Unrelated Bone Marrow Transplantation Induced Long-Term Remission in a Patient with Life-Threatening Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis
スポンサーリンク
概要
- 論文の詳細を見る
We present a case of life-threatening Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) with severe hepatitis that was successfully treated by allogeneic stem cell transplantation from an unrelated donor. A 26-year-old woman was admitted to hospital with a high fever and liver dysfunction. Laboratory tests, including bone marrow aspiration, revealed severe HLH that occurred after EBV infection. High-dose methylprednisolone and etoposide therapy did not control the disease. We could control the HLH, but the EBV viremia continued following the CHOPE (cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide) chemotherapy regimen. Therefore, the patient underwent allogeneic bone marrow transplantation from an HLA-matched, unrelated donor. The patient has remained in good condition without disease recurrence for 2 years after bone marrow transplantation. Although there is no consensus regarding allogeneic stem cell transplantation for EBV-HLH, it is the treatment of choice for aggressive EBV-HLH when the patient is refractory to intensive chemotherapy. [J Clin Exp Hematopathol 51(1) : 57-61, 2011]
- 日本リンパ網内系学会の論文
- 2011-05-01
著者
-
Kunitomi Akane
Department of Hematology, Meitetsu Hospital
-
Iida Hiroatsu
Department of Hematology, Meitetsu Hospital
-
坂本 弘明
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
-
SUGIYAMA Haruo
Departments of Clinical Laboratory Science
-
斉藤 広信
福島県立医科大学 医学部内科学第二講座
-
Akashi Koichi
九州大学 医学研究院病態修復内科学
-
Akashi K
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
-
Akashi Koichi
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
-
Sakamaki Hisashi
琉球大学 医学部血液免疫検査学分野
-
Sakamaki H
Hematology Division Tokyo Metropolitan Cancer And Infectious Diseases Center Komagome Hospital
-
Sakamaki Hisashi
Department Of Hematology Tokyo Metropolitan Komagome Hospital
-
Hiraoka Sakamaki
Department Of Hematology Tokyo Metropolitan Komagome Hospital
-
Sao Hiroshi
Department Of Hematology Hamamatsu Medical Center
-
Kunitomi Akane
Department Of Hematology Meitetsu Hospital
-
Iida Hiroatsu
Department Of Hematology Meitetsu Hospital
-
Saito H
Nagoya Central Hospital
-
Soda Hisashi
Department Of Hematology Tokyo Metropolitan Komagome Hospital
-
Soda Hisashi
Department Of Internal Medicine Isahaya Insurance General Hospital
-
Suzuki Hisamitsu
国立療養所中部病院長寿医療研究センター
-
Naitoh Kazuyuki
Departments Of Internal Medicine Komaki City Hospital
-
Saito H
Nagoya National Hospital
-
Saito H
Nagoya National Hospital Nagoya Jpn
-
Sakamaki Hisashi
Tokyo Metropolitan Komagome Hospital Tokyo Jpn
-
Sakamaki H
Tokyo Metropolitan Komagome Hospital Tokyo Jpn
-
Ito Yoshinori
Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research
-
Saito Hidehiko
Nagoya Central Hospital Nagoya Jpn
-
Nakase Koichi
Department Of Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
-
Suzuki Hideyoshi
Division Of Hematology Tokyo Metropolitan Komagome Hospital
-
Shishido Hideo
Third Department Of Internal Medicine Dokkyo University School Of Medicine
-
Sakamaki Hisashi
Department Of Internal Medicine Tokyo Metropolitan Komagome Hospital
-
Kunitomi Akane
Department Of Hematology And Oncology Ja Aichi Konan Kosei Hospital
-
Kimura Hiroshi
Department Of Virology Nagoya University Graduate School Of Medicine
-
NODA Nobuhiko
Department of Hematology, Komaki City Hospital
-
Noda Nobuhiko
Department Of Hematology Komaki City Hospital
-
Ito Yoshinori
Department Of Biomedical Food Research National Institute Of Infectious Diseasea(former National Ins
-
Kimura Hiroshi
Department Of Anatomy Shiga University Of Medical Science
-
Naitoh Kazuyuki
Department Of Hematology Komaki City Hospital
-
Hayashi Shin
Department Of Molecular Cytogenetics Medical Research Institute And School Of Biomedical Science Tok
-
Ito Yoshinori
Department Of Biochemistry Nagoya City University Medical School
-
Ishida Hiroshi
Kyowa Hakko Kirin Fuji Research Park
-
Kimura Hiroshi
Department Of Anatomy Ii Shiga University Of Medical Science
-
Hayashi S
Department Of Molecular Cytogenetics Medical Research Institute And School Of Biomedical Science Tokyo Medical And Dental University
-
山本 豪
Department of Internal Medicine 2, Fukushima Medical University School of Medicine
関連論文
- A SIMPLE AND SELECTIVE HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF PARAQUAT AND DIQUAT IN HUMAN URINE
- Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia : results of the JALSG AML97 study
- Pulmonary Nocardiosis Developed in a Hematopoietic Stem Cell Transplant Recipient with Bronchiolitis Obliterans
- The Authors Reply: Sleep Complaints in Hospitalized Italian Patients with Hematological Malignancies
- Insomnia and Depression during Protective Isolation in Patients with Hematological Disorders
- 急性肝炎様に発症し短期間で典型的な組織像を呈した自己免疫性肝炎の1例
- EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS
- Usefulness of Endoscopic Ultrasonographic Analysis of Variceal Hemodynamics for the Treatment of Esophageal Varices
- Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients
- A CASE OF RAPIDLY EXPANDING AND INCREASING FOCAL NODULAR HYPERPLASIA
- 胃静脈瘤硬化療法における超音波内視鏡の有用性についての検討 - 静脈瘤径からみた硬化剤の選択 -
- 原発性胆汁性肝硬変にACTH単独欠損症を合併した1例
- BREAKTHROUGH OF IMMUNE SELF-TOLERANCE TO CALRETICULIN INDUCED BY CpG-OLIGODEOXYNUCLEOTIDES AS ADJUVANT
- Activated protein C resistance in the Japanese population due to homozygosity for the factor V R2 haplotype
- Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission
- Molecular monitoring of BAALC expression in patients with CD34-positive acute leukemia
- Successful treatment of relapsed T-cell non-Hodgkin's lymphoma with allogeneic peripheral blood stem cell transplantation with double conditioning
- Successful treatment of relapsed T-cell non-Hodgkin's lymphoma with allogeneic peripheral blood stem cell transplantation with double conditioning
- Monitoring Minimal Residual Disease in Leukemia Using Real-time Quantitative Polymerase Chain Reaction for Wilms Tumor Gene (WT1)
- Expression of the Wilms' Tumor Gene WT1 in Solid Tumors and Its Involvement in Tumor Cell Growth
- Expression of the Wilms' Tumor Gene WT1 in Solid Tumors and Its Involvement in Tumor Cell Growth
- 混合性結合組織病に合併した肝細胞癌の1例
- Basedow 病に合併した自己免疫性肝炎の1例
- 経鼻持続陽圧気道圧法を併用し胸膜癒着術が奏効した難治性肝性胸水の2例
- 自己免疫性肝炎の経過中に抗セントロメア抗体が陽性化し, Raynaud 現象が出現した1例
- Role of CpG ODN in Concanavalin A-Induced Hepatitis in Mice
- MPR画像が経皮的エタノール局注療法に有用であった肝細胞癌の1例
- C型慢性肝炎患者におけるIFN・リバビリン併用療法時のTh1/Th2バランス比および血中ケモカインに関する検討
- Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size : a report by the Nagasaki CML Study Group
- Peripheral blood stem cell versus bone marrow transplantation from HLA-identical sibling donors in patients with leukemia : a propensity score-based comparison from the Japan Society for Hematopoietic Stem Cell Transplantation registry
- Reconstitution of HLA-A^*2402-Restricted Cytomegalovirus-Specific T-Cells following Stem Cell Transplantation
- Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients
- Oral valganciclovir as preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
- Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9
- Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient
- Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia
- Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan
- Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis
- Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission : a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group
- Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol
- 肝機能異常を伴った多発性骨髄腫の1例
- Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide
- High frequencies of less differentiated and more proliferative WT1-specific CD8^+ T Cells in bone marrow in tumor-bearing patients : An important role of bone marrow as a secondary lymphoid organ
- Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8^+ T cells in patients with myeloid malignancies
- Use of foscarnet for cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation from a related donor
- Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma
- Granulocyte colony-stimulating factor-combined marrow-ablative chemotherapy and autologous blood cell transplantation for the treatment of patients with acute myelogenous leukemia in first remission
- びまん性腹膜中皮腫6年半生存例
- Safe switching from dasatinib to nilotinib after a 1-month off-drug period for persistent pleural effusion in patients with chronic myelogenous leukemia in chronic phase
- Successful treatment of refractory advanced nasal NK/T cell lymphoma with unrelated cord blood stem cell transplantation incorporating focal irradiation
- Second unrelated cord blood transplantation using a reduced-intensity conditioning regimen combined with gemtuzumab ozogamicin in patients with relapsed acute myelogenous leukemia
- Rituximab for the treatment of corticosteroid-refractory chronic graft-versus-host disease
- Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion
- Successful treatment using tacrolimus ointment for cutaneous graft-versus-host disease
- Low-Dose Cyclosporin A with Short-Term Methotrexate for Graft-versus-Host Disease Prophylaxis in Allogeneic Bone Marrow Transplantation from Human Leukocyte Antigen-Identical Siblings : A Prospective Phase II Study in Japanese Patients
- Twenty Years' Experience in Allogeneic Hematopoietic Stem Cell Transplantation for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in the Nagoya Blood and Marrow Transplantation Group
- POSSIBLE ASSOCIATION OF CYTOTOXIC T LYMPHOCYTE ANTIGEN-4 GENETIC POLYMORPHISM WITH LIVER DAMAGE OF PRIMARY BILIARY CIRRHOSIS IN JAPAN
- CLINICOLABORATORY CHARACTERISTICS OF JAPANESE PATIENTS WITH PRIMARY BILIARY CIRRHOSIS-AUTOIMMUNE HEPATITIS OVERLAP
- EXPRESSION OF HUMAN GLUCOCORTICOID RECEPTOR BETA OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH SEVERE AUTOIMMUNE HEPATITIS
- UFTが奏効した骨転移を伴う肝細胞癌の1例
- Overexpression of the Wilms' tumor gene WT1 in primary astrocytic tumors
- Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer
- Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas
- Wilms Tumor Gene WT1 Peptide-Based Immunotherapy Induced a Minimal Response in a Patient with Advanced Therapy-Resistant Multiple Myeloma
- WT1_, a Ninemer Peptide Derived from Wilms' Tumor Gene Product, Is a Candidate Peptide for the Vaccination of HLA-A^*0201-Positive Patients with Hematopoietic Malignancies
- WT1 Peptide-Based Immunotherapy for Patients with Lung Cancer : Report of Two Cases
- Wilms Tumor Gene Peptide-Based Immunotherapy for Patients with Overt Leulemia from Myelodysplastic Syndrome (MDS) or MDS with Myelofibrosis
- The lck Promoter-Driven Expression of the Wilms Tumor Gene WT1 Blocks Intrathymic Differentiation of T-Lineage Cells
- Wilms' tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion in vitro
- Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma
- Successful Treatment of Diffuse Large B-cell Lymphoma Following Waldenstrom's Macroglobulinemia with CHOP Chemotherapy Followed by Combination Therapy of CHOP with Rituximab
- OX40 Signaling Renders Adult T-Cell Leukemia Cells Resistant to Fas-Induced Apoptosis
- Lymphoid development from hematopoietic stem cells
- WT1 (Wilms' Tumor 1) Peptide Immunotherapy for Renal Cell Carcinoma
- 原発性胆汁性肝硬変に全身性エリテマトーデスを合併した2例
- Wegener's granulomatosis detected initially by integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography
- Overexpression of the Wilms′tumor gene WT1 in head and neck squamous cell carcinoma
- 胆嚢隆起性病変の超音波内視鏡的検討
- Efficient Induction of Pptide - Specific Cytotoxic T Lymphocytes by LPS - Activated Spleen Cells
- Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia : A report from the BINGO study
- Identification of a WT1 protein-derived peptide, WT1_, : as a HLA-A^*0206-restricted, WT1-specific CTL epitope
- A WT1 protein-derived, naturally processed 16-mer peptide, WT1_, is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4^+ T cells
- Unrelated Bone Marrow Transplantation Induced Long-Term Remission in a Patient with Life-Threatening Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis
- 原発性胆汁性肝硬変に全身性エリテマトーデスを合併した2例
- 多発性筋炎を合併した自己免疫性肝炎の1例
- 肝機能異常を伴った多発性骨髄腫の1例
- Analysis of bacteremia/fungemia and pneumonia accompanying acute myelogenous leukemia from 1987 to 2001 in the Japan Adult Leukemia Study Group
- Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation
- Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia : a retrospective safety analysis
- Osteonecrosis of the humeral head
- Clinical Features and Outcomes of 35 Disseminated Intravascular Coagulation Cases Treated with Recombinant Human Soluble Thrombomodulin at a Single Institution
- Advances in therapies for acute promyelocytic leukemia
- Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis
- Successful treatment by donor lymphocyte infusion of adult T-cell leukemia/lymphoma relapse following allogeneic hematopoietic stem cell transplantation
- USEFULNESS OF INTRAOPERATIVE ESOPHAGOGASTRODUODENOSCOPY IN A PATIENT WITH LUPUS ENTERITIS
- Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
- Encephalomyelitis Mimicking Multiple Sclerosis Associated with Chronic Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation
- Fatal candidemia caused by azole-resistant Candida tropicalis in patients with hematological malignancies
- 原発性胆汁性肝硬変症における食道・胃静脈瘤の検討
- Nilotinib exacerbates diabetes mellitus by decreasing secretion of endogenous insulin