Clinical Features and Outcomes of 35 Disseminated Intravascular Coagulation Cases Treated with Recombinant Human Soluble Thrombomodulin at a Single Institution
スポンサーリンク
概要
- 論文の詳細を見る
Disseminated intravascular coagulation (DIC) is a clinical entity with high mortality and is characterized by multiple organ failure caused by activation of systemic intravascular coagulation. Although a standard treatment for DIC has not been established owing to the absence of randomized controlled trials, recent reports have indicated that recombinant human soluble thrombomodulin (rTM) is effective against DIC. To elucidate the clinical characteristics and outcomes of DIC, we retrospectively analyzed 35 DIC patients treated with rTM at our institution over a 2-year period (infectious disease: 21 cases; hematological disease: 14 cases). Diagnosis of DIC was based on the diagnostic criteria for DIC of the Japanese Ministry of Health and Welfare. In addition to the treatment of underlying diseases, we administered rTM for 6 consecutive days. Twenty-one (60.0%) of the DIC patients attained resolution of DIC at 7 days after administration (infectious disease: 61.9%; hematological disease: 57.1%). Furthermore, 7 of the remaining 14 DIC patients (who did not attain resolution at 7 days) attained resolution at an average of 12.1 days. Consequently, 28 (80.0%) of the 35 patients were alive with resolution of DIC after a 28-day observation period (infectious disease: 76.2%; hematological disease: 85.7%). Among them, for 7 (70%) of the 10 DIC patients with severe life-threatening bleeding symptoms without hemorrhagic shock, treatment with heparin was contraindicated; these patients were successfully treated with rTM without the progression of hemorrhage. In the majority of DIC patients, rTM administration may be an effective, safe, and feasible therapeutic modality producing a good outcome. [J Clin Exp Hematopathol 51(2) : 101-107, 2011]
- 日本リンパ網内系学会の論文
- 2011-11-01
著者
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坂本 弘明
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
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SUGIYAMA Haruo
Departments of Clinical Laboratory Science
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斉藤 広信
福島県立医科大学 医学部内科学第二講座
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Shimoda K
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Shimoda Kazuya
九州大学 医学部病態情報学
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Ishikawa Fumihiko
九州大学 医研究院病態修復内科学
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Shimoda Kazuya
九州大学 第1内科
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Himeji Daisuke
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Akashi Koichi
九州大学 医学研究院病態修復内科学
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Akashi K
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Akashi Koichi
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Akashi Koichi
Department Of Medicine & Biosystemic Science Kyushu University
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Yoshida Shuro
九州大学 医学研究院病態修復内科学
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Sakamaki Hisashi
琉球大学 医学部血液免疫検査学分野
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Sakamaki H
Hematology Division Tokyo Metropolitan Cancer And Infectious Diseases Center Komagome Hospital
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Sakamaki Hisashi
Department Of Hematology Tokyo Metropolitan Komagome Hospital
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Shinagawa K
Okayama Univ. Hospital Okayama Jpn
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Shinagawa Katsuji
岡山大学 第2内科
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Soda Hisashi
Department Of Hematology Tokyo Metropolitan Komagome Hospital
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Suzuki Hisamitsu
国立療養所中部病院長寿医療研究センター
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Kawano Noriaki
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Kawano Noriaki
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Shimoda Kazuya
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Sunami K
Department Of Hematology National Hospital Organization Okayama Medical Center
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Sunami Kazutaka
Division Of Hematology Department Of Internal Medicine National Hospital Organization Okayama Medica
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Shinagawa Katsushi
The Second Department Of Internal Medicine
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Shinagawa Katsuji
Division Of Hematology/oncology Okayama University Medical School
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Saito H
Nagoya National Hospital Nagoya Jpn
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Yoshida Shuro
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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UEZONO Shigehiro
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital
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Kawano Noriaki
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Sakamaki Hisashi
Tokyo Metropolitan Komagome Hospital Tokyo Jpn
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Yamashita Kiyoshi
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Ueda Akira
Department Of Applied Mathematics And Physics Faculty Of Engineering Kyoto University
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Saito Hidehiko
Nagoya Central Hospital Nagoya Jpn
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Ikeda Naoko
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Ikeda Naoko
Department Of Cardiology Fukuoka Wajiro Hospital
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Shimoda Kazuya
Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Nakase Koichi
Department Of Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Kikuchi Ikuo
Department Of Internal Medicine Miyazaki Prefectural Hospital
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Suzuki Hideyoshi
Division Of Hematology Tokyo Metropolitan Komagome Hospital
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Himeji Daisuke
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Ishikawa Fumihiko
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Uezono Shigehiro
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Yamashita Kiyoshi
Department Of Hematology And Oncology Graduate School Of Medicine University Of Tokyo
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Shimoda Kazuya
Department Of Cardiology Jichi Medical School
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Sugiyama Katsuki
Division Of Hematology And Oncology Department Of Internal Medicine The Jikei University School Of M
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Ochiai Hidenobu
Department Of Neurosurgery Miyazaki Medical College
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Ono Nobuyuki
Department Of Electronics And Control Engineering Nagano National College Of Technology
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Ueda Akira
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Ishikawa Fumihiko
Research Unit For Human Disease Models Riken Research Center For Allergy And Immunology
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Hayashi Shin
Department Of Molecular Cytogenetics Medical Research Institute And School Of Biomedical Science Tok
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NAGAHIRO Yuri
Department of Psychiatry, Shiranui Hospital
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KAWANO Sayaka
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital
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KAWANO Fumiko
Faculty of Letters, University of Keio
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Nagahiro Yuri
Department Of Psychiatry Shiranui Hospital
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Kawano Sayaka
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Kawano Fumiko
Faculty Of Letters University Of Keio
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Ochiai Hidenobu
Department Of Neurosurgery Miyazaki Prefectural Miyazaki Hospital
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Ono Nobuyuki
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Hayashi S
Department Of Molecular Cytogenetics Medical Research Institute And School Of Biomedical Science Tokyo Medical And Dental University
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Kawano Noriaki
Department Of Hematology Harasanshin Hospital
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山本 豪
Department of Internal Medicine 2, Fukushima Medical University School of Medicine
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KIKUCHI Ikuo
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital
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Akashi Koichi
Department of Hematology/Oncology, Kyushu University Hospital, Japan
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AKASHI Koichi
Department of Hematology and Oncology, Graduate School of Medical Sciences, Kyushu University
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