-CSF Proliferation Activity but Not through the MAP Kinase Cascade
- In Vitro Study of Deoxymethylspergualin on Functions of Lymphocytes and Bone Marrow Cells From Healthy Volunteers
- Physical and functional interactions between STAP-2/BKS and STAT5.
- Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.
- Contribution of subtraction ictal SPECT coregistered to MRI to epilepsy surgery : a multicenter study
- Physical and functional interactions between STAT3 and ZIP kinase.
- Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4
- Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-β signaling.
- Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era
- Ikk-i, a novel Lipopolysaccharide-inducible kinase that is realted to lκB Kinases
- Diffuse cerebral hypomyelination with cerebellar atrophy and hypoplasia of the corpus callosum
- Pathological role of Toll-like receptor signaling in cerebral malaria
- Discrimination of bacterial lipoproteins by Toll-like receptor 6
- T_h transmigration anergy: a new concept of endothelial cell-T cell regulatory interaction
- Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity.
- Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.
- Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor
- Regulation of transforming growth factor-β signaling by protein inhibitor of activated STAT, PIASy through Smad3.
- Antiviral Signaling Through Pattern Recognition Receptors
- The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.
- Involvement of NF-kB in TGF-β-mediated suppression of IL-4 signaling.
- Systemic Vasculitis Associated with α1-antitrypsin Deficiency
- Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML) : Japan Adult Leukemia Study Group (JALSG)-AML206 study
- Analysis of bacteremia/fungemia and pneumonia accompanying acute myelogenous leukemia from 1987 to 2001 in the Japan Adult Leukemia Study Group
- Rapid progression and unusual premortal diagnosis of mucormycosis in patients with hematologic malignancies : analysis of eight patients
- Functional involvement of Daxx in gp130-medicated cell growth and survival in BaF3 cells
- Clinical Features and Outcomes of 35 Disseminated Intravascular Coagulation Cases Treated with Recombinant Human Soluble Thrombomodulin at a Single Institution